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- W4319436465 abstract "We propose a virtual clinical trial for assessing the safety and efficacy of closed-loop diabetes treatments prior to an actual clinical trial. Such virtual trials enable rapid and risk-free pretrial testing of algorithms, and they can be used to compare different treatment variations for large and diverse populations. The participants are represented by multiple mathematical models, consisting of stochastic differential equations, and we use Monte Carlo closed-loop simulations to compute detailed statistics of the closed-loop treatments. We implement the virtual clinical trial using high-performance software and hardware, and we present an example trial with two mathematical models of one million participants over 52 weeks (i.e., two million simulations), which can be completed in 2 h 9 min." @default.
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- W4319436465 date "2022-01-01" @default.
- W4319436465 modified "2023-10-16" @default.
- W4319436465 title "Large-scale Virtual Clinical Trials of Closed-loop Treatments for People with Type 1 Diabetes" @default.
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- W4319436465 doi "https://doi.org/10.1016/j.ifacol.2023.01.037" @default.
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