Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319311036> ?p ?o ?g. }
- W4319311036 endingPage "111701" @default.
- W4319311036 startingPage "111701" @default.
- W4319311036 abstract "High blood glucose levels, excessive production of reactive oxygen species (ROS), unbalanced inflammatory responses and impaired angiogenesis render chronic wounds more likely to be colonized by bacteria which can form biofilms, leading to recurrent infections and prolonging disunion. The pH-responsive fibers of poly (vinyl alcohol) (PVA)/poly (acrylic acid) (PAA) -epigallocatechin gallate (EGCG) have been constructed. The fibers were able to swell (pH > 7.4) /shrink (pH < 6.5) reversibly with changes in wound pH, controlling the rate of drug release and thus dynamically modulating the complex inflammatory environment of the wound. At the phase of bacterial infection (pH = 7–9), the polycarboxylic acid groups in the network ionized, and the dynamic hydrogen bond between EGCG and PVA and PAA was broke, triggered an increased release of EGCG (87.4 %). Thereafter, the EGCG cleared excess ROS (greater than80.0 %) from the wound and showed significant antibacterial activity against S. aureus (98 %) and Pseudomonas aeruginosa (96.7 %), inhibited biofilm formation (74 %). At the proliferative phase, the wound switched to acidic (pH ∼ 6.5). Fibers swelled less and tended to shrink. The release of EGCG was slowed down (45.8 %) to promote macrophage polarization and remodel the wound microenvironment." @default.
- W4319311036 created "2023-02-08" @default.
- W4319311036 creator A5001241898 @default.
- W4319311036 creator A5013481556 @default.
- W4319311036 creator A5023704552 @default.
- W4319311036 creator A5028701730 @default.
- W4319311036 creator A5029484872 @default.
- W4319311036 creator A5039205614 @default.
- W4319311036 creator A5063287623 @default.
- W4319311036 date "2023-03-01" @default.
- W4319311036 modified "2023-09-27" @default.
- W4319311036 title "Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing" @default.
- W4319311036 cites W1958070586 @default.
- W4319311036 cites W1976398449 @default.
- W4319311036 cites W1983671562 @default.
- W4319311036 cites W1985308473 @default.
- W4319311036 cites W1987806044 @default.
- W4319311036 cites W2018673349 @default.
- W4319311036 cites W2029738070 @default.
- W4319311036 cites W2050301775 @default.
- W4319311036 cites W2050656614 @default.
- W4319311036 cites W2055348159 @default.
- W4319311036 cites W2071117491 @default.
- W4319311036 cites W2087668378 @default.
- W4319311036 cites W2136672281 @default.
- W4319311036 cites W2144874527 @default.
- W4319311036 cites W2160982143 @default.
- W4319311036 cites W2165578318 @default.
- W4319311036 cites W2166698592 @default.
- W4319311036 cites W2169553434 @default.
- W4319311036 cites W2200832510 @default.
- W4319311036 cites W2416572171 @default.
- W4319311036 cites W2567221680 @default.
- W4319311036 cites W2579302807 @default.
- W4319311036 cites W2600121819 @default.
- W4319311036 cites W2780849109 @default.
- W4319311036 cites W2787901343 @default.
- W4319311036 cites W2799712382 @default.
- W4319311036 cites W2800380311 @default.
- W4319311036 cites W2886408624 @default.
- W4319311036 cites W2886533633 @default.
- W4319311036 cites W2896658628 @default.
- W4319311036 cites W2900290122 @default.
- W4319311036 cites W2903119425 @default.
- W4319311036 cites W2907596505 @default.
- W4319311036 cites W2914078155 @default.
- W4319311036 cites W2950937623 @default.
- W4319311036 cites W2952558159 @default.
- W4319311036 cites W2971637962 @default.
- W4319311036 cites W2994608318 @default.
- W4319311036 cites W2994813412 @default.
- W4319311036 cites W2995523985 @default.
- W4319311036 cites W2998830565 @default.
- W4319311036 cites W3000034372 @default.
- W4319311036 cites W3002390066 @default.
- W4319311036 cites W3010302794 @default.
- W4319311036 cites W3033894152 @default.
- W4319311036 cites W3042355947 @default.
- W4319311036 cites W3043481359 @default.
- W4319311036 cites W3044153360 @default.
- W4319311036 cites W3047317117 @default.
- W4319311036 cites W3126655892 @default.
- W4319311036 cites W3128690557 @default.
- W4319311036 cites W3156009602 @default.
- W4319311036 cites W3158131307 @default.
- W4319311036 cites W3163579061 @default.
- W4319311036 cites W3164079031 @default.
- W4319311036 cites W3164869969 @default.
- W4319311036 cites W3164949448 @default.
- W4319311036 cites W3167598216 @default.
- W4319311036 cites W3173117944 @default.
- W4319311036 cites W3175585286 @default.
- W4319311036 cites W3191204195 @default.
- W4319311036 cites W3196545263 @default.
- W4319311036 cites W3197470808 @default.
- W4319311036 cites W3197974564 @default.
- W4319311036 cites W3200948703 @default.
- W4319311036 cites W4200455774 @default.
- W4319311036 cites W4200552544 @default.
- W4319311036 cites W4206487251 @default.
- W4319311036 cites W4210613915 @default.
- W4319311036 cites W4214496645 @default.
- W4319311036 cites W4214523546 @default.
- W4319311036 cites W4220788135 @default.
- W4319311036 cites W4224916346 @default.
- W4319311036 cites W4229080567 @default.
- W4319311036 cites W4284968438 @default.
- W4319311036 cites W611557535 @default.
- W4319311036 doi "https://doi.org/10.1016/j.matdes.2023.111701" @default.
- W4319311036 hasPublicationYear "2023" @default.
- W4319311036 type Work @default.
- W4319311036 citedByCount "3" @default.
- W4319311036 countsByYear W43193110362023 @default.
- W4319311036 crossrefType "journal-article" @default.
- W4319311036 hasAuthorship W4319311036A5001241898 @default.
- W4319311036 hasAuthorship W4319311036A5013481556 @default.
- W4319311036 hasAuthorship W4319311036A5023704552 @default.
- W4319311036 hasAuthorship W4319311036A5028701730 @default.