FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319319397> ?p ?o ?g. }

• W4319319397 endingPage "1018" @default.
• W4319319397 startingPage "1018" @default.
• W4319319397 abstract "Over the last 10 years, the traditional treatment paradigms for CLL have been upended as the use of traditional chemoimmunotherapy regimens has declined in favor of novel targeted therapies. Targeted therapies have become the new standard of care in CLL given their superior progression-free survival (and overall survival, in some cases) when compared with chemoimmunotherapy, as well as their improved toxicity profiles. Targeted agents are FDA approved for the treatment of CLL including ibrutinib, acalabrutinib, zanubrutinib, and venetoclax. Importantly, as opposed to traditional chemotherapy regimens, the benefits of these targeted therapies appear to be consistent regardless of high-risk mutational status. In this review, we discuss the pivotal CLL studies of the last decade and the data supporting doublet and triplet novel-novel combinations. We explore the use of new surrogate end points for PFS/OS in targeted therapies such as undetectable minimal residual disease (uMRD) and their potential role in minimizing toxicity by permitting earlier treatment discontinuation. We also highlight areas that warrant further exploration and future studies that may help address some of these key questions." @default.
• W4319319397 created "2023-02-08" @default.
• W4319319397 creator A5033372610 @default.
• W4319319397 creator A5042723532 @default.
• W4319319397 date "2023-02-06" @default.
• W4319319397 modified "2023-10-18" @default.
• W4319319397 title "A History of Targeted Therapy Development and Progress in Novel–Novel Combinations for Chronic Lymphocytic Leukemia (CLL)" @default.
• W4319319397 cites W2071549499 @default.
• W4319319397 cites W2140606816 @default.
• W4319319397 cites W2169269721 @default.
• W4319319397 cites W2233614027 @default.
• W4319319397 cites W2369297677 @default.
• W4319319397 cites W2396328865 @default.
• W4319319397 cites W2590154459 @default.
• W4319319397 cites W2602893476 @default.
• W4319319397 cites W2787916641 @default.
• W4319319397 cites W2792666902 @default.
• W4319319397 cites W2902484351 @default.
• W4319319397 cites W2902706178 @default.
• W4319319397 cites W2946882253 @default.
• W4319319397 cites W2948436219 @default.
• W4319319397 cites W2966190920 @default.
• W4319319397 cites W2973195462 @default.
• W4319319397 cites W2991651263 @default.
• W4319319397 cites W3014464029 @default.
• W4319319397 cites W3016001018 @default.
• W4319319397 cites W3095374694 @default.
• W4319319397 cites W3095485612 @default.
• W4319319397 cites W3097908862 @default.
• W4319319397 cites W3185756680 @default.
• W4319319397 cites W3201468520 @default.
• W4319319397 cites W3208067790 @default.
• W4319319397 cites W3208680410 @default.
• W4319319397 cites W3212937433 @default.
• W4319319397 cites W4205825534 @default.
• W4319319397 cites W4205969691 @default.
• W4319319397 cites W4206273039 @default.
• W4319319397 cites W4212822472 @default.
• W4319319397 cites W4213453359 @default.
• W4319319397 cites W4223904810 @default.
• W4319319397 cites W4224138250 @default.
• W4319319397 cites W4225471076 @default.
• W4319319397 cites W4280503361 @default.
• W4319319397 cites W4281784552 @default.
• W4319319397 cites W4283369890 @default.
• W4319319397 cites W4284883545 @default.
• W4319319397 cites W4310093475 @default.
• W4319319397 cites W4310093690 @default.
• W4319319397 cites W4310124896 @default.
• W4319319397 cites W4310154319 @default.
• W4319319397 cites W4310159956 @default.
• W4319319397 cites W4311167108 @default.
• W4319319397 doi "https://doi.org/10.3390/cancers15041018" @default.
• W4319319397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36831364" @default.
• W4319319397 hasPublicationYear "2023" @default.
• W4319319397 type Work @default.
• W4319319397 citedByCount "2" @default.
• W4319319397 countsByYear W43193193972023 @default.
• W4319319397 crossrefType "journal-article" @default.
• W4319319397 hasAuthorship W4319319397A5033372610 @default.
• W4319319397 hasAuthorship W4319319397A5042723532 @default.
• W4319319397 hasBestOaLocation W43193193971 @default.
• W4319319397 hasConcept C121608353 @default.
• W4319319397 hasConcept C126322002 @default.
• W4319319397 hasConcept C143998085 @default.
• W4319319397 hasConcept C177713679 @default.
• W4319319397 hasConcept C2777938653 @default.
• W4319319397 hasConcept C2778461978 @default.
• W4319319397 hasConcept C2778715236 @default.
• W4319319397 hasConcept C2779675984 @default.
• W4319319397 hasConcept C2779823535 @default.
• W4319319397 hasConcept C2779878957 @default.
• W4319319397 hasConcept C2780790343 @default.
• W4319319397 hasConcept C2781230642 @default.
• W4319319397 hasConcept C2781442060 @default.
• W4319319397 hasConcept C535046627 @default.
• W4319319397 hasConcept C71924100 @default.
• W4319319397 hasConceptScore W4319319397C121608353 @default.
• W4319319397 hasConceptScore W4319319397C126322002 @default.
• W4319319397 hasConceptScore W4319319397C143998085 @default.
• W4319319397 hasConceptScore W4319319397C177713679 @default.
• W4319319397 hasConceptScore W4319319397C2777938653 @default.
• W4319319397 hasConceptScore W4319319397C2778461978 @default.
• W4319319397 hasConceptScore W4319319397C2778715236 @default.
• W4319319397 hasConceptScore W4319319397C2779675984 @default.
• W4319319397 hasConceptScore W4319319397C2779823535 @default.
• W4319319397 hasConceptScore W4319319397C2779878957 @default.
• W4319319397 hasConceptScore W4319319397C2780790343 @default.
• W4319319397 hasConceptScore W4319319397C2781230642 @default.
• W4319319397 hasConceptScore W4319319397C2781442060 @default.
• W4319319397 hasConceptScore W4319319397C535046627 @default.
• W4319319397 hasConceptScore W4319319397C71924100 @default.
• W4319319397 hasIssue "4" @default.
• W4319319397 hasLocation W43193193971 @default.
• W4319319397 hasLocation W43193193972 @default.
• W4319319397 hasLocation W43193193973 @default.
• W4319319397 hasLocation W43193193974 @default.
• W4319319397 hasOpenAccess W4319319397 @default.

• next