FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319300711> ?p ?o ?g. }

• W4319300711 abstract "Abstract Understanding the claustrum’s functions has recently progressed thanks to new anatomical and behavioral studies in rodents, which suggest that it plays an important role in attention, salience detection, slow-wave generation, and neocortical network synchronization. Nevertheless, knowledge about the origin and development of the claustrum, especially in primates, is still limited. Here, we show that neurons of rhesus macaque claustrum primordium are generated between embryonic day E48 and E55 and express some neocortical molecular markers, such as NR4A2, SATB2, and SOX5. However, in the early stages, it lacks TBR1 expression, which separates it from other surrounding telencephalic structures. We also found that two waves of neurogenesis (E48 and E55) in the claustrum, corresponding to the birthdates of layers 6 and 5 of the insular cortex, establish a “core” and “shell” cytoarchitecture, which is potentially a basis for differential circuit formation and could influence information processing underlying higher cognitive functions of the claustrum. In addition, parvalbumin-positive interneurons are the dominant interneuron type in the claustrum in fetal macaque, and their maturation is independent of that in the overlaying neocortex. Finally, our study reveals that the claustrum is likely not a continuance of subplate neurons of the insular cortex, but an independent pallial region, suggesting its potentially unique role in cognitive control. Significance Statement The claustrum is believed to have a role in many high cognitive functions. However, the origin and development of this mysterious structure remain unknown, and the understanding of its relationship with the neocortex is ambiguous. Here we examined neuron origin and development of claustrum in rhesus macaque during the prenatal and postnatal periods. We found that the claustrum is formed as an independent telencephalic area as early as E55, and it seems not related to the subplate of the insula, although it shares some molecular characteristics with the neocortex. The claustrum excitatory neurons are generated sequentially around E48 and E55 and build a “core and shell” structure that may be a basic computing neuronal circuit unit underlying higher cognitive functions." @default.
• W4319300711 created "2023-02-07" @default.
• W4319300711 creator A5014068004 @default.
• W4319300711 creator A5038455977 @default.
• W4319300711 creator A5089868470 @default.
• W4319300711 date "2023-02-06" @default.
• W4319300711 modified "2023-09-27" @default.
• W4319300711 title "Origin and Development of the Claustrum in Rhesus Macaque" @default.
• W4319300711 cites W1593237336 @default.
• W4319300711 cites W1594918742 @default.
• W4319300711 cites W1863427091 @default.
• W4319300711 cites W1970719523 @default.
• W4319300711 cites W1979952856 @default.
• W4319300711 cites W1985705162 @default.
• W4319300711 cites W1999238485 @default.
• W4319300711 cites W2000259625 @default.
• W4319300711 cites W2001851145 @default.
• W4319300711 cites W2010819208 @default.
• W4319300711 cites W2059038971 @default.
• W4319300711 cites W2065166944 @default.
• W4319300711 cites W2066414103 @default.
• W4319300711 cites W2080521851 @default.
• W4319300711 cites W2090469211 @default.
• W4319300711 cites W2121148760 @default.
• W4319300711 cites W2139123731 @default.
• W4319300711 cites W2162423225 @default.
• W4319300711 cites W2169863709 @default.
• W4319300711 cites W2187119052 @default.
• W4319300711 cites W2295472897 @default.
• W4319300711 cites W2320413387 @default.
• W4319300711 cites W2403547050 @default.
• W4319300711 cites W2494245850 @default.
• W4319300711 cites W2781989649 @default.
• W4319300711 cites W2886911869 @default.
• W4319300711 cites W2891418156 @default.
• W4319300711 cites W2911513099 @default.
• W4319300711 cites W2924187963 @default.
• W4319300711 cites W2972557997 @default.
• W4319300711 cites W3006676863 @default.
• W4319300711 cites W3014834246 @default.
• W4319300711 cites W3023510342 @default.
• W4319300711 cites W3035425961 @default.
• W4319300711 cites W4200151083 @default.
• W4319300711 cites W4206222539 @default.
• W4319300711 cites W4295902039 @default.
• W4319300711 doi "https://doi.org/10.1101/2023.02.06.527286" @default.
• W4319300711 hasPublicationYear "2023" @default.
• W4319300711 type Work @default.
• W4319300711 citedByCount "0" @default.
• W4319300711 crossrefType "posted-content" @default.
• W4319300711 hasAuthorship W4319300711A5014068004 @default.
• W4319300711 hasAuthorship W4319300711A5038455977 @default.
• W4319300711 hasAuthorship W4319300711A5089868470 @default.
• W4319300711 hasBestOaLocation W43193007111 @default.
• W4319300711 hasConcept C163895629 @default.
• W4319300711 hasConcept C169760540 @default.
• W4319300711 hasConcept C17077164 @default.
• W4319300711 hasConcept C203014093 @default.
• W4319300711 hasConcept C204232928 @default.
• W4319300711 hasConcept C26265296 @default.
• W4319300711 hasConcept C2777222312 @default.
• W4319300711 hasConcept C2777348757 @default.
• W4319300711 hasConcept C2778950215 @default.
• W4319300711 hasConcept C2779296341 @default.
• W4319300711 hasConcept C2779409897 @default.
• W4319300711 hasConcept C2779920484 @default.
• W4319300711 hasConcept C2780723820 @default.
• W4319300711 hasConcept C4746552 @default.
• W4319300711 hasConcept C86803240 @default.
• W4319300711 hasConceptScore W4319300711C163895629 @default.
• W4319300711 hasConceptScore W4319300711C169760540 @default.
• W4319300711 hasConceptScore W4319300711C17077164 @default.
• W4319300711 hasConceptScore W4319300711C203014093 @default.
• W4319300711 hasConceptScore W4319300711C204232928 @default.
• W4319300711 hasConceptScore W4319300711C26265296 @default.
• W4319300711 hasConceptScore W4319300711C2777222312 @default.
• W4319300711 hasConceptScore W4319300711C2777348757 @default.
• W4319300711 hasConceptScore W4319300711C2778950215 @default.
• W4319300711 hasConceptScore W4319300711C2779296341 @default.
• W4319300711 hasConceptScore W4319300711C2779409897 @default.
• W4319300711 hasConceptScore W4319300711C2779920484 @default.
• W4319300711 hasConceptScore W4319300711C2780723820 @default.
• W4319300711 hasConceptScore W4319300711C4746552 @default.
• W4319300711 hasConceptScore W4319300711C86803240 @default.
• W4319300711 hasLocation W43193007111 @default.
• W4319300711 hasOpenAccess W4319300711 @default.
• W4319300711 hasPrimaryLocation W43193007111 @default.
• W4319300711 hasRelatedWork W1526114854 @default.
• W4319300711 hasRelatedWork W2019528658 @default.
• W4319300711 hasRelatedWork W2034577104 @default.
• W4319300711 hasRelatedWork W2070990906 @default.
• W4319300711 hasRelatedWork W2111787229 @default.
• W4319300711 hasRelatedWork W2123073409 @default.
• W4319300711 hasRelatedWork W2612398037 @default.
• W4319300711 hasRelatedWork W4311853812 @default.
• W4319300711 hasRelatedWork W4319300711 @default.
• W4319300711 hasRelatedWork W87533215 @default.
• W4319300711 isParatext "false" @default.
• W4319300711 isRetracted "false" @default.
• W4319300711 workType "article" @default.