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- W4319460068 endingPage "102989" @default.
- W4319460068 startingPage "102989" @default.
- W4319460068 abstract "The human gastrointestinal (GI) tract harbors diverse microbial communities collectively known as the gut microbiota that exert a profound impact on human health and disease. The repartition and availability of sialic acid derivatives in the gut have a significant impact on the modulation of gut microbes and host susceptibility to infection and inflammation. Although N-acetylneuraminic acid (Neu5Ac) is the main form of sialic acids in humans, the sialic acid family regroups more than 50 structurally and chemically distinct modified derivatives. In the GI tract, sialic acids are found in the terminal location of mucin glycan chains constituting the mucus layer and also come from human milk oligosaccharides in the infant gut or from meat-based foods in adults. The repartition of sialic acid in the GI tract influences the gut microbiota composition and pathogen colonization. In this review, we provide an update on the mechanisms underpinning sialic acid utilization by gut microbes, focusing on sialidases, transporters, and metabolic enzymes." @default.
- W4319460068 created "2023-02-09" @default.
- W4319460068 creator A5021307435 @default.
- W4319460068 creator A5026456663 @default.
- W4319460068 creator A5047341129 @default.
- W4319460068 creator A5051713483 @default.
- W4319460068 creator A5068753249 @default.
- W4319460068 date "2023-03-01" @default.
- W4319460068 modified "2023-10-10" @default.
- W4319460068 title "Biochemical and structural basis of sialic acid utilization by gut microbes" @default.
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