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- W4319302523 endingPage "109775" @default.
- W4319302523 startingPage "109775" @default.
- W4319302523 abstract "The liver is a well-known metabolic organ that can be susceptible to external stimuli to affect its normal physiological function. Worldwide, the morbidity and mortality of liver diseases are skyrocketing every year, causing human health crises. Recently, new approaches such as biotechnology have been introduced to achieve optimal treatment and prognostic management of liver diseases. microRNAs (miRNAs), a kind of small non-coding RNA molecule, have the advantages of biodiversity, wide distribution and numerous members. Among these miRNAs, miR-155 is an important regulator of inflammation, immunity and tumorigenesis. In this review, the PubMed and Web of Science databases were searched from 2009 to 2022. After inclusion and exclusion, 64 articles were selected for a systematic review to comprehensively summarize the mechanisms of miR-155 regulating inflammation, immunity and tumorigenesis in liver diseases and liver cancer, covering in vitro, in vivo and clinical studies. Existing preclinical studies and clinical trials have listed that the up-regulation and down-regulation of miR-155 are significant in alcoholic liver injury, viral hepatitis, autoimmune hepatitis, infectious liver injury, liver transplantation and liver cancer. The immune and inflammation effects of miR-155 are manifested by regulating macrophage polarization, NK cell killing, Th17 cell and Th1/Th2 cell differentiation. Additionally, miR-155 is also committed to participating in the cell cycle, invasion and metastasis, immune escape and other processes to promote and intensify the development of liver cancer. In conclusion, miR-155 is not only a biomarker for the diagnosis and prognosis of liver diseases, but also plays a therapeutic role via regulating immunity, inflammation and tumorigenesis." @default.
- W4319302523 created "2023-02-07" @default.
- W4319302523 creator A5008111914 @default.
- W4319302523 creator A5013540955 @default.
- W4319302523 creator A5017076715 @default.
- W4319302523 creator A5020504197 @default.
- W4319302523 creator A5028810524 @default.
- W4319302523 creator A5037677450 @default.
- W4319302523 creator A5087288951 @default.
- W4319302523 date "2023-03-01" @default.
- W4319302523 modified "2023-09-30" @default.
- W4319302523 title "The role of miR-155 on liver diseases by modulating immunity, inflammation and tumorigenesis" @default.
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