Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319341258> ?p ?o ?g. }
- W4319341258 abstract "TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium-dependent 1A (PPM1A) has been reported as a phosphatase of SMAD2 and regulates TGF-β signaling, while the role of PPM1A in cartilage homeostasis and OA development remains largely unexplored. In this study, we found increased PPM1A expression in OA chondrocytes and confirmed the interaction between PPM1A and phospho-SMAD2 (p-SMAD2). Importantly, our data show that PPM1A KO substantially protected mice treated with destabilization of medial meniscus (DMM) surgery against cartilage degeneration and subchondral sclerosis. Additionally, PPM1A ablation reduced the cartilage catabolism and cell apoptosis after the DMM operation. Moreover, p-SMAD2 expression in chondrocytes from KO mice was higher than that in WT controls with DMM induction. However, intraarticular injection with SD-208, repressing TGF-β/SMAD2 signaling, dramatically abolished protective phenotypes in PPM1A-KO mice. Finally, a specific pharmacologic PPM1A inhibitor, Sanguinarine chloride (SC) or BC-21, was able to ameliorate OA severity in C57BL/6J mice. In summary, our study identified PPM1A as a pivotal regulator of cartilage homeostasis and demonstrated that PPM1A inhibition attenuates OA progression via regulating TGF-β/SMAD2 signaling in chondrocytes and provided PPM1A as a potential target for OA treatment." @default.
- W4319341258 created "2023-02-08" @default.
- W4319341258 creator A5023872965 @default.
- W4319341258 creator A5031363665 @default.
- W4319341258 creator A5031574868 @default.
- W4319341258 creator A5032079976 @default.
- W4319341258 creator A5050038706 @default.
- W4319341258 creator A5055155526 @default.
- W4319341258 creator A5055740291 @default.
- W4319341258 creator A5056739139 @default.
- W4319341258 creator A5056937076 @default.
- W4319341258 creator A5071615222 @default.
- W4319341258 creator A5074669575 @default.
- W4319341258 creator A5077067783 @default.
- W4319341258 creator A5080870673 @default.
- W4319341258 creator A5089611506 @default.
- W4319341258 date "2023-02-08" @default.
- W4319341258 modified "2023-10-18" @default.
- W4319341258 title "Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes" @default.
- W4319341258 cites W1487514468 @default.
- W4319341258 cites W1627585603 @default.
- W4319341258 cites W1895912976 @default.
- W4319341258 cites W1964456021 @default.
- W4319341258 cites W1973173403 @default.
- W4319341258 cites W1977341692 @default.
- W4319341258 cites W2002251686 @default.
- W4319341258 cites W2034779933 @default.
- W4319341258 cites W2047347943 @default.
- W4319341258 cites W2049463960 @default.
- W4319341258 cites W2051790985 @default.
- W4319341258 cites W2060951121 @default.
- W4319341258 cites W2061261019 @default.
- W4319341258 cites W2067838033 @default.
- W4319341258 cites W2072370566 @default.
- W4319341258 cites W2082274436 @default.
- W4319341258 cites W2088091987 @default.
- W4319341258 cites W2088559146 @default.
- W4319341258 cites W2109118586 @default.
- W4319341258 cites W2110094917 @default.
- W4319341258 cites W2123267249 @default.
- W4319341258 cites W2128275386 @default.
- W4319341258 cites W2143643928 @default.
- W4319341258 cites W2158652866 @default.
- W4319341258 cites W2161629050 @default.
- W4319341258 cites W2462288202 @default.
- W4319341258 cites W2462526312 @default.
- W4319341258 cites W2530671957 @default.
- W4319341258 cites W2782804285 @default.
- W4319341258 cites W2802957489 @default.
- W4319341258 cites W2895994828 @default.
- W4319341258 cites W2898132166 @default.
- W4319341258 cites W2908775066 @default.
- W4319341258 cites W2944137118 @default.
- W4319341258 cites W2965332892 @default.
- W4319341258 cites W2989683811 @default.
- W4319341258 cites W2991427844 @default.
- W4319341258 cites W2995111932 @default.
- W4319341258 cites W3000036091 @default.
- W4319341258 cites W3040342671 @default.
- W4319341258 cites W3044572315 @default.
- W4319341258 cites W3095012295 @default.
- W4319341258 cites W3096429227 @default.
- W4319341258 cites W3129821771 @default.
- W4319341258 cites W3137108207 @default.
- W4319341258 cites W3137391848 @default.
- W4319341258 cites W3138613518 @default.
- W4319341258 cites W3156388316 @default.
- W4319341258 cites W3200713759 @default.
- W4319341258 cites W3212754704 @default.
- W4319341258 cites W4211067786 @default.
- W4319341258 cites W4225005516 @default.
- W4319341258 cites W4233138142 @default.
- W4319341258 cites W771030118 @default.
- W4319341258 doi "https://doi.org/10.1172/jci.insight.166688" @default.
- W4319341258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36752205" @default.
- W4319341258 hasPublicationYear "2023" @default.
- W4319341258 type Work @default.
- W4319341258 citedByCount "3" @default.
- W4319341258 countsByYear W43193412582023 @default.
- W4319341258 crossrefType "journal-article" @default.
- W4319341258 hasAuthorship W4319341258A5023872965 @default.
- W4319341258 hasAuthorship W4319341258A5031363665 @default.
- W4319341258 hasAuthorship W4319341258A5031574868 @default.
- W4319341258 hasAuthorship W4319341258A5032079976 @default.
- W4319341258 hasAuthorship W4319341258A5050038706 @default.
- W4319341258 hasAuthorship W4319341258A5055155526 @default.
- W4319341258 hasAuthorship W4319341258A5055740291 @default.
- W4319341258 hasAuthorship W4319341258A5056739139 @default.
- W4319341258 hasAuthorship W4319341258A5056937076 @default.
- W4319341258 hasAuthorship W4319341258A5071615222 @default.
- W4319341258 hasAuthorship W4319341258A5074669575 @default.
- W4319341258 hasAuthorship W4319341258A5077067783 @default.
- W4319341258 hasAuthorship W4319341258A5080870673 @default.
- W4319341258 hasAuthorship W4319341258A5089611506 @default.
- W4319341258 hasBestOaLocation W43193412581 @default.
- W4319341258 hasConcept C104317684 @default.
- W4319341258 hasConcept C105702510 @default.
- W4319341258 hasConcept C11960822 @default.
- W4319341258 hasConcept C126322002 @default.
- W4319341258 hasConcept C134018914 @default.