FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319310326> ?p ?o ?g. }

• W4319310326 endingPage "111396" @default.
• W4319310326 startingPage "111396" @default.
• W4319310326 abstract "Glucocorticoids (GCs) are an essential mediator hormone that can regulate animal growth, behavior, the phenotype of offspring, and so on, while GCs in poultry are predominantly corticosterones. The biological activity of GCs is mainly regulated by the intracellular metabolic enzymes, including 11β-hydroxysteroid dehydrogenases 1 (11β-HSD1), 11β-hydroxysteroid dehydrogenases 2 (11β-HSD2), and 20-hydroxysteroid dehydrogenase (20-HSD). To investigate the embryonic mechanisms of phenotypic differences between breeds, we compared the expression of corticosterone metabolic enzyme genes in the yolk-sac membrane and chorioallantoic membrane (CAM). We described the tissue distribution and ontogenic patterns of corticosterone metabolic enzymes during embryonic incubation between Tibetan and broiler chickens. Forty fertilized eggs from Tibetan and broiler chickens were incubated under hypoxic and normoxic conditions, respectively. Real-time fluorescence quantitative PCR was used to examine the expression of 11β-HSD1/2, and 20-HSD mRNA in embryonic tissues. The results showed that the expression levels of yolk-sac membrane mRNA of 11β-HSD2 and 20-HSD in Tibetan chickens on E14 (embryonic day of 14) were significantly lower than those of broiler chickens (P < 0.05), and these genes expression of CAM in Tibetan chickens were higher than those of broiler chickens (P < 0.05). In addition, the three genes in the yolk-sac membrane and CAM were followed by a down-regulation on E18 (embryonic day of 18). The 11β-HSD1 and 11β-HSD2 genes followed a similar tissue-specific pattern: the expression level was more abundantly in the liver, kidney, and intestine, with relatively lower abundance in the hypothalamus and muscle, and the expression level of 20-HSD genes in all tissues tested was higher. In the liver, 20-HSD of both Tibetan and broiler chickens showed different ontogeny development patterns, and hepatic mRNA expression of 20-HSD in broiler chickens was significantly higher than that of Tibetan chickens of the same age from E14 to E18 (P < 0.05). This study preliminarily revealed the expression levels of cortisol metabolic genes in different tissues during the development process of Tibetan and broiler chicken embryos. It provided essential information for in-depth research of the internal mechanism of maternal GCs programming on offspring." @default.
• W4319310326 created "2023-02-08" @default.
• W4319310326 creator A5013927865 @default.
• W4319310326 creator A5021197072 @default.
• W4319310326 creator A5037781679 @default.
• W4319310326 creator A5043855146 @default.
• W4319310326 creator A5049553371 @default.
• W4319310326 creator A5069696119 @default.
• W4319310326 date "2023-06-01" @default.
• W4319310326 modified "2023-09-26" @default.
• W4319310326 title "Comparative study on the gene expression of corticosterone metabolic enzymes in embryonic tissues between Tibetan and broiler chickens" @default.
• W4319310326 cites W1484458782 @default.
• W4319310326 cites W1968410874 @default.
• W4319310326 cites W1980736290 @default.
• W4319310326 cites W2021826013 @default.
• W4319310326 cites W2033476803 @default.
• W4319310326 cites W2040246725 @default.
• W4319310326 cites W2055622775 @default.
• W4319310326 cites W2058191370 @default.
• W4319310326 cites W2065320333 @default.
• W4319310326 cites W2078698555 @default.
• W4319310326 cites W2079329450 @default.
• W4319310326 cites W2094502922 @default.
• W4319310326 cites W2103385164 @default.
• W4319310326 cites W2107277218 @default.
• W4319310326 cites W2110715786 @default.
• W4319310326 cites W2122322098 @default.
• W4319310326 cites W2135412294 @default.
• W4319310326 cites W2171461865 @default.
• W4319310326 cites W2409416249 @default.
• W4319310326 cites W2794879643 @default.
• W4319310326 cites W2912130635 @default.
• W4319310326 cites W2981601926 @default.
• W4319310326 doi "https://doi.org/10.1016/j.cbpa.2023.111396" @default.
• W4319310326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36754112" @default.
• W4319310326 hasPublicationYear "2023" @default.
• W4319310326 type Work @default.
• W4319310326 citedByCount "0" @default.
• W4319310326 crossrefType "journal-article" @default.
• W4319310326 hasAuthorship W4319310326A5013927865 @default.
• W4319310326 hasAuthorship W4319310326A5021197072 @default.
• W4319310326 hasAuthorship W4319310326A5037781679 @default.
• W4319310326 hasAuthorship W4319310326A5043855146 @default.
• W4319310326 hasAuthorship W4319310326A5049553371 @default.
• W4319310326 hasAuthorship W4319310326A5069696119 @default.
• W4319310326 hasConcept C104317684 @default.
• W4319310326 hasConcept C112672928 @default.
• W4319310326 hasConcept C126322002 @default.
• W4319310326 hasConcept C134018914 @default.
• W4319310326 hasConcept C140793950 @default.
• W4319310326 hasConcept C145103041 @default.
• W4319310326 hasConcept C150194340 @default.
• W4319310326 hasConcept C16685009 @default.
• W4319310326 hasConcept C18903297 @default.
• W4319310326 hasConcept C196843134 @default.
• W4319310326 hasConcept C2777043721 @default.
• W4319310326 hasConcept C2779234561 @default.
• W4319310326 hasConcept C2780289900 @default.
• W4319310326 hasConcept C2780352252 @default.
• W4319310326 hasConcept C2781321622 @default.
• W4319310326 hasConcept C54355233 @default.
• W4319310326 hasConcept C55493867 @default.
• W4319310326 hasConcept C71315377 @default.
• W4319310326 hasConcept C71924100 @default.
• W4319310326 hasConcept C86803240 @default.
• W4319310326 hasConcept C87073359 @default.
• W4319310326 hasConcept C95444343 @default.
• W4319310326 hasConcept C97230052 @default.
• W4319310326 hasConceptScore W4319310326C104317684 @default.
• W4319310326 hasConceptScore W4319310326C112672928 @default.
• W4319310326 hasConceptScore W4319310326C126322002 @default.
• W4319310326 hasConceptScore W4319310326C134018914 @default.
• W4319310326 hasConceptScore W4319310326C140793950 @default.
• W4319310326 hasConceptScore W4319310326C145103041 @default.
• W4319310326 hasConceptScore W4319310326C150194340 @default.
• W4319310326 hasConceptScore W4319310326C16685009 @default.
• W4319310326 hasConceptScore W4319310326C18903297 @default.
• W4319310326 hasConceptScore W4319310326C196843134 @default.
• W4319310326 hasConceptScore W4319310326C2777043721 @default.
• W4319310326 hasConceptScore W4319310326C2779234561 @default.
• W4319310326 hasConceptScore W4319310326C2780289900 @default.
• W4319310326 hasConceptScore W4319310326C2780352252 @default.
• W4319310326 hasConceptScore W4319310326C2781321622 @default.
• W4319310326 hasConceptScore W4319310326C54355233 @default.
• W4319310326 hasConceptScore W4319310326C55493867 @default.
• W4319310326 hasConceptScore W4319310326C71315377 @default.
• W4319310326 hasConceptScore W4319310326C71924100 @default.
• W4319310326 hasConceptScore W4319310326C86803240 @default.
• W4319310326 hasConceptScore W4319310326C87073359 @default.
• W4319310326 hasConceptScore W4319310326C95444343 @default.
• W4319310326 hasConceptScore W4319310326C97230052 @default.
• W4319310326 hasFunder F4320330122 @default.
• W4319310326 hasFunder F4320333335 @default.
• W4319310326 hasFunder F4320335787 @default.
• W4319310326 hasLocation W43193103261 @default.
• W4319310326 hasLocation W43193103262 @default.
• W4319310326 hasOpenAccess W4319310326 @default.
• W4319310326 hasPrimaryLocation W43193103261 @default.

• next