Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319461005> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4319461005 abstract "Background Hypertension is associated with gut dysbiosis, altered intestinal immunity, and gut pathology in animal models and humans. Although these findings have implicated impaired interactions between gut and gut microbiota in hypertension, little is known about the specific functional gut microbes that interact with intestinal mucosa. Methods and Results To identify these microbes, we sorted Immunoglobin A (IgA)-coated (IgA+) and IgA-noncoated (IgA-) bacteria using a combination of magnetic-activated cell sorting and fluorescence-activated cell sorting, and subsequently performed 16 S rRNA gene sequencing (IgA-SEQ) to determine the microbial composition of IgA+ and IgA- fractions in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats. We observed a significant decrease in IgA+ bacteria in SHR compared with Wistar Kyoto and a distinct composition of IgA+ and IgA- bacteria between Wistar Kyoto and SHR, showing more IgA-bound Proteobacteria, Bacteroidetes and Actinobacteria but less of Firmicutes in SHR at the phylum level. We further identified enriched IgA-coated Romboutsia, Turicibacter, Ileibacterium, and Dubosiella in SHR that were negatively correlated with the various pathways including antigen presentation, immune response, cell junction organization, epithelium development, and defense response to virus. Conclusions We demonstrate new IgA-coated bacteria that participate in host-microbiota communication in hypertension, suggesting promising therapeutic interventions targeting these bacteria for hypertension management." @default.
- W4319461005 created "2023-02-09" @default.
- W4319461005 creator A5012677271 @default.
- W4319461005 creator A5014934001 @default.
- W4319461005 creator A5032815142 @default.
- W4319461005 creator A5071839746 @default.
- W4319461005 creator A5073095319 @default.
- W4319461005 creator A5084059173 @default.
- W4319461005 date "2023-02-21" @default.
- W4319461005 modified "2023-10-14" @default.
- W4319461005 title "Host‐Microbiota Communication in Spontaneously Hypertensive Rats Generates Unique IgA‐Coated Gut Microbes" @default.
- W4319461005 cites W1979217507 @default.
- W4319461005 cites W2102747115 @default.
- W4319461005 cites W2136344314 @default.
- W4319461005 cites W2543448041 @default.
- W4319461005 cites W2759933576 @default.
- W4319461005 cites W2910299146 @default.
- W4319461005 cites W2937033043 @default.
- W4319461005 cites W2997928231 @default.
- W4319461005 cites W3001680293 @default.
- W4319461005 cites W3114167013 @default.
- W4319461005 cites W3173003804 @default.
- W4319461005 cites W4210651821 @default.
- W4319461005 cites W4211133389 @default.
- W4319461005 cites W4280654274 @default.
- W4319461005 cites W4291019371 @default.
- W4319461005 doi "https://doi.org/10.1161/jaha.122.027918" @default.
- W4319461005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36752270" @default.
- W4319461005 hasPublicationYear "2023" @default.
- W4319461005 type Work @default.
- W4319461005 citedByCount "1" @default.
- W4319461005 countsByYear W43194610052023 @default.
- W4319461005 crossrefType "journal-article" @default.
- W4319461005 hasAuthorship W4319461005A5012677271 @default.
- W4319461005 hasAuthorship W4319461005A5014934001 @default.
- W4319461005 hasAuthorship W4319461005A5032815142 @default.
- W4319461005 hasAuthorship W4319461005A5071839746 @default.
- W4319461005 hasAuthorship W4319461005A5073095319 @default.
- W4319461005 hasAuthorship W4319461005A5084059173 @default.
- W4319461005 hasBestOaLocation W43194610051 @default.
- W4319461005 hasConcept C143121216 @default.
- W4319461005 hasConcept C203014093 @default.
- W4319461005 hasConcept C2777165150 @default.
- W4319461005 hasConcept C2777385719 @default.
- W4319461005 hasConcept C2777695942 @default.
- W4319461005 hasConcept C2779102806 @default.
- W4319461005 hasConcept C2779676784 @default.
- W4319461005 hasConcept C2780898057 @default.
- W4319461005 hasConcept C42062724 @default.
- W4319461005 hasConcept C523546767 @default.
- W4319461005 hasConcept C539455810 @default.
- W4319461005 hasConcept C54355233 @default.
- W4319461005 hasConcept C71924100 @default.
- W4319461005 hasConcept C86803240 @default.
- W4319461005 hasConcept C8891405 @default.
- W4319461005 hasConcept C89423630 @default.
- W4319461005 hasConceptScore W4319461005C143121216 @default.
- W4319461005 hasConceptScore W4319461005C203014093 @default.
- W4319461005 hasConceptScore W4319461005C2777165150 @default.
- W4319461005 hasConceptScore W4319461005C2777385719 @default.
- W4319461005 hasConceptScore W4319461005C2777695942 @default.
- W4319461005 hasConceptScore W4319461005C2779102806 @default.
- W4319461005 hasConceptScore W4319461005C2779676784 @default.
- W4319461005 hasConceptScore W4319461005C2780898057 @default.
- W4319461005 hasConceptScore W4319461005C42062724 @default.
- W4319461005 hasConceptScore W4319461005C523546767 @default.
- W4319461005 hasConceptScore W4319461005C539455810 @default.
- W4319461005 hasConceptScore W4319461005C54355233 @default.
- W4319461005 hasConceptScore W4319461005C71924100 @default.
- W4319461005 hasConceptScore W4319461005C86803240 @default.
- W4319461005 hasConceptScore W4319461005C8891405 @default.
- W4319461005 hasConceptScore W4319461005C89423630 @default.
- W4319461005 hasIssue "4" @default.
- W4319461005 hasLocation W43194610051 @default.
- W4319461005 hasLocation W43194610052 @default.
- W4319461005 hasLocation W43194610053 @default.
- W4319461005 hasOpenAccess W4319461005 @default.
- W4319461005 hasPrimaryLocation W43194610051 @default.
- W4319461005 hasRelatedWork W2467184611 @default.
- W4319461005 hasRelatedWork W2883768677 @default.
- W4319461005 hasRelatedWork W2905695710 @default.
- W4319461005 hasRelatedWork W2991043099 @default.
- W4319461005 hasRelatedWork W3016396428 @default.
- W4319461005 hasRelatedWork W3091889127 @default.
- W4319461005 hasRelatedWork W3136308305 @default.
- W4319461005 hasRelatedWork W3201941357 @default.
- W4319461005 hasRelatedWork W4310598025 @default.
- W4319461005 hasRelatedWork W4362661934 @default.
- W4319461005 hasVolume "12" @default.
- W4319461005 isParatext "false" @default.
- W4319461005 isRetracted "false" @default.
- W4319461005 workType "article" @default.