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- W4319457420 abstract "Neutrophil extracellular traps (NETs) are detected in both COVID-19 and autoimmune disorders. Molecular mimicry between NETs-related proteins and SARS-CoV-2 proteins may be the mechanism that can lead to an autoimmune response. Accordingly, similar sequences were searched with blastp, between SARS-CoV-2 proteins and 148 proteins that were reported in the NETs composition induced in neutrophils of supernatants from patients with systemic lupus erythematosus and lupus nephritis. Query-subject epitope pairs with strong-binding affinities to 12 HLA supertype representative alleles were predicted for the aligned sequences with at least 50% identities. According to the prediction results, all HLA alleles under study have affinities to the similar SARS-CoV-2 and NETs' proteins. These affinities can bring molecular mimicry-based autoimmunity risk with NETs-pathology, in susceptible individuals, upon infection with SARS-CoV-2. However, HLA-A∗01:01 carriers can be at a higher risk due to the association of this allele with the highest number of NETs-related human proteins, and similar (unique) query-subject epitope pairs of those proteins and SARS-CoV-2. Additionally, HLA-A∗02:01 carriers may specifically be prone to higher risk than expected, if infected with SARS-CoV-2. Furthermore, HLA-A∗24:02 was predicted to bind strongly to an elevated number of unique SARS-CoV-2 subject sequences while the number of both associated human proteins, and unique queries of those, are rather low. It may be indicative of a pertaining pathology despite viral evolution." @default.
- W4319457420 created "2023-02-09" @default.
- W4319457420 creator A5070840190 @default.
- W4319457420 creator A5074738902 @default.
- W4319457420 date "2023-01-01" @default.
- W4319457420 modified "2023-09-27" @default.
- W4319457420 title "In silico study of molecular mimicry between SARS-CoV-2 and neutrophil extracellular traps composition in granulocyte-rich supernatants of patients with systemic lupus erythematosus and lupus nephritis" @default.
- W4319457420 cites W1675847437 @default.
- W4319457420 cites W1985551427 @default.
- W4319457420 cites W1989969147 @default.
- W4319457420 cites W2000305183 @default.
- W4319457420 cites W2008943339 @default.
- W4319457420 cites W2012625502 @default.
- W4319457420 cites W2018860370 @default.
- W4319457420 cites W2030193400 @default.
- W4319457420 cites W2036574393 @default.
- W4319457420 cites W2052250375 @default.
- W4319457420 cites W2053528586 @default.
- W4319457420 cites W2055465622 @default.
- W4319457420 cites W2080338710 @default.
- W4319457420 cites W2086514355 @default.
- W4319457420 cites W2110694683 @default.
- W4319457420 cites W2122691845 @default.
- W4319457420 cites W2125732073 @default.
- W4319457420 cites W2136750065 @default.
- W4319457420 cites W2142269152 @default.
- W4319457420 cites W2146099850 @default.
- W4319457420 cites W2158714788 @default.
- W4319457420 cites W2159675211 @default.
- W4319457420 cites W2160534673 @default.
- W4319457420 cites W2160563582 @default.
- W4319457420 cites W2162439245 @default.
- W4319457420 cites W2170637386 @default.
- W4319457420 cites W2271914738 @default.
- W4319457420 cites W2474747771 @default.
- W4319457420 cites W2558586574 @default.
- W4319457420 cites W2605491526 @default.
- W4319457420 cites W2608171249 @default.
- W4319457420 cites W2728694650 @default.
- W4319457420 cites W2743893844 @default.
- W4319457420 cites W2747699571 @default.
- W4319457420 cites W2749840526 @default.
- W4319457420 cites W2783102765 @default.
- W4319457420 cites W2889397971 @default.
- W4319457420 cites W2946955824 @default.
- W4319457420 cites W2953065444 @default.
- W4319457420 cites W2954133571 @default.
- W4319457420 cites W2996169473 @default.
- W4319457420 cites W3015050005 @default.
- W4319457420 cites W3015344553 @default.
- W4319457420 cites W3016299116 @default.
- W4319457420 cites W3017020108 @default.
- W4319457420 cites W3017304088 @default.
- W4319457420 cites W3021266070 @default.
- W4319457420 cites W3021816206 @default.
- W4319457420 cites W3024570138 @default.
- W4319457420 cites W3024907874 @default.
- W4319457420 cites W3028098130 @default.
- W4319457420 cites W3030833760 @default.
- W4319457420 cites W3034241701 @default.
- W4319457420 cites W3035462977 @default.
- W4319457420 cites W3035618713 @default.
- W4319457420 cites W3037361899 @default.
- W4319457420 cites W3038009121 @default.
- W4319457420 cites W3041494167 @default.
- W4319457420 cites W3042539143 @default.
- W4319457420 cites W3042587425 @default.
- W4319457420 cites W3042676445 @default.
- W4319457420 cites W3043831218 @default.
- W4319457420 cites W3045894551 @default.
- W4319457420 cites W3045933491 @default.
- W4319457420 cites W3046231656 @default.
- W4319457420 cites W3049048202 @default.
- W4319457420 cites W3049325061 @default.
- W4319457420 cites W3057236025 @default.
- W4319457420 cites W3081499927 @default.
- W4319457420 cites W3082451088 @default.
- W4319457420 cites W3085247423 @default.
- W4319457420 cites W3087116551 @default.
- W4319457420 cites W3088060702 @default.
- W4319457420 cites W3088256443 @default.
- W4319457420 cites W3091861357 @default.
- W4319457420 cites W3092605738 @default.
- W4319457420 cites W3093403361 @default.
- W4319457420 cites W3094032395 @default.
- W4319457420 cites W3095535158 @default.
- W4319457420 cites W3096975836 @default.
- W4319457420 cites W3109446887 @default.
- W4319457420 cites W3112688552 @default.
- W4319457420 cites W3112963986 @default.
- W4319457420 cites W3120046290 @default.
- W4319457420 cites W3120750707 @default.
- W4319457420 cites W3125872925 @default.
- W4319457420 cites W3126541761 @default.
- W4319457420 cites W3129564206 @default.
- W4319457420 cites W3132728920 @default.
- W4319457420 cites W3134128337 @default.
- W4319457420 cites W3135408003 @default.