FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319320700> ?p ?o ?g. }

• W4319320700 abstract "Background There is limited information about diabetes and thyroid related autoantibodies in children with type 1 diabetes (T1D) or their siblings in Sri Lanka. Objectives To assess in T1D children and their unaffected siblings the prevalence of autoantibodies to (1) glutamic acid decarboxylase (GADA), insulinoma associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) using 3 Screen ICA™ (3-Screen) and individual ELISA assays; (2) insulin (IAA); and (3) thyroid peroxidase (TPOA), thyroglobulin (TgA) and the TSH receptor (TSHRA). Methods We selected - (a) consecutive T1D children, and (b) their unaffected siblings of both sexes, from the T1D Registry at Lady Ridgeway Hospital, Colombo. Results The median age (IQR) of 235 T1D children and 252 unaffected siblings was 11 (8.4, 13.2) and 9 (5.4, 14.9) years respectively, and the duration of T1D was 23 (7, 54) months. (1) T1D children (a) 79.1% were 3-Screen positive; (b) all 3-Screen positives were individual antibody positive (GADA in 74%; IA-2A 31.1%; ZnT8A 38.7%); (c) and were younger (p=0.01 vs 3-Screen negatives); (d) multiple autoantibodies were present in 45.1%; (e) IA-2A (p=0.002) and ZnT8A (p=0.006) prevalence decreased with T1D duration. (f) TPOA and TgA prevalence was higher in T1D children compared to unaffected siblings (28%, p=0.001 and 31%, p=0.004, respectively). (2) Unaffected siblings (a) 6.3% were 3-Screen positive (p=0.001 vs T1D), and 2.4% were positive for IAA; (b) four subjects had two diabetes related autoantibodies, one of whom developed dysglycaemia during follow-up. Conclusions The 3-Screen assay, used for the first time in Sri Lankan T1D children and their siblings as a screening tool, shows a high prevalence of T1D related Abs with a high correlation with individual assays, and is also a helpful tool in screening unaffected siblings for future T1D risk. The higher prevalence of thyroid autoantibodies in T1D children is consistent with polyglandular autoimmunity." @default.
• W4319320700 created "2023-02-08" @default.
• W4319320700 creator A5025809987 @default.
• W4319320700 creator A5030410833 @default.
• W4319320700 creator A5031290336 @default.
• W4319320700 creator A5045609433 @default.
• W4319320700 creator A5053086052 @default.
• W4319320700 creator A5055004417 @default.
• W4319320700 creator A5057598951 @default.
• W4319320700 creator A5080338852 @default.
• W4319320700 date "2023-02-06" @default.
• W4319320700 modified "2023-10-18" @default.
• W4319320700 title "The prevalence of diabetes and thyroid related autoantibodies in Sri Lankan children with type 1 diabetes and their unaffected siblings – The utility of a new screening assay" @default.
• W4319320700 cites W1825072539 @default.
• W4319320700 cites W1977807166 @default.
• W4319320700 cites W1987618009 @default.
• W4319320700 cites W2000549941 @default.
• W4319320700 cites W2015258305 @default.
• W4319320700 cites W2027613359 @default.
• W4319320700 cites W2030372846 @default.
• W4319320700 cites W2030685032 @default.
• W4319320700 cites W2037368117 @default.
• W4319320700 cites W2046889691 @default.
• W4319320700 cites W2049204060 @default.
• W4319320700 cites W2051883261 @default.
• W4319320700 cites W2062573090 @default.
• W4319320700 cites W2073806728 @default.
• W4319320700 cites W2095256598 @default.
• W4319320700 cites W2112458346 @default.
• W4319320700 cites W2115209313 @default.
• W4319320700 cites W2140028073 @default.
• W4319320700 cites W2158598357 @default.
• W4319320700 cites W2254940982 @default.
• W4319320700 cites W2308711820 @default.
• W4319320700 cites W2326904657 @default.
• W4319320700 cites W2516716435 @default.
• W4319320700 cites W2887854024 @default.
• W4319320700 cites W2966953002 @default.
• W4319320700 cites W2974354116 @default.
• W4319320700 cites W3028109119 @default.
• W4319320700 cites W3033566401 @default.
• W4319320700 cites W3040355694 @default.
• W4319320700 cites W3118566870 @default.
• W4319320700 cites W3155313777 @default.
• W4319320700 cites W3190719821 @default.
• W4319320700 cites W4210515214 @default.
• W4319320700 cites W4214767347 @default.
• W4319320700 cites W4229679643 @default.
• W4319320700 cites W46180886 @default.
• W4319320700 doi "https://doi.org/10.3389/fendo.2023.1028285" @default.
• W4319320700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36814577" @default.
• W4319320700 hasPublicationYear "2023" @default.
• W4319320700 type Work @default.
• W4319320700 citedByCount "0" @default.
• W4319320700 crossrefType "journal-article" @default.
• W4319320700 hasAuthorship W4319320700A5025809987 @default.
• W4319320700 hasAuthorship W4319320700A5030410833 @default.
• W4319320700 hasAuthorship W4319320700A5031290336 @default.
• W4319320700 hasAuthorship W4319320700A5045609433 @default.
• W4319320700 hasAuthorship W4319320700A5053086052 @default.
• W4319320700 hasAuthorship W4319320700A5055004417 @default.
• W4319320700 hasAuthorship W4319320700A5057598951 @default.
• W4319320700 hasAuthorship W4319320700A5080338852 @default.
• W4319320700 hasBestOaLocation W43193207001 @default.
• W4319320700 hasConcept C126322002 @default.
• W4319320700 hasConcept C134018914 @default.
• W4319320700 hasConcept C159654299 @default.
• W4319320700 hasConcept C163764329 @default.
• W4319320700 hasConcept C180650514 @default.
• W4319320700 hasConcept C187212893 @default.
• W4319320700 hasConcept C203014093 @default.
• W4319320700 hasConcept C2781232474 @default.
• W4319320700 hasConcept C526584372 @default.
• W4319320700 hasConcept C555293320 @default.
• W4319320700 hasConcept C71924100 @default.
• W4319320700 hasConcept C90924648 @default.
• W4319320700 hasConceptScore W4319320700C126322002 @default.
• W4319320700 hasConceptScore W4319320700C134018914 @default.
• W4319320700 hasConceptScore W4319320700C159654299 @default.
• W4319320700 hasConceptScore W4319320700C163764329 @default.
• W4319320700 hasConceptScore W4319320700C180650514 @default.
• W4319320700 hasConceptScore W4319320700C187212893 @default.
• W4319320700 hasConceptScore W4319320700C203014093 @default.
• W4319320700 hasConceptScore W4319320700C2781232474 @default.
• W4319320700 hasConceptScore W4319320700C526584372 @default.
• W4319320700 hasConceptScore W4319320700C555293320 @default.
• W4319320700 hasConceptScore W4319320700C71924100 @default.
• W4319320700 hasConceptScore W4319320700C90924648 @default.
• W4319320700 hasLocation W43193207001 @default.
• W4319320700 hasLocation W43193207002 @default.
• W4319320700 hasLocation W43193207003 @default.
• W4319320700 hasLocation W43193207004 @default.
• W4319320700 hasLocation W43193207005 @default.
• W4319320700 hasOpenAccess W4319320700 @default.
• W4319320700 hasPrimaryLocation W43193207001 @default.
• W4319320700 hasRelatedWork W1972113515 @default.
• W4319320700 hasRelatedWork W1981968121 @default.
• W4319320700 hasRelatedWork W2010645160 @default.
• W4319320700 hasRelatedWork W2011960454 @default.
• W4319320700 hasRelatedWork W2060603500 @default.

• next