Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319320757> ?p ?o ?g. }
- W4319320757 endingPage "1535" @default.
- W4319320757 startingPage "1535" @default.
- W4319320757 abstract "Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible. The profiling was therefore improved to allow for the detection of individual bioactive compounds, and the range of samples was extended to 15 commercial golden root products. Further effect-directed assays were studied providing information on 15 different effect mechanisms, i.e., (1) tyrosinase, (2) acetylcholinesterase, (3) butyrylcholinesterase, (4) β-glucuronidase, and (5) α-amylase inhibition, as well as endocrine activity via the triplex planar yeast antagonist-verified (6–8) estrogen or (9–11) androgen screen, (12) genotoxicity via the planar SOS-Umu-C bioassay, antimicrobial activity against (13) Gram-negative Aliivibrio fischeri and (14) Gram-positive Bacillus subtilis bacteria, and (15) antioxidative activity (DPPH• radical scavengers). Most of the golden root profiles obtained were characteristic, but some samples differed substantially. The United States Pharmacopeia reference product showed medium activity in most of the assays. The six most active compound zones were further characterized using high-resolution mass spectrometry, and the mass signals obtained were tentatively assigned to molecular formulae. In addition to confirming the known activities, this study is the first to report that golden root constituents inhibit butyrylcholinesterase (rosin was tentatively assigned), β-glucuronidase (rosavin, rosarin, rosiridin, viridoside, and salidroside were tentatively assigned), and α-amylase (stearic acid and palmitic acid were tentatively assigned) and that they are genotoxic (hydroquinone was tentatively assigned) and are both agonistic and antagonistic endocrine active." @default.
- W4319320757 created "2023-02-08" @default.
- W4319320757 creator A5030195699 @default.
- W4319320757 creator A5050538759 @default.
- W4319320757 creator A5067072272 @default.
- W4319320757 date "2023-02-05" @default.
- W4319320757 modified "2023-10-12" @default.
- W4319320757 title "Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden Root Products via High-Performance Thin-Layer Chromatography, Planar Assays, and High-Resolution Mass Spectrometry" @default.
- W4319320757 cites W1155888672 @default.
- W4319320757 cites W1545271465 @default.
- W4319320757 cites W1679518225 @default.
- W4319320757 cites W1896829297 @default.
- W4319320757 cites W1969121210 @default.
- W4319320757 cites W1973607448 @default.
- W4319320757 cites W1982590568 @default.
- W4319320757 cites W1994101653 @default.
- W4319320757 cites W2030553271 @default.
- W4319320757 cites W2046001857 @default.
- W4319320757 cites W2075920812 @default.
- W4319320757 cites W2081275889 @default.
- W4319320757 cites W2081912789 @default.
- W4319320757 cites W2093967541 @default.
- W4319320757 cites W2118844654 @default.
- W4319320757 cites W2119360807 @default.
- W4319320757 cites W2119805697 @default.
- W4319320757 cites W2121741176 @default.
- W4319320757 cites W2152491909 @default.
- W4319320757 cites W2199119687 @default.
- W4319320757 cites W2205380200 @default.
- W4319320757 cites W2235660943 @default.
- W4319320757 cites W2287368380 @default.
- W4319320757 cites W2332869036 @default.
- W4319320757 cites W2399961654 @default.
- W4319320757 cites W2499561515 @default.
- W4319320757 cites W2538447549 @default.
- W4319320757 cites W2571027214 @default.
- W4319320757 cites W2754395355 @default.
- W4319320757 cites W2773849547 @default.
- W4319320757 cites W2884887063 @default.
- W4319320757 cites W2890247074 @default.
- W4319320757 cites W2899132120 @default.
- W4319320757 cites W2900431096 @default.
- W4319320757 cites W2943932402 @default.
- W4319320757 cites W2945561332 @default.
- W4319320757 cites W2982855932 @default.
- W4319320757 cites W3032516979 @default.
- W4319320757 cites W3045784015 @default.
- W4319320757 cites W3093753665 @default.
- W4319320757 cites W3114671042 @default.
- W4319320757 cites W3118984784 @default.
- W4319320757 cites W3119667254 @default.
- W4319320757 cites W3158865612 @default.
- W4319320757 cites W3170793535 @default.
- W4319320757 cites W3195634909 @default.
- W4319320757 cites W4200099634 @default.
- W4319320757 cites W4281738161 @default.
- W4319320757 cites W4293771331 @default.
- W4319320757 cites W4310554078 @default.
- W4319320757 doi "https://doi.org/10.3390/molecules28041535" @default.
- W4319320757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36838523" @default.
- W4319320757 hasPublicationYear "2023" @default.
- W4319320757 type Work @default.
- W4319320757 citedByCount "1" @default.
- W4319320757 countsByYear W43193207572023 @default.
- W4319320757 crossrefType "journal-article" @default.
- W4319320757 hasAuthorship W4319320757A5030195699 @default.
- W4319320757 hasAuthorship W4319320757A5050538759 @default.
- W4319320757 hasAuthorship W4319320757A5067072272 @default.
- W4319320757 hasBestOaLocation W43193207571 @default.
- W4319320757 hasConcept C185592680 @default.
- W4319320757 hasConcept C2777263532 @default.
- W4319320757 hasConcept C2778004101 @default.
- W4319320757 hasConcept C2781263971 @default.
- W4319320757 hasConcept C43617362 @default.
- W4319320757 hasConcept C55493867 @default.
- W4319320757 hasConcept C71240020 @default.
- W4319320757 hasConceptScore W4319320757C185592680 @default.
- W4319320757 hasConceptScore W4319320757C2777263532 @default.
- W4319320757 hasConceptScore W4319320757C2778004101 @default.
- W4319320757 hasConceptScore W4319320757C2781263971 @default.
- W4319320757 hasConceptScore W4319320757C43617362 @default.
- W4319320757 hasConceptScore W4319320757C55493867 @default.
- W4319320757 hasConceptScore W4319320757C71240020 @default.
- W4319320757 hasFunder F4320320879 @default.
- W4319320757 hasIssue "4" @default.
- W4319320757 hasLocation W43193207571 @default.
- W4319320757 hasLocation W43193207572 @default.
- W4319320757 hasLocation W43193207573 @default.
- W4319320757 hasOpenAccess W4319320757 @default.
- W4319320757 hasPrimaryLocation W43193207571 @default.
- W4319320757 hasRelatedWork W1973125040 @default.
- W4319320757 hasRelatedWork W2025219248 @default.
- W4319320757 hasRelatedWork W2043619894 @default.
- W4319320757 hasRelatedWork W2047079897 @default.
- W4319320757 hasRelatedWork W2062381920 @default.
- W4319320757 hasRelatedWork W2094764677 @default.
- W4319320757 hasRelatedWork W2372297077 @default.
- W4319320757 hasRelatedWork W2379976244 @default.