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• W4319446423 abstract "Probiotics play a vital role in decreasing glycemic and hyperlipidemic state by decreasing oxidative stress in type 2 diabetes mellitus (T2DM) patients. Several in-vivo studies reported the role of probiotics in alleviating glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels but with conflicting results. Therefore, current meta-analysis study was designed to determine the possible role of probiotics in altering the status of T2DM. Meta-analysis was conducted to assess the possible relationship between probiotic and reduced levels of FBG, HbA1c and Homeostasis model of assessment of insulin resistance (HOMA-IR) in total 1040, 553 and 495 subjects respectively. Nineteen studies were found eligible for the meta-analysis according to inclusion and exclusion criteria as per international norms. Statistical analysis was done using Review Manager 5.4 and Comprehensive meta- analysis 3.0. Significant difference was observed between placebo and probiotic fed group was assessed using pooled mean difference. Q-test (I2) was used to test the heterogeneity among studies and publication bias was analyzed using funnel plot. HbA1c, FBG and HOMA-IR levels reduced significantly in probiotic fed group of T2DM patients. However, decrease in HbA1c levels was more significant as compared with FBG and HOMA-IR levels, thereby suggesting that long term use of probiotic results in alleviating T2DM. Meta-analysis studies suggest that probiotics might play an important role in improving glycemic index of T2DM patients." @default.
• W4319446423 created "2023-02-09" @default.
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• W4319446423 date "2023-02-01" @default.
• W4319446423 modified "2023-09-23" @default.
• W4319446423 title "Impact of probiotics in alleviating type 2 diabetes risk in clinical trials: A meta-analysis study" @default.
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• W4319446423 doi "https://doi.org/10.1016/j.humgen.2023.201149" @default.
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