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• W4319460048 abstract "ABSTRACT The Drosophila tko 25t point mutation in the gene encoding mitoribosomal protein S12 produces a complex phenotype of multiple respiratory chain deficiency, developmental delay, bang-sensitivity, impaired hearing, sugar and antibiotic sensitivity and impaired male courtship. Its phenotypic severity was previously shown to be alleviated by inbreeding, and to vary with mitochondrial genetic background. Here we show similarly profound effects conferred by nuclear genetic background. We backcrossed tko 25t into each of two standard nuclear backgrounds, Oregon R and w 1118 , the latter used as recipient line in many transgenic applications requiring selection for the white minigene marker. In the w 1118 background, tko 25t flies showed a moderate developmental delay and modest bang-sensitivity. In the Oregon R background, males showed longer developmental delay and more severe bang-sensitivity, and we were initially unable to produce homozygous tko 25t females in sufficient numbers to conduct a meaningful analysis. When maintained as a balanced stock over 2 years, tko 25t flies in the Oregon R background showed clear phenotypic improvement though were still more severely affected than in the w 1118 background. Phenotypic severity did not correlate with the expression level of the tko gene. Analysis of tko25t hybrids between the two backgrounds indicated that phenotypic severity was conferred by autosomal, X-chromosomal and parent-of-origin dependent determinants. Although some of these effects may be tko 25t -specific, we recommend that, in order to minimize genetic drift and confounding background effects, the genetic background of non-lethal mutants should be controlled by regular backcrossing, even if stocks are usually maintained over a balancer chromosome." @default.
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• W4319460048 date "2023-02-08" @default.
• W4319460048 modified "2023-10-17" @default.
• W4319460048 title "Nuclear genetic background influences the phenotype of the<i>Drosophila tko^25t</i>mitochondrial protein-synthesis mutant" @default.
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• W4319460048 doi "https://doi.org/10.1101/2023.02.06.527322" @default.
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