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- W4319461263 abstract "RNA strand cleavage by 2′-O-transphosphorylation is catalyzed not only by numerous nucleolytic RNA enzymes (ribozymes) but also by hydroxide or hydronium ions. In experiments, both cleavage of the 5′-linked nucleoside and isomerization between 3′,5′- and 2′,5′-phosphodiesters occur under acidic conditions, while only the cleavage reaction is observed under basic conditions. An ab initio path-integral approach for simulating kinetic isotope effects is used to reveal the reaction mechanisms for RNA cleavage and isomerization reactions under acidic conditions. Moreover, the proposed mechanisms can also be combined through the experimental pH-rate profiles." @default.
- W4319461263 created "2023-02-09" @default.
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- W4319461263 date "2023-02-08" @default.
- W4319461263 modified "2023-10-03" @default.
- W4319461263 title "Altered Mechanisms for Acid-Catalyzed RNA Cleavage and Isomerization Reactions Models" @default.
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- W4319461263 doi "https://doi.org/10.1021/acs.jctc.2c01277" @default.
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