FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319333376> ?p ?o ?g. }

• W4319333376 endingPage "1213" @default.
• W4319333376 startingPage "1203" @default.
• W4319333376 abstract "Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct DNA methylation profiles have been shown to be associated with the mutually exclusive SPOP-mutant or TMPRSS2-ERG fusion genetic backgrounds. Using a cohort of prostate cancer brain metastases (PCBM) from 42 patients, with matched primary tumors for 17 patients, we carried out a DNA methylation analysis to examine the epigenetic distinction between primary prostate cancer and PCBM, the association between epigenetic alterations and mutational background, and particular epigenetic alterations that may be associated with PCBM. Multiregion sampling of PCBM revealed epigenetic stability within metastases. Aberrant methylation in PCBM was associated with mutational background and PRC2 complex activity, an effect that is particularly pronounced in SPOP-mutant PCBM. While PCBM displayed a CpG island hypermethylator phenotype, hypomethylation at the promoters of genes involved in neuroactive ligand-receptor interaction and cell adhesion molecules such as GABRB3, CLDN8, and CLDN4 was also observed, suggesting that cells from primary tumors may require specific reprogramming to form brain metastasis. This study revealed the DNA methylation landscapes of PCBM and the potential mechanisms and effects of PCBM-associated aberrant DNA methylation.DNA methylation analysis reveals the molecular characteristics of PCBM and may serve as a starting point for efforts to identify and target susceptibilities of these rare metastases." @default.
• W4319333376 created "2023-02-08" @default.
• W4319333376 creator A5000570624 @default.
• W4319333376 creator A5008571973 @default.
• W4319333376 creator A5008614237 @default.
• W4319333376 creator A5009101766 @default.
• W4319333376 creator A5009944943 @default.
• W4319333376 creator A5019107852 @default.
• W4319333376 creator A5022447574 @default.
• W4319333376 creator A5030105260 @default.
• W4319333376 creator A5035068594 @default.
• W4319333376 creator A5035484907 @default.
• W4319333376 creator A5044490149 @default.
• W4319333376 creator A5051087530 @default.
• W4319333376 creator A5057848295 @default.
• W4319333376 creator A5062173340 @default.
• W4319333376 creator A5070251257 @default.
• W4319333376 creator A5073639936 @default.
• W4319333376 creator A5073753205 @default.
• W4319333376 creator A5076510325 @default.
• W4319333376 creator A5077404628 @default.
• W4319333376 creator A5081827829 @default.
• W4319333376 creator A5085033451 @default.
• W4319333376 creator A5085318253 @default.
• W4319333376 creator A5085508858 @default.
• W4319333376 date "2023-02-07" @default.
• W4319333376 modified "2023-10-01" @default.
• W4319333376 title "DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations" @default.
• W4319333376 cites W1578291413 @default.
• W4319333376 cites W1994847090 @default.
• W4319333376 cites W2011670486 @default.
• W4319333376 cites W2021647295 @default.
• W4319333376 cites W2034879676 @default.
• W4319333376 cites W2080742369 @default.
• W4319333376 cites W2101870168 @default.
• W4319333376 cites W2102983187 @default.
• W4319333376 cites W2115462905 @default.
• W4319333376 cites W2121158863 @default.
• W4319333376 cites W2131478115 @default.
• W4319333376 cites W2146512944 @default.
• W4319333376 cites W2161112598 @default.
• W4319333376 cites W2170830174 @default.
• W4319333376 cites W2230320310 @default.
• W4319333376 cites W2261451134 @default.
• W4319333376 cites W2288877165 @default.
• W4319333376 cites W2560633994 @default.
• W4319333376 cites W2587831721 @default.
• W4319333376 cites W2610636284 @default.
• W4319333376 cites W2745417329 @default.
• W4319333376 cites W2796153844 @default.
• W4319333376 cites W2884001931 @default.
• W4319333376 cites W2897187982 @default.
• W4319333376 cites W2914700206 @default.
• W4319333376 cites W2921264463 @default.
• W4319333376 cites W2943730836 @default.
• W4319333376 cites W2990053395 @default.
• W4319333376 cites W2995530523 @default.
• W4319333376 cites W2998673592 @default.
• W4319333376 cites W3006500278 @default.
• W4319333376 cites W3010648998 @default.
• W4319333376 cites W3041912701 @default.
• W4319333376 cites W3042758458 @default.
• W4319333376 cites W3085873496 @default.
• W4319333376 cites W3091857697 @default.
• W4319333376 cites W3094674567 @default.
• W4319333376 cites W3119108208 @default.
• W4319333376 cites W3168723030 @default.
• W4319333376 cites W3168958685 @default.
• W4319333376 cites W3173779735 @default.
• W4319333376 cites W3186425351 @default.
• W4319333376 cites W3217808929 @default.
• W4319333376 cites W4225391739 @default.
• W4319333376 cites W4225766687 @default.
• W4319333376 doi "https://doi.org/10.1158/0008-5472.can-22-2236" @default.
• W4319333376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36749655" @default.
• W4319333376 hasPublicationYear "2023" @default.
• W4319333376 type Work @default.
• W4319333376 citedByCount "1" @default.
• W4319333376 countsByYear W43193333762023 @default.
• W4319333376 crossrefType "journal-article" @default.
• W4319333376 hasAuthorship W4319333376A5000570624 @default.
• W4319333376 hasAuthorship W4319333376A5008571973 @default.
• W4319333376 hasAuthorship W4319333376A5008614237 @default.
• W4319333376 hasAuthorship W4319333376A5009101766 @default.
• W4319333376 hasAuthorship W4319333376A5009944943 @default.
• W4319333376 hasAuthorship W4319333376A5019107852 @default.
• W4319333376 hasAuthorship W4319333376A5022447574 @default.
• W4319333376 hasAuthorship W4319333376A5030105260 @default.
• W4319333376 hasAuthorship W4319333376A5035068594 @default.
• W4319333376 hasAuthorship W4319333376A5035484907 @default.
• W4319333376 hasAuthorship W4319333376A5044490149 @default.
• W4319333376 hasAuthorship W4319333376A5051087530 @default.
• W4319333376 hasAuthorship W4319333376A5057848295 @default.
• W4319333376 hasAuthorship W4319333376A5062173340 @default.
• W4319333376 hasAuthorship W4319333376A5070251257 @default.
• W4319333376 hasAuthorship W4319333376A5073639936 @default.
• W4319333376 hasAuthorship W4319333376A5073753205 @default.
• W4319333376 hasAuthorship W4319333376A5076510325 @default.

• next