Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319461207> ?p ?o ?g. }
- W4319461207 endingPage "e0278755" @default.
- W4319461207 startingPage "e0278755" @default.
- W4319461207 abstract "Elucidation of structure and dynamics of alternative higher-order structures of DNA such as in branched form could be targeted for therapeutics designing. Herein, we are reporting the intrinsically dynamic and folds transitions of an unusual DNA junction with sequence d(CGGCGGCCGC)4 which self-assembles into a four-way DNA junction form with sticky ends using long interval molecular simulations under various artificial physiological conditions. The original crystal structure coordinates (PDB ID: 3Q5C) for the selected DNA junction was considered for a total of 1.1 μs molecular dynamics simulation interval, including different temperature and pH, under OPLS-2005 force field using DESMOND suite. Following, post-dynamics structure parameters for the DNA junction were calculated and analyzed by comparison to the crystal structure. We show here that the self-assembly dynamics of DNA junction is mitigated by the temperature and pH sensitivities, and discloses peculiar structural properties as function of time. From this study it can be concluded on account of temperature sensitive and pH dependent behaviours, DNA junction periodic arrangements can willingly be synthesized and redeveloped for multiple uses like genetic biomarkers, DNA biosensor, DNA nanotechnology, DNA Zipper, etc. Furthermore, the pH dis-regulation behaviour may be used to trigger the functionality of DNA made drug-releasing nanomachines." @default.
- W4319461207 created "2023-02-09" @default.
- W4319461207 creator A5010519713 @default.
- W4319461207 creator A5025068778 @default.
- W4319461207 creator A5027500407 @default.
- W4319461207 creator A5040576910 @default.
- W4319461207 creator A5058026637 @default.
- W4319461207 creator A5077040877 @default.
- W4319461207 creator A5079725231 @default.
- W4319461207 creator A5091838258 @default.
- W4319461207 date "2023-02-08" @default.
- W4319461207 modified "2023-09-30" @default.
- W4319461207 title "Understanding the self-assembly dynamics of A/T absent ‘four-way DNA junctions with sticky ends’ at altered physiological conditions through molecular dynamics simulations" @default.
- W4319461207 cites W1967548201 @default.
- W4319461207 cites W1974231617 @default.
- W4319461207 cites W1983874017 @default.
- W4319461207 cites W1988875152 @default.
- W4319461207 cites W1999411237 @default.
- W4319461207 cites W2001774624 @default.
- W4319461207 cites W2014508207 @default.
- W4319461207 cites W2026635338 @default.
- W4319461207 cites W2028553114 @default.
- W4319461207 cites W2035687084 @default.
- W4319461207 cites W2039903085 @default.
- W4319461207 cites W2042924251 @default.
- W4319461207 cites W2051381895 @default.
- W4319461207 cites W2063750781 @default.
- W4319461207 cites W2064135136 @default.
- W4319461207 cites W2064371652 @default.
- W4319461207 cites W2068301995 @default.
- W4319461207 cites W2068703672 @default.
- W4319461207 cites W2077850544 @default.
- W4319461207 cites W2078085951 @default.
- W4319461207 cites W2090858729 @default.
- W4319461207 cites W2093221728 @default.
- W4319461207 cites W2094100416 @default.
- W4319461207 cites W2095145098 @default.
- W4319461207 cites W2103945336 @default.
- W4319461207 cites W2106140689 @default.
- W4319461207 cites W2121469408 @default.
- W4319461207 cites W2122247955 @default.
- W4319461207 cites W2125043638 @default.
- W4319461207 cites W2131470126 @default.
- W4319461207 cites W2132695846 @default.
- W4319461207 cites W2141877184 @default.
- W4319461207 cites W2144844133 @default.
- W4319461207 cites W2153228625 @default.
- W4319461207 cites W2163977585 @default.
- W4319461207 cites W2165165230 @default.
- W4319461207 cites W2165371679 @default.
- W4319461207 cites W2765570848 @default.
- W4319461207 cites W2911600946 @default.
- W4319461207 cites W2967354077 @default.
- W4319461207 cites W3043607926 @default.
- W4319461207 cites W3046468150 @default.
- W4319461207 cites W3093080782 @default.
- W4319461207 cites W4200439862 @default.
- W4319461207 cites W4281709308 @default.
- W4319461207 cites W4303449078 @default.
- W4319461207 cites W4307091397 @default.
- W4319461207 cites W979501463 @default.
- W4319461207 cites W2036603638 @default.
- W4319461207 cites W2046832198 @default.
- W4319461207 doi "https://doi.org/10.1371/journal.pone.0278755" @default.
- W4319461207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36753480" @default.
- W4319461207 hasPublicationYear "2023" @default.
- W4319461207 type Work @default.
- W4319461207 citedByCount "0" @default.
- W4319461207 crossrefType "journal-article" @default.
- W4319461207 hasAuthorship W4319461207A5010519713 @default.
- W4319461207 hasAuthorship W4319461207A5025068778 @default.
- W4319461207 hasAuthorship W4319461207A5027500407 @default.
- W4319461207 hasAuthorship W4319461207A5040576910 @default.
- W4319461207 hasAuthorship W4319461207A5058026637 @default.
- W4319461207 hasAuthorship W4319461207A5077040877 @default.
- W4319461207 hasAuthorship W4319461207A5079725231 @default.
- W4319461207 hasAuthorship W4319461207A5091838258 @default.
- W4319461207 hasBestOaLocation W43194612071 @default.
- W4319461207 hasConcept C121332964 @default.
- W4319461207 hasConcept C12554922 @default.
- W4319461207 hasConcept C145912823 @default.
- W4319461207 hasConcept C147597530 @default.
- W4319461207 hasConcept C159467904 @default.
- W4319461207 hasConcept C171250308 @default.
- W4319461207 hasConcept C185592680 @default.
- W4319461207 hasConcept C191961535 @default.
- W4319461207 hasConcept C192562407 @default.
- W4319461207 hasConcept C24890656 @default.
- W4319461207 hasConcept C552990157 @default.
- W4319461207 hasConcept C55493867 @default.
- W4319461207 hasConcept C59593255 @default.
- W4319461207 hasConcept C65556437 @default.
- W4319461207 hasConcept C8010536 @default.
- W4319461207 hasConcept C86803240 @default.
- W4319461207 hasConceptScore W4319461207C121332964 @default.
- W4319461207 hasConceptScore W4319461207C12554922 @default.
- W4319461207 hasConceptScore W4319461207C145912823 @default.
- W4319461207 hasConceptScore W4319461207C147597530 @default.