Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319315709> ?p ?o ?g. }
- W4319315709 endingPage "108425" @default.
- W4319315709 startingPage "108425" @default.
- W4319315709 abstract "Orientia tsutsugamushi, the causative agent of scrub typhus has been found resistant to various classes of antibiotics such as penicillins, gentamycin and cephalosporins. Review of current literature suggests that the prevalence of scrub typhus has increased globally. Therefore, the current study has aimed at exploring the genome of O. tsutsugamushi to identify potential drug target proteins that can be used for developing novel antibiotics against the pathogen. Subtractive proteomics approach has revealed FIS as a potential drug target protein involved in two component system (TCS), a signaling pathway crucial for bacteria to survive and adjust in changing environmental conditions. Molecular docking studies have revealed compound-356 (CHEMBRIDGE-10040641-3710.356) as a potential inhibitor in both chains A and B of the FIS protein. Simulation results suggest that the docked complex has remained stable and compact throughout the 200 ns run. Significant conformational changes including the hinge motion was observed in the DNA binding domain. Furthermore, the presence of salt bridge between GLU910 and ARG417, rearrangement of interaction residues and displacement of ATP in the central AAA + domain upon binding to the inhibitor were also observed playing a role in stabilizing the protein structure." @default.
- W4319315709 created "2023-02-08" @default.
- W4319315709 creator A5024210822 @default.
- W4319315709 creator A5036929679 @default.
- W4319315709 creator A5075143843 @default.
- W4319315709 date "2023-05-01" @default.
- W4319315709 modified "2023-09-29" @default.
- W4319315709 title "Role of hinge motion and ATP dynamics in factors for inversion stimulation FIS protein deduced while targeting drug resistant Orientia tsutsugamushi" @default.
- W4319315709 cites W1803102843 @default.
- W4319315709 cites W1986191025 @default.
- W4319315709 cites W1989228404 @default.
- W4319315709 cites W1992192767 @default.
- W4319315709 cites W1999055779 @default.
- W4319315709 cites W2000677722 @default.
- W4319315709 cites W2001330064 @default.
- W4319315709 cites W2015642465 @default.
- W4319315709 cites W2018518196 @default.
- W4319315709 cites W2029667189 @default.
- W4319315709 cites W2035266068 @default.
- W4319315709 cites W2038426583 @default.
- W4319315709 cites W2050270735 @default.
- W4319315709 cites W2055172284 @default.
- W4319315709 cites W2063237304 @default.
- W4319315709 cites W2064897680 @default.
- W4319315709 cites W2067513135 @default.
- W4319315709 cites W2074986801 @default.
- W4319315709 cites W2087019753 @default.
- W4319315709 cites W2093646741 @default.
- W4319315709 cites W2095487531 @default.
- W4319315709 cites W2097606916 @default.
- W4319315709 cites W2102993309 @default.
- W4319315709 cites W2103575474 @default.
- W4319315709 cites W2104178065 @default.
- W4319315709 cites W2113140044 @default.
- W4319315709 cites W2116038472 @default.
- W4319315709 cites W2119497560 @default.
- W4319315709 cites W2128890791 @default.
- W4319315709 cites W2133579817 @default.
- W4319315709 cites W2145454207 @default.
- W4319315709 cites W2147993766 @default.
- W4319315709 cites W2159482845 @default.
- W4319315709 cites W2162792752 @default.
- W4319315709 cites W2170146596 @default.
- W4319315709 cites W2332712348 @default.
- W4319315709 cites W2441674845 @default.
- W4319315709 cites W2577594514 @default.
- W4319315709 cites W2605557839 @default.
- W4319315709 cites W2741358468 @default.
- W4319315709 cites W2758910468 @default.
- W4319315709 cites W2765915958 @default.
- W4319315709 cites W2773653044 @default.
- W4319315709 cites W2803029512 @default.
- W4319315709 cites W2950764390 @default.
- W4319315709 cites W2966803214 @default.
- W4319315709 cites W3026701861 @default.
- W4319315709 cites W4211156111 @default.
- W4319315709 cites W4256409604 @default.
- W4319315709 doi "https://doi.org/10.1016/j.jmgm.2023.108425" @default.
- W4319315709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36758328" @default.
- W4319315709 hasPublicationYear "2023" @default.
- W4319315709 type Work @default.
- W4319315709 citedByCount "0" @default.
- W4319315709 crossrefType "journal-article" @default.
- W4319315709 hasAuthorship W4319315709A5024210822 @default.
- W4319315709 hasAuthorship W4319315709A5036929679 @default.
- W4319315709 hasAuthorship W4319315709A5075143843 @default.
- W4319315709 hasConcept C121332964 @default.
- W4319315709 hasConcept C159047783 @default.
- W4319315709 hasConcept C159110408 @default.
- W4319315709 hasConcept C185592680 @default.
- W4319315709 hasConcept C2779528086 @default.
- W4319315709 hasConcept C2780823208 @default.
- W4319315709 hasConcept C41685203 @default.
- W4319315709 hasConcept C44000306 @default.
- W4319315709 hasConcept C70721500 @default.
- W4319315709 hasConcept C71924100 @default.
- W4319315709 hasConcept C74650414 @default.
- W4319315709 hasConcept C86803240 @default.
- W4319315709 hasConceptScore W4319315709C121332964 @default.
- W4319315709 hasConceptScore W4319315709C159047783 @default.
- W4319315709 hasConceptScore W4319315709C159110408 @default.
- W4319315709 hasConceptScore W4319315709C185592680 @default.
- W4319315709 hasConceptScore W4319315709C2779528086 @default.
- W4319315709 hasConceptScore W4319315709C2780823208 @default.
- W4319315709 hasConceptScore W4319315709C41685203 @default.
- W4319315709 hasConceptScore W4319315709C44000306 @default.
- W4319315709 hasConceptScore W4319315709C70721500 @default.
- W4319315709 hasConceptScore W4319315709C71924100 @default.
- W4319315709 hasConceptScore W4319315709C74650414 @default.
- W4319315709 hasConceptScore W4319315709C86803240 @default.
- W4319315709 hasLocation W43193157091 @default.
- W4319315709 hasLocation W43193157092 @default.
- W4319315709 hasOpenAccess W4319315709 @default.
- W4319315709 hasPrimaryLocation W43193157091 @default.
- W4319315709 hasRelatedWork W1975853978 @default.
- W4319315709 hasRelatedWork W2112236985 @default.
- W4319315709 hasRelatedWork W2117582146 @default.
- W4319315709 hasRelatedWork W2510934268 @default.