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• W4319308344 abstract "<b>Background: </b> Previous human clinical trials of insulin-like growth factor type I (IGF-1) in amyotrophic lateral sclerosis (ALS) have been inconsistent. This phase III, randomized, double-blind, placebo-controlled study was undertaken to address whether IGF-1 benefited patients with ALS. <b>Methods: </b> A total of 330 patients from 20 medical centers were randomized to receive 0.05 mg/kg body weight of human recombinant IGF-1 given subcutaneously twice daily or placebo for 2 years. The primary outcome measure was change in their manual muscle testing score. Secondary outcome measures included tracheostomy-free survival and rate of change in the revised ALS functional rating scale. Intention to treat analysis was used. <b>Results: </b> There was no difference between treatment groups in the primary or secondary outcome measures after the 2-year treatment period. <b>Conclusions: </b> Insulin-like growth factor type I does not provide benefit for patients with amyotrophic lateral sclerosis. <b>GLOSSARY: </b><b>ALS</b> = amyotrophic lateral sclerosis; <b>ALSFRS-r</b> = revised ALS functional rating scale; <b>AUC</b> = area under the curve; <b>DVT</b> = deep venous thromboses; <b>IGF-1</b> = insulin-like growth factor type I; <b>MMT</b> = manual muscle testing; <b>PE</b> = pulmonary embolisms." @default.
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• W4319308344 date "2008-11-24" @default.
• W4319308344 modified "2023-10-17" @default.
• W4319308344 title "Subcutaneous IGF-1 is not beneficial in 2-year ALS trial" @default.
• W4319308344 doi "https://doi.org/10.1212/01.wnl.0000335970.78664.36" @default.
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