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- W4319432335 abstract "Abstract Costimulatory CD40 plays an essential role in autoimmune disease models including experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS). However, the mechanism underlying CD40 function are not well defined in these processes. Conditional knockout of CD40 on either dendritic cells (DCs) or B cells led to profoundly reduced severity of EAE induced by recombinant human MOG (rhMOG). CD40 expression on DCs, but not on B cells, was required for priming of pathogenic T helper (Th) cells in peripheral draining lymph nodes and for appearance of these pathogenic T cells in the CNS. In marked contrast, CD40 on B cells, but not on DCs, was essential for class-switched MOG-specific antibody production. The distinct function of CD40 on B cells and DC was confirmed by the ability of transferred MOG-immune serum to restore sensitivity to EAE in mice lacking CD40 on B cells but not in mice lacking CD40 on DC. Thus, CD40 expressed on B cells and on DC provides distinct and complementary pathways essential for EAE pathogenesis, providing multiple targets for intervention in EAE, and potentially for MS and other autoimmune diseases." @default.
- W4319432335 created "2023-02-09" @default.
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- W4319432335 date "2021-05-01" @default.
- W4319432335 modified "2023-09-28" @default.
- W4319432335 title "CD40 on B cells and on dendritic cells mediates experimental autoimmune encephalomyelitis pathogenesis through distinct and complementary mechanisms" @default.
- W4319432335 doi "https://doi.org/10.4049/jimmunol.206.supp.18.09" @default.
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