Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319433899> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4319433899 endingPage "16.26" @default.
- W4319433899 startingPage "16.26" @default.
- W4319433899 abstract "Abstract CD4+ T cells are crucial to control pulmonary tuberculosis, but also favor uncontrolled inflammation in severe disease. Effective CD4+ T cell response to tuberculosis is related to tissue location: Lung-resident CD4+ T cells display higher effector function in comparison to circulating cells. Among the factors favoring T cell residency in non-lymphoid tissues, extracellular ATP sensing via P2RX7 is crucial for the generation of virus-specific resident memory CD8+ T cells. Yet, its role in CD4+ T cell non-lymphoid tissue residency has not been defined. Moreover, mycobacterial infection induces high extracellular ATP levels due to lung tissue damage, which is increased in response to hypervirulent strains. Here, we used P2rx7 ablation models to test the role of P2RX7 in CD4+T cell function in tuberculosis. In response to the hypervirulent Mycobacterium bovis MP287/03 strain, lung-resident WT CD4+ T cells express higher P2RX7 levels compared to circulating CD4+ T cells. Compared to WT mice, P2RX7-deficient (P2rx7−/−) mice display reduced numbers of antigen-specific (I-AbESAT-64-17) and IFN-γ-producing CD4+ T cells in the lung parenchyma. Using cell adoptive transfers, while recipient CD4-deficient mice transferred with CD4+ WT T cells are protected, mice that received CD4+P2rx7−/− T cells develop severe tuberculosis. Mechanistically, CD4+P2rx7−/− T cells have poorer accumulation and IFN-γ production in the lung parenchyma; moreover, they show reduced proliferation in situ. This defect in proliferation is exclusively observed in the lung, with no differences observed in draining lymph nodes. Together, our results show that P2RX7 promote the accumulation of protective CD4+ T cells in the lung during severe tuberculosis." @default.
- W4319433899 created "2023-02-09" @default.
- W4319433899 creator A5008883193 @default.
- W4319433899 creator A5019072406 @default.
- W4319433899 creator A5021005808 @default.
- W4319433899 creator A5028258162 @default.
- W4319433899 creator A5063205833 @default.
- W4319433899 creator A5065177725 @default.
- W4319433899 creator A5068571366 @default.
- W4319433899 creator A5068888456 @default.
- W4319433899 creator A5074310174 @default.
- W4319433899 creator A5076903241 @default.
- W4319433899 date "2021-05-01" @default.
- W4319433899 modified "2023-09-27" @default.
- W4319433899 title "The purinergic receptor P2RX7 promotes the accumulation of effector CD4+ T cells in the lung parenchyma during hypervirulent mycobacterial infection" @default.
- W4319433899 doi "https://doi.org/10.4049/jimmunol.206.supp.16.26" @default.
- W4319433899 hasPublicationYear "2021" @default.
- W4319433899 type Work @default.
- W4319433899 citedByCount "0" @default.
- W4319433899 crossrefType "journal-article" @default.
- W4319433899 hasAuthorship W4319433899A5008883193 @default.
- W4319433899 hasAuthorship W4319433899A5019072406 @default.
- W4319433899 hasAuthorship W4319433899A5021005808 @default.
- W4319433899 hasAuthorship W4319433899A5028258162 @default.
- W4319433899 hasAuthorship W4319433899A5063205833 @default.
- W4319433899 hasAuthorship W4319433899A5065177725 @default.
- W4319433899 hasAuthorship W4319433899A5068571366 @default.
- W4319433899 hasAuthorship W4319433899A5068888456 @default.
- W4319433899 hasAuthorship W4319433899A5074310174 @default.
- W4319433899 hasAuthorship W4319433899A5076903241 @default.
- W4319433899 hasConcept C154317977 @default.
- W4319433899 hasConcept C167672396 @default.
- W4319433899 hasConcept C196822366 @default.
- W4319433899 hasConcept C202751555 @default.
- W4319433899 hasConcept C203014093 @default.
- W4319433899 hasConcept C2776090121 @default.
- W4319433899 hasConcept C28406088 @default.
- W4319433899 hasConcept C51785407 @default.
- W4319433899 hasConcept C55493867 @default.
- W4319433899 hasConcept C57306754 @default.
- W4319433899 hasConcept C59822182 @default.
- W4319433899 hasConcept C86803240 @default.
- W4319433899 hasConcept C8891405 @default.
- W4319433899 hasConcept C90375314 @default.
- W4319433899 hasConcept C95444343 @default.
- W4319433899 hasConceptScore W4319433899C154317977 @default.
- W4319433899 hasConceptScore W4319433899C167672396 @default.
- W4319433899 hasConceptScore W4319433899C196822366 @default.
- W4319433899 hasConceptScore W4319433899C202751555 @default.
- W4319433899 hasConceptScore W4319433899C203014093 @default.
- W4319433899 hasConceptScore W4319433899C2776090121 @default.
- W4319433899 hasConceptScore W4319433899C28406088 @default.
- W4319433899 hasConceptScore W4319433899C51785407 @default.
- W4319433899 hasConceptScore W4319433899C55493867 @default.
- W4319433899 hasConceptScore W4319433899C57306754 @default.
- W4319433899 hasConceptScore W4319433899C59822182 @default.
- W4319433899 hasConceptScore W4319433899C86803240 @default.
- W4319433899 hasConceptScore W4319433899C8891405 @default.
- W4319433899 hasConceptScore W4319433899C90375314 @default.
- W4319433899 hasConceptScore W4319433899C95444343 @default.
- W4319433899 hasIssue "1_Supplement" @default.
- W4319433899 hasLocation W43194338991 @default.
- W4319433899 hasOpenAccess W4319433899 @default.
- W4319433899 hasPrimaryLocation W43194338991 @default.
- W4319433899 hasRelatedWork W1488028176 @default.
- W4319433899 hasRelatedWork W1540340473 @default.
- W4319433899 hasRelatedWork W1621856421 @default.
- W4319433899 hasRelatedWork W2053568912 @default.
- W4319433899 hasRelatedWork W2055715607 @default.
- W4319433899 hasRelatedWork W2072008518 @default.
- W4319433899 hasRelatedWork W2159389701 @default.
- W4319433899 hasRelatedWork W2216689108 @default.
- W4319433899 hasRelatedWork W2789460834 @default.
- W4319433899 hasRelatedWork W4313404873 @default.
- W4319433899 hasVolume "206" @default.
- W4319433899 isParatext "false" @default.
- W4319433899 isRetracted "false" @default.
- W4319433899 workType "article" @default.