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• W4319456249 abstract "Abstract Background To explore the correlation of tumor necrosis factor-α-induced protein 8-like protein 3 (TIPE3) expressions in colorectal cancer (CRC) with tumor-immune infiltration and patient prognosis. Methods Formalin-fixed paraffin-embedded tumor samples from CRC patients ( n = 110) were used in this study. Immunohistochemistry staining of TIPE3 and three prognostic immune biomarkers (CD8, CD20, and CD66b) was conducted in the tumor tissues and adjacent normal tissues. A Cox regression analysis of univariate and multivariate variables was performed to assess the correlation between TIPE3 and patient prognosis. Result We found that TIPE3 was mainly expressed in the cytoplasm, with a small amount in the nucleus. The expression of TIPE3 in tumor tissues is significantly higher than in adjacent normal tissues, and it is significantly correlated with the survival rate of patients in tumor tissues ( p = 0.0038) and adjacent normal tissues ( p <0.0001). Patients with a high TIPE3 expression had a lower survival rate, while patients with a low TIPE3 expression had a higher survival rate. Univariate regression analysis showed that the TIPE3 expression in tumor tissues ( p = 0.007), the TIPE3 expression in adjacent normal tissues ( p <0.001), the number of CD8+ T cells in tumor tissues ( p = 0.020), the number of CD20+ B cells in tumor tissues ( p = 0.023), the number of CD20+ B cells in adjacent normal tissues ( p = 0.023), the number of CD66b+ neutrophils in tumor tissues ( p = 0.005), the number of CD66b+ neutrophils in adjacent normal tissues ( p <0.001), lymphatic metastasis ( p = 0.010), TNM stage ( p = 0.013), and tumor grade ( p = 0.027) were significantly correlated with overall survival (OS). These prognostic factors were then subjected to multivariate regression analysis, and the results showed that the expression of TIPE3, the number of CD8+ T cells, and the number of CD66b+ neutrophils were prognostic factors affecting the OS rate of CRC patients. Conclusion We found that the TIPE3 protein is upregulated in CRC cancer tissues and is correlated with survival rate." @default.
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• W4319456249 date "2023-02-08" @default.
• W4319456249 modified "2023-10-14" @default.
• W4319456249 title "Tumor necrosis factor-α-inducible protein 8-like protein 3 (TIPE3): a novel prognostic factor in colorectal cancer" @default.
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• W4319456249 doi "https://doi.org/10.1186/s12885-023-10590-2" @default.
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