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• W4319438082 endingPage "1730" @default.
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• W4319438082 abstract "Abstract Neuroimaging studies implicate multiple cortical regions in reading ability/disability. However, the neural cell types integral to the reading process are unknown. To contribute to this gap in knowledge, we integrated genetic results from genome-wide association studies for word reading (n = 5054) with gene expression datasets from adult/fetal human brain. Linkage disequilibrium score regression (LDSC) suggested that variants associated with word reading were enriched in genes expressed in adult excitatory neurons, specifically layer 5 and 6 FEZF2 expressing neurons and intratelencephalic (IT) neurons, which express the marker genes LINC00507, THEMIS, or RORB. Inhibitory neurons (VIP, SST, and PVALB) were also found. This finding was interesting as neurometabolite studies previously implicated excitatory-inhibitory imbalances in the etiology of reading disabilities (RD). We also tested traits that shared genetic etiology with word reading (previously determined by polygenic risk scores): attention-deficit/hyperactivity disorder (ADHD), educational attainment, and cognitive ability. For ADHD, we identified enrichment in L4 IT adult excitatory neurons. For educational attainment and cognitive ability, we confirmed previous studies identifying multiple subclasses of adult cortical excitatory and inhibitory neurons, as well as astrocytes and oligodendrocytes. For educational attainment and cognitive ability, we also identified enrichment in multiple fetal cortical excitatory and inhibitory neurons, intermediate progenitor cells, and radial glial cells. In summary, this study supports a role of excitatory and inhibitory neurons in reading and excitatory neurons in ADHD and contributes new information on fetal cell types enriched in educational attainment and cognitive ability, thereby improving our understanding of the neurobiological basis of reading/correlated traits." @default.
• W4319438082 created "2023-02-09" @default.
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• W4319438082 date "2023-02-07" @default.
• W4319438082 modified "2023-10-15" @default.
• W4319438082 title "Identification of brain cell types underlying genetic association with word reading and correlated traits" @default.
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• W4319438082 cites W1866095408 @default.
• W4319438082 cites W1982236792 @default.
• W4319438082 cites W1989466553 @default.
• W4319438082 cites W2005900392 @default.
• W4319438082 cites W2059606936 @default.
• W4319438082 cites W2059742736 @default.
• W4319438082 cites W2061413929 @default.
• W4319438082 cites W2062561058 @default.
• W4319438082 cites W2065059368 @default.
• W4319438082 cites W2069724292 @default.
• W4319438082 cites W2070021921 @default.
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• W4319438082 cites W2081485012 @default.
• W4319438082 cites W2091035921 @default.
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• W4319438082 cites W2095796823 @default.
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• W4319438082 cites W2195783463 @default.
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• W4319438082 cites W2809193491 @default.
• W4319438082 cites W2883573930 @default.
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• W4319438082 doi "https://doi.org/10.1038/s41380-023-01970-y" @default.
• W4319438082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36750735" @default.
• W4319438082 hasPublicationYear "2023" @default.
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