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• W4319333302 abstract "To evaluate clinicopathologic characteristics of biclonal chronic lymphocytic leukemia (CLL).Retrospectively analyze clinical data and pathologic features.Ten cases were identified in which flow cytometry demonstrated an abnormal B-cell population with a CLL-like immunophenotype but showed no definitive light chain restriction. All had cytogenetic abnormalities detected, including seven with two CLL-related abnormalities. Four of these showed features suggestive of clonal evolution, all having del(13q) as a stem-line abnormality and three showing del(11q) as a side-line abnormality. Five (50%) cases demonstrated deleterious NOTCH1 mutations, in contrast to 11.8% in a control group of monoclonal CLL (P < .05). Of the 10 patients, 5 received treatment, with good/partial response in three cases and therapeutic resistance in one case. The median treatment-free survival was estimated at 68 months.Despite a polytypic pattern of light chain expression, the neoplastic nature of biclonal CLL is suggested by a characteristic CLL phenotype and can be confirmed by cytogenetic and genomic analyses. The two clones with discordant light chain isotypes may share a stem-line cytogenetic abnormality, suggesting possible clonal evolution. Biclonal CLL is associated with NOTCH1 mutations, which may occur in a small subclone and gradually evolve in clonal size. Genomic analysis on light chain-sorted and/or chronologically collected samples may provide insight into clonal evolution in CLL." @default.
• W4319333302 created "2023-02-08" @default.
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• W4319333302 date "2023-02-07" @default.
• W4319333302 modified "2023-09-30" @default.
• W4319333302 title "Chronic Lymphocytic Leukemia With Two B-Cell Populations of Discordant Light Chain Restrictions in Individual Patients" @default.
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• W4319333302 doi "https://doi.org/10.1093/ajcp/aqac165" @default.
• W4319333302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36749322" @default.
• W4319333302 hasPublicationYear "2023" @default.
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