FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319461702> ?p ?o ?g. }

• W4319461702 endingPage "E278" @default.
• W4319461702 startingPage "E268" @default.
• W4319461702 abstract "In pediatric population with diabetes and obesity, insulin resistance (HOMA-IR) has been associated with worsening vascular outcomes, however, the cumulative role of HOMA-IR, hyperglycemia, and hyperinsulinemia on repeatedly measured vascular outcomes in asymptomatic youth is unknown. We examined the longitudinal associations of fasting glucose, insulin, and HOMA-IR with carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT). From the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, UK 1,779, 15-yr-old participants were followed up for 9 yr. Glucose, insulin, and HOMA-IR assessed at 15, 17, and 24 yr and sex-specifically dichotomized as ≥75th percentile, indicating high category and <75th percentile as reference. cfPWV and cIMT were measured at ages 17 and 24 yr. Associations were examined using linear mixed-effect models adjusted for cardiometabolic and lifestyle covariates. Among 1,779 participants [49.9% female], glucose, insulin, and HOMA-IR had a J- or U-shaped increase from ages 15 through 24 yr. The cumulative exposures to hyperinsulinemia effect estimate -0.019 mU/L; [95% CI -0.019 to -0.002; P = 0.033] and high HOMA-IR: -0.021; [-0.039 to -0.004; P = 0.019] from 15 to 24 yr of age were negatively associated with the 7-yr cfPWV progression. Only cumulative hyperinsulinemia and high HOMA-IR from ages 15 to 17 yr but not from ages 17 to 24 yr was associated with decreased cfPWV progression. There were no associations between cumulative hyperglycemia and cfPWV or cIMT progression. Hyperinsulinemia and HOMA-IR were not associated with cIMT progression. In conclusion, late adolescence may be an optimal timing for intervention targeted at sustaining the protective effect of the decline of insulin and insulin resistance on arterial stiffness progression.NEW & NOTEWORTHY Fasting plasma glucose, insulin, and insulin resistance had a J- or U-shaped increase from 15 to 24 yr with the base of the curve at age 17 yr. Cumulative high insulin and high insulin resistance from 15 to 24 yr were negatively associated with arterial stiffness progression from ages 17 to 24 yr. Age 17 yr may be an optimal timing for intervention targeted at sustaining the protective effect of the decline of insulin and insulin resistance on arterial stiffness progression." @default.
• W4319461702 created "2023-02-09" @default.
• W4319461702 creator A5014898551 @default.
• W4319461702 creator A5024928026 @default.
• W4319461702 creator A5034796233 @default.
• W4319461702 creator A5048465221 @default.
• W4319461702 creator A5060791374 @default.
• W4319461702 date "2023-03-01" @default.
• W4319461702 modified "2023-10-18" @default.
• W4319461702 title "Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study" @default.
• W4319461702 cites W122349615 @default.
• W4319461702 cites W1589240455 @default.
• W4319461702 cites W2006085701 @default.
• W4319461702 cites W2010331469 @default.
• W4319461702 cites W2055032808 @default.
• W4319461702 cites W2081240175 @default.
• W4319461702 cites W2083745787 @default.
• W4319461702 cites W2094550322 @default.
• W4319461702 cites W2122725779 @default.
• W4319461702 cites W2123263006 @default.
• W4319461702 cites W2124620553 @default.
• W4319461702 cites W2138585828 @default.
• W4319461702 cites W2142739662 @default.
• W4319461702 cites W2143509157 @default.
• W4319461702 cites W2165256339 @default.
• W4319461702 cites W2491849061 @default.
• W4319461702 cites W2558622935 @default.
• W4319461702 cites W2777124428 @default.
• W4319461702 cites W2884148557 @default.
• W4319461702 cites W2888589263 @default.
• W4319461702 cites W2921400779 @default.
• W4319461702 cites W2944434778 @default.
• W4319461702 cites W2945567688 @default.
• W4319461702 cites W2971164718 @default.
• W4319461702 cites W3018567854 @default.
• W4319461702 cites W3023205880 @default.
• W4319461702 cites W3133961129 @default.
• W4319461702 cites W3143456229 @default.
• W4319461702 cites W3144235332 @default.
• W4319461702 cites W3199177120 @default.
• W4319461702 cites W3212509242 @default.
• W4319461702 cites W4214854466 @default.
• W4319461702 cites W4220718856 @default.
• W4319461702 cites W4226418409 @default.
• W4319461702 cites W4231317903 @default.
• W4319461702 cites W4285396552 @default.
• W4319461702 cites W4306178430 @default.
• W4319461702 cites W4309081339 @default.
• W4319461702 cites W4318920672 @default.
• W4319461702 doi "https://doi.org/10.1152/ajpendo.00008.2023" @default.
• W4319461702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36753290" @default.
• W4319461702 hasPublicationYear "2023" @default.
• W4319461702 type Work @default.
• W4319461702 citedByCount "5" @default.
• W4319461702 countsByYear W43194617022023 @default.
• W4319461702 crossrefType "journal-article" @default.
• W4319461702 hasAuthorship W4319461702A5014898551 @default.
• W4319461702 hasAuthorship W4319461702A5024928026 @default.
• W4319461702 hasAuthorship W4319461702A5034796233 @default.
• W4319461702 hasAuthorship W4319461702A5048465221 @default.
• W4319461702 hasAuthorship W4319461702A5060791374 @default.
• W4319461702 hasConcept C126322002 @default.
• W4319461702 hasConcept C134018914 @default.
• W4319461702 hasConcept C142724271 @default.
• W4319461702 hasConcept C164705383 @default.
• W4319461702 hasConcept C2775850156 @default.
• W4319461702 hasConcept C2777391703 @default.
• W4319461702 hasConcept C2777895361 @default.
• W4319461702 hasConcept C2777910003 @default.
• W4319461702 hasConcept C2778319312 @default.
• W4319461702 hasConcept C2779306644 @default.
• W4319461702 hasConcept C2780988686 @default.
• W4319461702 hasConcept C2908647359 @default.
• W4319461702 hasConcept C555293320 @default.
• W4319461702 hasConcept C71924100 @default.
• W4319461702 hasConcept C72563966 @default.
• W4319461702 hasConcept C84393581 @default.
• W4319461702 hasConcept C99454951 @default.
• W4319461702 hasConceptScore W4319461702C126322002 @default.
• W4319461702 hasConceptScore W4319461702C134018914 @default.
• W4319461702 hasConceptScore W4319461702C142724271 @default.
• W4319461702 hasConceptScore W4319461702C164705383 @default.
• W4319461702 hasConceptScore W4319461702C2775850156 @default.
• W4319461702 hasConceptScore W4319461702C2777391703 @default.
• W4319461702 hasConceptScore W4319461702C2777895361 @default.
• W4319461702 hasConceptScore W4319461702C2777910003 @default.
• W4319461702 hasConceptScore W4319461702C2778319312 @default.
• W4319461702 hasConceptScore W4319461702C2779306644 @default.
• W4319461702 hasConceptScore W4319461702C2780988686 @default.
• W4319461702 hasConceptScore W4319461702C2908647359 @default.
• W4319461702 hasConceptScore W4319461702C555293320 @default.
• W4319461702 hasConceptScore W4319461702C71924100 @default.
• W4319461702 hasConceptScore W4319461702C72563966 @default.
• W4319461702 hasConceptScore W4319461702C84393581 @default.
• W4319461702 hasConceptScore W4319461702C99454951 @default.
• W4319461702 hasFunder F4320311795 @default.
• W4319461702 hasFunder F4320311814 @default.
• W4319461702 hasFunder F4320311904 @default.

• next