FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319334094> ?p ?o ?g. }

• W4319334094 endingPage "1337" @default.
• W4319334094 startingPage "1325" @default.
• W4319334094 abstract "The polypeptide PGlyAlaGlu was prepared with 20 mol % glycine (Gly), 36 mol % d,l-alanine (Ala), and 44 mol % d,l-glutamic acid (Glu) and labeled with the dye 1-pyrenemethylamine to yield a series of Py-PGlyAlaGlu samples. The fluorescence decays of the Py-PGlyAlaGlu samples were analyzed according to the fluorescence blob model (FBM) to obtain the number Nblobexp of amino acids (aa's) encompassed inside the subvolume Vblob of the polypeptide probed by an excited pyrene. An Nblobexp value of 29 (±2) was retrieved for Py-PGlyAlaGlu, which was much larger than for any of the copolypeptide PGlyGlu or PAlaGlu prepared with either Gly and Glu or Ala and Glu, respectively. The continuous increase in Nblobexp with decreasing side chain size (SCS) from 10 aa's for PGlu to 16 aa's for PAlaGlu and 22 aa's for PGlyGlu was used earlier to define the reach of an aa and determine the groups of aa's that could interact with each other along a polypeptide backbone according to their SCS. These groups of aa's, referred to as blobs, led to the implementation of blob-based models (BBM) to predict the folding time τFtheo,BBM of 145 proteins, which was found to match their experimental folding time τFexp with a relatively high 0.71 correlation coefficient. Nevertheless, the much higher Nblobexp value found for Py-PGlyAlaGlu compared to all other pyrene-labeled polypeptides studied to date indicates that the reach of aa's along a polypeptide sequence is affected not only by SCS but also by synergetic effects between different aa's. Following this new insight, a revised BBM was implemented to predict τFtheo,BBM for 195 proteins assuming the existence or absence of synergies to control the interactions between aa's along a polypeptide sequence. Similarly good correlation coefficients of 0.71 and 0.74 were obtained for a direct 1:1 comparison of τFexp and τFtheo,BBM for the 195 proteins without and with synergies, respectively. This result suggests that synergetic effects between different aa's have little effect on τFtheo,BBM predicted from BBM underlying the robustness of this methodology." @default.
• W4319334094 created "2023-02-08" @default.
• W4319334094 creator A5030214110 @default.
• W4319334094 creator A5085165441 @default.
• W4319334094 date "2023-02-07" @default.
• W4319334094 modified "2023-10-14" @default.
• W4319334094 title "Synergetic Effects of Alanine and Glycine in Blob-Based Methods for Predicting Protein Folding Times" @default.
• W4319334094 cites W1843397982 @default.
• W4319334094 cites W1970966964 @default.
• W4319334094 cites W1973501490 @default.
• W4319334094 cites W1974621200 @default.
• W4319334094 cites W1987451605 @default.
• W4319334094 cites W1987482901 @default.
• W4319334094 cites W1987654889 @default.
• W4319334094 cites W1990771740 @default.
• W4319334094 cites W1991921179 @default.
• W4319334094 cites W2007415752 @default.
• W4319334094 cites W2015383521 @default.
• W4319334094 cites W2021654520 @default.
• W4319334094 cites W2025289825 @default.
• W4319334094 cites W2026205393 @default.
• W4319334094 cites W2039220557 @default.
• W4319334094 cites W2048452697 @default.
• W4319334094 cites W2063237839 @default.
• W4319334094 cites W2063870542 @default.
• W4319334094 cites W2067987181 @default.
• W4319334094 cites W2068396352 @default.
• W4319334094 cites W2077864453 @default.
• W4319334094 cites W2085720059 @default.
• W4319334094 cites W2089597488 @default.
• W4319334094 cites W2092227167 @default.
• W4319334094 cites W2093701091 @default.
• W4319334094 cites W2104704906 @default.
• W4319334094 cites W2105880172 @default.
• W4319334094 cites W2112444949 @default.
• W4319334094 cites W2121529915 @default.
• W4319334094 cites W2123132657 @default.
• W4319334094 cites W2129020329 @default.
• W4319334094 cites W2133313421 @default.
• W4319334094 cites W2139433006 @default.
• W4319334094 cites W2143268609 @default.
• W4319334094 cites W2159956992 @default.
• W4319334094 cites W2165222310 @default.
• W4319334094 cites W2199928338 @default.
• W4319334094 cites W2313235060 @default.
• W4319334094 cites W2335455153 @default.
• W4319334094 cites W2518539871 @default.
• W4319334094 cites W2793216035 @default.
• W4319334094 cites W2801589934 @default.
• W4319334094 cites W2809682566 @default.
• W4319334094 cites W2912360054 @default.
• W4319334094 cites W3004537654 @default.
• W4319334094 cites W3037907389 @default.
• W4319334094 cites W3046172836 @default.
• W4319334094 cites W3099876786 @default.
• W4319334094 cites W3104057007 @default.
• W4319334094 cites W3119435080 @default.
• W4319334094 cites W3176361845 @default.
• W4319334094 cites W3200182613 @default.
• W4319334094 cites W4221075966 @default.
• W4319334094 cites W4293217134 @default.
• W4319334094 doi "https://doi.org/10.1021/acs.jpcb.2c08155" @default.
• W4319334094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36749707" @default.
• W4319334094 hasPublicationYear "2023" @default.
• W4319334094 type Work @default.
• W4319334094 citedByCount "2" @default.
• W4319334094 countsByYear W43193340942023 @default.
• W4319334094 crossrefType "journal-article" @default.
• W4319334094 hasAuthorship W4319334094A5030214110 @default.
• W4319334094 hasAuthorship W4319334094A5085165441 @default.
• W4319334094 hasConcept C119599485 @default.
• W4319334094 hasConcept C121332964 @default.
• W4319334094 hasConcept C127413603 @default.
• W4319334094 hasConcept C134121241 @default.
• W4319334094 hasConcept C178790620 @default.
• W4319334094 hasConcept C185592680 @default.
• W4319334094 hasConcept C191897082 @default.
• W4319334094 hasConcept C192562407 @default.
• W4319334094 hasConcept C2776545253 @default.
• W4319334094 hasConcept C2777756961 @default.
• W4319334094 hasConcept C2778740566 @default.
• W4319334094 hasConcept C2778951431 @default.
• W4319334094 hasConcept C2779856020 @default.
• W4319334094 hasConcept C515207424 @default.
• W4319334094 hasConcept C55493867 @default.
• W4319334094 hasConcept C62520636 @default.
• W4319334094 hasConcept C71240020 @default.
• W4319334094 hasConcept C8010536 @default.
• W4319334094 hasConcept C91881484 @default.
• W4319334094 hasConceptScore W4319334094C119599485 @default.
• W4319334094 hasConceptScore W4319334094C121332964 @default.
• W4319334094 hasConceptScore W4319334094C127413603 @default.
• W4319334094 hasConceptScore W4319334094C134121241 @default.
• W4319334094 hasConceptScore W4319334094C178790620 @default.
• W4319334094 hasConceptScore W4319334094C185592680 @default.
• W4319334094 hasConceptScore W4319334094C191897082 @default.
• W4319334094 hasConceptScore W4319334094C192562407 @default.
• W4319334094 hasConceptScore W4319334094C2776545253 @default.

• next