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- W4319303627 abstract "Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidence that the inflammasome sensor, NLRP1, is a key mediator of senescence induced by irradiation both in vitro and in vivo. The NLRP1 inflammasome promotes senescence by regulating the expression of p16, p21, p53, and SASP in Gasdermin D (GSDMD)-dependent manner as these responses are reduced in conditions of NLRP1 insufficiency or GSDMD inhibition. Mechanistically, the NLRP1 inflammasome is activated downstream of the cytosolic DNA sensor cGMP-AMP (cGAMP) synthase (cGAS) in response to genomic damage. These findings provide a rationale for inhibiting the NLRP1 inflammasome-GSDMD axis to treat senescence-driven disorders." @default.
- W4319303627 created "2023-02-07" @default.
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- W4319303627 date "2023-02-06" @default.
- W4319303627 modified "2023-10-01" @default.
- W4319303627 title "NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype" @default.
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- W4319303627 doi "https://doi.org/10.1101/2023.02.06.527254" @default.
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