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- W4319460647 abstract "A series of twenty alkyl derivatives (2-21) of 4-amino benzoic acid (1, PABA) have been prepared using potassium carbonate and opportune alkylating agents under simple and mild reaction conditions. Compounds (16-21) are reported for the first time. Electron impact mass spectrometry (EIMS), Fourier transform infrared (FTIR) and Proton nuclear magnetic resonance (1H-NMR) spectroscopic techniques were adopted for the characterization of these analogues. In the present study, the cytotoxic screening of sixteen compounds (3, 5-11, 13 and 15-21) was also achieved against lung (NCI-H460) and oral squamous carcinoma (CAL-27) cell lines. Compound 20 has shown magnificent inhibitory properties against NCI-H460 cell line (IC50 15.59 and 20.04 µM, respectively) at a lower dose than that of the control (cisplatin; IC50 21.00 µM). One-way analysis of variance (ANOVA), t-test and Pearson correlation coefficient (PCC) have been performed to determine the reliability of current data through statistical package for the social sciences (SPSS)." @default.
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- W4319460647 date "2023-02-08" @default.
- W4319460647 modified "2023-10-17" @default.
- W4319460647 title "An efficient synthesis of <i>O-</i> and <i>N-</i> alkyl derivatives of 4-aminobenzoic acid and evaluation of their anticancer properties" @default.
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- W4319460647 doi "https://doi.org/10.1080/14786419.2023.2169916" @default.
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