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• W4319319481 endingPage "1015" @default.
• W4319319481 startingPage "1015" @default.
• W4319319481 abstract "Richter Syndrome (RS) is defined as the development of an aggressive lymphoma in patients with a previous or simultaneous diagnosis of chronic lymphocytic leukemia (CLL). Two pathological variants of RS are recognized: diffuse large B-cell lymphoma (DLBCL)-type and Hodgkin lymphoma (HL)-type RS. Different molecular mechanisms may explain the pathogenesis of DLBCL-type RS, including genetic lesions, modifications of immune regulators, and B cell receptor (BCR) pathway hyperactivation. Limited data are available for HL-type RS, and its development has been reported to be similar to de novo HL. In this review, we focus on the immune-related pathogenesis and immune system dysfunction of RS, which are linked to BCR over-reactivity, altered function of the immune system due to the underlying CLL, and specific features of the RS tumor microenvironment. The standard of care of this disease consists in chemoimmunotherapy, eventually followed by stem cell transplantation, but limited possibilities are offered to chemo-resistant patients, who represent the majority of RS cases. In order to address this unmet clinical need, several immunotherapeutic approaches have been developed, namely T cell engagement obtained with bispecific antibodies, PD-1/PD-L1 immune checkpoint blockade by the use of monoclonal antibodies, selective drug delivery with antibody-drug conjugates, and targeting malignant cells with anti-CD19 chimeric antigen receptor-T cells." @default.
• W4319319481 created "2023-02-08" @default.
• W4319319481 creator A5041745367 @default.
• W4319319481 creator A5084053548 @default.
• W4319319481 creator A5088913264 @default.
• W4319319481 date "2023-02-05" @default.
• W4319319481 modified "2023-10-18" @default.
• W4319319481 title "Immunological Aspects of Richter Syndrome: From Immune Dysfunction to Immunotherapy" @default.
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