FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319348049> ?p ?o ?g. }

• W4319348049 abstract "Abstract Cochlear implant restores hearing loss through electrical stimulation of the hearing nerve from within the cochlea. Unfortunately, surgical implantation of this neuroprosthesis often traumatizes delicate intracochlear structures, resulting in loss of residual hearing and compromising hearing in noisy environments and appreciation of music. To avoid cochlear trauma, insertion techniques and devices have to be adjusted to the cochlear microanatomy. However, existing techniques were unable to achieve a representative visualization of the human cochlea: classical histology damages the tissues and lacks 3D perspective; standard microCT fails to resolve the cochlear soft tissues; and previously used X-ray contrast-enhancing staining agents are destructive. In this study, we overcame these limitations by performing contrast-enhanced microCT imaging (CECT) with a novel polyoxometalate staining agent Hf-WD POM. With Hf-WD POM-based CECT, we achieved nondestructive, high-resolution, simultaneous, 3D visualization of the mineralized and soft microstructures in fresh-frozen human cochleae. This enabled quantitative analysis of the true intracochlear dimensions and led to anatomical discoveries, concerning surgically-relevant microstructures: the round window membrane, the Rosenthal’s canal and the secondary spiral lamina. Furthermore, we demonstrated that Hf-WD POM-based CECT enables quantitative assessment of these structures as well as their trauma." @default.
• W4319348049 created "2023-02-08" @default.
• W4319348049 creator A5002172692 @default.
• W4319348049 creator A5018631910 @default.
• W4319348049 creator A5021753781 @default.
• W4319348049 creator A5028170041 @default.
• W4319348049 creator A5058825456 @default.
• W4319348049 creator A5069178600 @default.
• W4319348049 creator A5070263200 @default.
• W4319348049 date "2023-02-07" @default.
• W4319348049 modified "2023-10-18" @default.
• W4319348049 title "Human cochlear microstructures at risk of electrode insertion trauma, elucidated in 3D with contrast-enhanced microCT" @default.
• W4319348049 cites W1574853329 @default.
• W4319348049 cites W1575834180 @default.
• W4319348049 cites W1936713698 @default.
• W4319348049 cites W1966081178 @default.
• W4319348049 cites W1970957245 @default.
• W4319348049 cites W1972649658 @default.
• W4319348049 cites W1974083224 @default.
• W4319348049 cites W1975147424 @default.
• W4319348049 cites W1978313495 @default.
• W4319348049 cites W1987080528 @default.
• W4319348049 cites W1995028227 @default.
• W4319348049 cites W2006872913 @default.
• W4319348049 cites W2007170729 @default.
• W4319348049 cites W2013304858 @default.
• W4319348049 cites W2021705972 @default.
• W4319348049 cites W2024487015 @default.
• W4319348049 cites W2027398061 @default.
• W4319348049 cites W2030757467 @default.
• W4319348049 cites W2038385925 @default.
• W4319348049 cites W2043468014 @default.
• W4319348049 cites W2044534939 @default.
• W4319348049 cites W2052119774 @default.
• W4319348049 cites W2060520825 @default.
• W4319348049 cites W2071149137 @default.
• W4319348049 cites W2073182160 @default.
• W4319348049 cites W2075986568 @default.
• W4319348049 cites W2076930425 @default.
• W4319348049 cites W2078339205 @default.
• W4319348049 cites W2081988210 @default.
• W4319348049 cites W2085088057 @default.
• W4319348049 cites W2089962112 @default.
• W4319348049 cites W2091483266 @default.
• W4319348049 cites W2095273280 @default.
• W4319348049 cites W2103349714 @default.
• W4319348049 cites W2116831588 @default.
• W4319348049 cites W2117649515 @default.
• W4319348049 cites W2135148152 @default.
• W4319348049 cites W2145719251 @default.
• W4319348049 cites W2154129661 @default.
• W4319348049 cites W2157812230 @default.
• W4319348049 cites W2225859319 @default.
• W4319348049 cites W2288550575 @default.
• W4319348049 cites W2313844013 @default.
• W4319348049 cites W2321740284 @default.
• W4319348049 cites W2471308520 @default.
• W4319348049 cites W2491780613 @default.
• W4319348049 cites W2520526731 @default.
• W4319348049 cites W2560816968 @default.
• W4319348049 cites W2567701755 @default.
• W4319348049 cites W2606653758 @default.
• W4319348049 cites W2618602101 @default.
• W4319348049 cites W2653662022 @default.
• W4319348049 cites W2754654943 @default.
• W4319348049 cites W2769807891 @default.
• W4319348049 cites W2780806842 @default.
• W4319348049 cites W2788032313 @default.
• W4319348049 cites W2789474493 @default.
• W4319348049 cites W2792599188 @default.
• W4319348049 cites W2792865263 @default.
• W4319348049 cites W2800789123 @default.
• W4319348049 cites W2807658854 @default.
• W4319348049 cites W2810205352 @default.
• W4319348049 cites W2885273358 @default.
• W4319348049 cites W2890214648 @default.
• W4319348049 cites W2911779531 @default.
• W4319348049 cites W2911857607 @default.
• W4319348049 cites W2937757274 @default.
• W4319348049 cites W2951932099 @default.
• W4319348049 cites W2954781037 @default.
• W4319348049 cites W2969698119 @default.
• W4319348049 cites W2976955340 @default.
• W4319348049 cites W2978572687 @default.
• W4319348049 cites W2983389478 @default.
• W4319348049 cites W2991561773 @default.
• W4319348049 cites W2994968700 @default.
• W4319348049 cites W3002556582 @default.
• W4319348049 cites W3008931792 @default.
• W4319348049 cites W3048827118 @default.
• W4319348049 cites W3112991670 @default.
• W4319348049 cites W3116198284 @default.
• W4319348049 cites W3118577024 @default.
• W4319348049 cites W3135244458 @default.
• W4319348049 cites W3164498845 @default.
• W4319348049 cites W3201925913 @default.
• W4319348049 cites W4200109589 @default.
• W4319348049 cites W4200545795 @default.
• W4319348049 cites W4210968408 @default.
• W4319348049 cites W4283399513 @default.

• next