FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319461246> ?p ?o ?g. }

• W4319461246 endingPage "1334" @default.
• W4319461246 startingPage "1322" @default.
• W4319461246 abstract "Mitophagy is related to chondrocyte homeostasis and plays a key role in the progress of osteoarthritis (OA). Baicalin has a protective effect on OA chondrocytes, the aim of this study was to explore whether the effect of Baicalin on IL-1β-induced chondrocyte injury is related to the regulation of mitophagy. The expression of collagen II in chondrocytes was detected to identify chondrocytes. The effects of different concentrations of Baicalin (10, 20 and 40 μM), autophagy inhibitor (3-Methyladenine), autophagy activator (rapamycin) and Baicalin combined with PI3K agonist (740Y-P) on the viability (cell counting kit 8), apoptosis (flow cytometry), autophagy activation (Monodansylcadaverine staining) and mitochondrial membrane potential (JC-1 kit) of IL-1β-induced chondrocytes were evaluated. The co-localization of autophagosome and mitochondria was determined by immunofluorescence. Apoptosis-, autophagy-, PI3K/AKT/mTOR pathway- and mitophagy-related proteins were detected by western blot. Our result revealed that Baicalin and rapamycin facilitated cell viability, autophagy and mitophagy, elevated mitochondrial membrane potential and suppressed apoptosis of IL-1β-induced rat chondrocytes. In addition, Baicalin and rapamycin upregulated the levels of Bcl-2, Beclin 1, LC3-II/LC3-I, p-Drp1, PINK1 and Parkin as well as downregulated the levels of Bax, cleaved caspase-3, P62, p-PI3K/PI3K, p-mTOR/mTOR and Drp1 in IL-1β-induced rat chondrocytes. However, 3-Methyladenine did the opposite effects of Baicalin and 740Y-P reversed the effects of Baicalin on IL-1β-induced rat chondrocytes. In conclusion, Baicalin activated mitophagy in IL-1β-induced chondrocytes by inhibiting PI3K/AKT/mTOR pathway and activating PINK1/Parkin and PINK1/Drp-1 pathway, thereby reducing the chondrocyte injury." @default.
• W4319461246 created "2023-02-09" @default.
• W4319461246 creator A5011699100 @default.
• W4319461246 creator A5065023946 @default.
• W4319461246 date "2023-03-05" @default.
• W4319461246 modified "2023-10-02" @default.
• W4319461246 title "Baicalin mitigated <scp>IL‐1β‐Induced</scp> osteoarthritis chondrocytes damage through activating mitophagy" @default.
• W4319461246 cites W1727558111 @default.
• W4319461246 cites W2013642338 @default.
• W4319461246 cites W2582731681 @default.
• W4319461246 cites W2593448862 @default.
• W4319461246 cites W2733919064 @default.
• W4319461246 cites W2737993948 @default.
• W4319461246 cites W2743405616 @default.
• W4319461246 cites W2765560649 @default.
• W4319461246 cites W2792881700 @default.
• W4319461246 cites W2897026563 @default.
• W4319461246 cites W2902044494 @default.
• W4319461246 cites W2910093369 @default.
• W4319461246 cites W2979872515 @default.
• W4319461246 cites W3005805254 @default.
• W4319461246 cites W3005812010 @default.
• W4319461246 cites W3007541218 @default.
• W4319461246 cites W3011565224 @default.
• W4319461246 cites W3028639839 @default.
• W4319461246 cites W3039409603 @default.
• W4319461246 cites W3081914921 @default.
• W4319461246 cites W3087972244 @default.
• W4319461246 cites W3107998825 @default.
• W4319461246 cites W3115872251 @default.
• W4319461246 cites W3175130560 @default.
• W4319461246 cites W4200513221 @default.
• W4319461246 doi "https://doi.org/10.1111/cbdd.14215" @default.
• W4319461246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36752698" @default.
• W4319461246 hasPublicationYear "2023" @default.
• W4319461246 type Work @default.
• W4319461246 citedByCount "3" @default.
• W4319461246 countsByYear W43194612462023 @default.
• W4319461246 crossrefType "journal-article" @default.
• W4319461246 hasAuthorship W4319461246A5011699100 @default.
• W4319461246 hasAuthorship W4319461246A5065023946 @default.
• W4319461246 hasConcept C126322002 @default.
• W4319461246 hasConcept C179998833 @default.
• W4319461246 hasConcept C185592680 @default.
• W4319461246 hasConcept C190283241 @default.
• W4319461246 hasConcept C202751555 @default.
• W4319461246 hasConcept C203522944 @default.
• W4319461246 hasConcept C2776804853 @default.
• W4319461246 hasConcept C2777668072 @default.
• W4319461246 hasConcept C2779134260 @default.
• W4319461246 hasConcept C2779324830 @default.
• W4319461246 hasConcept C2779734285 @default.
• W4319461246 hasConcept C2780113650 @default.
• W4319461246 hasConcept C2781403057 @default.
• W4319461246 hasConcept C43617362 @default.
• W4319461246 hasConcept C53227056 @default.
• W4319461246 hasConcept C55493867 @default.
• W4319461246 hasConcept C71924100 @default.
• W4319461246 hasConcept C75217442 @default.
• W4319461246 hasConcept C86554907 @default.
• W4319461246 hasConcept C86803240 @default.
• W4319461246 hasConcept C95444343 @default.
• W4319461246 hasConceptScore W4319461246C126322002 @default.
• W4319461246 hasConceptScore W4319461246C179998833 @default.
• W4319461246 hasConceptScore W4319461246C185592680 @default.
• W4319461246 hasConceptScore W4319461246C190283241 @default.
• W4319461246 hasConceptScore W4319461246C202751555 @default.
• W4319461246 hasConceptScore W4319461246C203522944 @default.
• W4319461246 hasConceptScore W4319461246C2776804853 @default.
• W4319461246 hasConceptScore W4319461246C2777668072 @default.
• W4319461246 hasConceptScore W4319461246C2779134260 @default.
• W4319461246 hasConceptScore W4319461246C2779324830 @default.
• W4319461246 hasConceptScore W4319461246C2779734285 @default.
• W4319461246 hasConceptScore W4319461246C2780113650 @default.
• W4319461246 hasConceptScore W4319461246C2781403057 @default.
• W4319461246 hasConceptScore W4319461246C43617362 @default.
• W4319461246 hasConceptScore W4319461246C53227056 @default.
• W4319461246 hasConceptScore W4319461246C55493867 @default.
• W4319461246 hasConceptScore W4319461246C71924100 @default.
• W4319461246 hasConceptScore W4319461246C75217442 @default.
• W4319461246 hasConceptScore W4319461246C86554907 @default.
• W4319461246 hasConceptScore W4319461246C86803240 @default.
• W4319461246 hasConceptScore W4319461246C95444343 @default.
• W4319461246 hasFunder F4320335784 @default.
• W4319461246 hasIssue "6" @default.
• W4319461246 hasLocation W43194612461 @default.
• W4319461246 hasLocation W43194612462 @default.
• W4319461246 hasOpenAccess W4319461246 @default.
• W4319461246 hasPrimaryLocation W43194612461 @default.
• W4319461246 hasRelatedWork W1555005787 @default.
• W4319461246 hasRelatedWork W2061633455 @default.
• W4319461246 hasRelatedWork W2106876891 @default.
• W4319461246 hasRelatedWork W2140570112 @default.
• W4319461246 hasRelatedWork W3037649426 @default.
• W4319461246 hasRelatedWork W3094078064 @default.
• W4319461246 hasRelatedWork W3196322306 @default.
• W4319461246 hasRelatedWork W4225529211 @default.
• W4319461246 hasRelatedWork W4319461246 @default.

• next