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- W4319316240 endingPage "373" @default.
- W4319316240 startingPage "373" @default.
- W4319316240 abstract "This review reports in detail the cellular and molecular mechanisms which regulate the bone remodeling process in relation to oxidative stress (OS), inflammatory factors, and estrogen deficiency. OS is considered an important pathogenic factor of osteoporosis, inducing osteocyte apoptosis and varying levels of specific factors, such as receptor activator κB ligand (RANKL), sclerostin, and, according to recent evidence, fibroblast growth factor 23, with consequent impairment of bone remodeling and high bone resorption. Bone loss increases the risk of fragility fractures, and the most commonly used treatments are antiresorptive drugs, followed by anabolic drugs or those with a double effect. In addition, recent data show that natural antioxidants contained in the diet are efficient in preventing and reducing the negative effects of OS on bone remodeling and osteocytes through the involvement of sirtuin type 1 enzyme. Indeed, osteocytes and some of their molecular factors are considered potential biological targets on which antioxidants can act to prevent and reduce bone loss, as well as to promote bone anabolic and regenerative processes by restoring physiological bone remodeling. Several data suggest including antioxidants in novel therapeutic approaches to develop better management strategies for the prevention and treatment of osteoporosis and OS-related bone diseases. In particular, anthocyanins, as well as resveratrol, lycopene, oleuropein, some vitamins, and thiol antioxidants, could have protective and therapeutic anti-osteoporotic effects." @default.
- W4319316240 created "2023-02-08" @default.
- W4319316240 creator A5024408605 @default.
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- W4319316240 creator A5085908135 @default.
- W4319316240 date "2023-02-03" @default.
- W4319316240 modified "2023-10-18" @default.
- W4319316240 title "Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches" @default.
- W4319316240 cites W1452872523 @default.
- W4319316240 cites W1513928844 @default.
- W4319316240 cites W1531070430 @default.
- W4319316240 cites W1548058762 @default.
- W4319316240 cites W1581565952 @default.
- W4319316240 cites W1587545842 @default.
- W4319316240 cites W1812976842 @default.
- W4319316240 cites W1874298169 @default.
- W4319316240 cites W1876124517 @default.
- W4319316240 cites W1897241050 @default.
- W4319316240 cites W1965084264 @default.
- W4319316240 cites W1967644150 @default.
- W4319316240 cites W1969305600 @default.
- W4319316240 cites W1971309308 @default.
- W4319316240 cites W1975233675 @default.
- W4319316240 cites W1975861458 @default.
- W4319316240 cites W1976408690 @default.
- W4319316240 cites W1978366029 @default.
- W4319316240 cites W1978511392 @default.
- W4319316240 cites W1978961990 @default.
- W4319316240 cites W1979851283 @default.
- W4319316240 cites W1980486821 @default.
- W4319316240 cites W1984626750 @default.
- W4319316240 cites W1984978318 @default.
- W4319316240 cites W1985449914 @default.
- W4319316240 cites W1988316550 @default.
- W4319316240 cites W1995251672 @default.
- W4319316240 cites W2001870522 @default.
- W4319316240 cites W2002949157 @default.
- W4319316240 cites W2004943901 @default.
- W4319316240 cites W2008816560 @default.
- W4319316240 cites W2011828467 @default.
- W4319316240 cites W2016390309 @default.
- W4319316240 cites W2019582558 @default.
- W4319316240 cites W2020360423 @default.
- W4319316240 cites W2020958147 @default.
- W4319316240 cites W2022029297 @default.
- W4319316240 cites W2022822304 @default.
- W4319316240 cites W2025126521 @default.
- W4319316240 cites W2027144420 @default.
- W4319316240 cites W2028105165 @default.
- W4319316240 cites W2030136517 @default.
- W4319316240 cites W2031050297 @default.
- W4319316240 cites W2032247976 @default.
- W4319316240 cites W2038645339 @default.
- W4319316240 cites W2039223695 @default.
- W4319316240 cites W2041259441 @default.
- W4319316240 cites W2044250052 @default.
- W4319316240 cites W2047187088 @default.
- W4319316240 cites W2048480904 @default.
- W4319316240 cites W2054401277 @default.
- W4319316240 cites W2057329398 @default.
- W4319316240 cites W2061710919 @default.
- W4319316240 cites W2062145190 @default.
- W4319316240 cites W2062652295 @default.
- W4319316240 cites W2066127490 @default.
- W4319316240 cites W2070195200 @default.
- W4319316240 cites W2073570745 @default.
- W4319316240 cites W2074676392 @default.
- W4319316240 cites W2075430806 @default.
- W4319316240 cites W2077095919 @default.
- W4319316240 cites W2077692700 @default.
- W4319316240 cites W2078470958 @default.
- W4319316240 cites W2078759546 @default.
- W4319316240 cites W2080295556 @default.
- W4319316240 cites W2082634363 @default.
- W4319316240 cites W2085702556 @default.
- W4319316240 cites W2088032325 @default.
- W4319316240 cites W2092222515 @default.
- W4319316240 cites W2100297973 @default.
- W4319316240 cites W2102290498 @default.
- W4319316240 cites W2102347237 @default.
- W4319316240 cites W2109300910 @default.
- W4319316240 cites W2112757808 @default.
- W4319316240 cites W2118249767 @default.
- W4319316240 cites W2118312317 @default.
- W4319316240 cites W2119360582 @default.
- W4319316240 cites W2121839388 @default.
- W4319316240 cites W2123346255 @default.
- W4319316240 cites W2126873568 @default.
- W4319316240 cites W2130807386 @default.
- W4319316240 cites W2131332344 @default.
- W4319316240 cites W2138754612 @default.
- W4319316240 cites W2142405038 @default.
- W4319316240 cites W2142433861 @default.
- W4319316240 cites W2144220745 @default.
- W4319316240 cites W2147441944 @default.