Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319461778> ?p ?o ?g. }
- W4319461778 endingPage "1306" @default.
- W4319461778 startingPage "1299" @default.
- W4319461778 abstract "Abstract In this study, five neolignans were isolated from Saururus cernuus — threo‐ dihydroguaiaretic acid ( 1 ), threo ‐austrobailignan‐6 ( 2 ), threo‐ austrobailignan‐5 ( 3 ), verrucosin ( 4 ), and saucernetin ( 5 )—and have their cytotoxic effects evaluated in prostate cancer cell lines (PC3 and DU145). Initially, using an in silico approach, tested compounds were predicted to be absorbed by the gastrointestinal tract, be able to permeate the blood–brain barrier and did not show any alert in PAINS (pan‐assay structures interference). In vitro assays showed that compounds 2 , 4 , and 5 reduced cell viability of DU145 cell line at 100 μmol/L after 48 h while compounds 1 and 3 showed to be inactive at the same conditions. Furthermore, compounds 4 and 5 reduced cell number as early as in 24 h at 50 μmol/L and compound 2 showed effects at 100 μmol/L in 24 h against both cancer cell lines PC3 and DU145. Studies using flow cytometry were conducted and indicated that compound 4 induced strong necrosis and apoptosis whereas compound 5 induced strong necrosis. Otherwise, less active compound 2 did not show evidence of induction of apoptosis or necrosis, suggesting that its mechanism of action involves inhibition of cell proliferation. In conclusion, compounds 4 and 5 have been shown to be promising cytotoxic agents against prostate cancer cell lines and can be used as a starting point for the development of new drugs for the treatment of prostate cancer." @default.
- W4319461778 created "2023-02-09" @default.
- W4319461778 creator A5010680141 @default.
- W4319461778 creator A5011149867 @default.
- W4319461778 creator A5020050669 @default.
- W4319461778 creator A5023312075 @default.
- W4319461778 creator A5036698250 @default.
- W4319461778 creator A5039634567 @default.
- W4319461778 creator A5046061548 @default.
- W4319461778 creator A5087571815 @default.
- W4319461778 date "2023-02-27" @default.
- W4319461778 modified "2023-10-15" @default.
- W4319461778 title "Cytotoxic effects of neolignans from <i>Saururus cernuus</i> (Saururaceae) against prostate cancer cells" @default.
- W4319461778 cites W1575971200 @default.
- W4319461778 cites W1967446225 @default.
- W4319461778 cites W1984666934 @default.
- W4319461778 cites W2010427019 @default.
- W4319461778 cites W2020744113 @default.
- W4319461778 cites W2041643550 @default.
- W4319461778 cites W2147433368 @default.
- W4319461778 cites W2293595839 @default.
- W4319461778 cites W2593436234 @default.
- W4319461778 cites W2743350540 @default.
- W4319461778 cites W2955871322 @default.
- W4319461778 cites W2979656821 @default.
- W4319461778 cites W3128646645 @default.
- W4319461778 cites W4206841660 @default.
- W4319461778 cites W4223424667 @default.
- W4319461778 cites W4281731579 @default.
- W4319461778 cites W4285733720 @default.
- W4319461778 cites W2035174674 @default.
- W4319461778 doi "https://doi.org/10.1111/cbdd.14213" @default.
- W4319461778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36752700" @default.
- W4319461778 hasPublicationYear "2023" @default.
- W4319461778 type Work @default.
- W4319461778 citedByCount "0" @default.
- W4319461778 crossrefType "journal-article" @default.
- W4319461778 hasAuthorship W4319461778A5010680141 @default.
- W4319461778 hasAuthorship W4319461778A5011149867 @default.
- W4319461778 hasAuthorship W4319461778A5020050669 @default.
- W4319461778 hasAuthorship W4319461778A5023312075 @default.
- W4319461778 hasAuthorship W4319461778A5036698250 @default.
- W4319461778 hasAuthorship W4319461778A5039634567 @default.
- W4319461778 hasAuthorship W4319461778A5046061548 @default.
- W4319461778 hasAuthorship W4319461778A5087571815 @default.
- W4319461778 hasConcept C109316439 @default.
- W4319461778 hasConcept C121608353 @default.
- W4319461778 hasConcept C126322002 @default.
- W4319461778 hasConcept C153911025 @default.
- W4319461778 hasConcept C154317977 @default.
- W4319461778 hasConcept C17991360 @default.
- W4319461778 hasConcept C185592680 @default.
- W4319461778 hasConcept C190283241 @default.
- W4319461778 hasConcept C202751555 @default.
- W4319461778 hasConcept C203014093 @default.
- W4319461778 hasConcept C2776438761 @default.
- W4319461778 hasConcept C2779723316 @default.
- W4319461778 hasConcept C2780192828 @default.
- W4319461778 hasConcept C503630168 @default.
- W4319461778 hasConcept C53227056 @default.
- W4319461778 hasConcept C54355233 @default.
- W4319461778 hasConcept C553184892 @default.
- W4319461778 hasConcept C55493867 @default.
- W4319461778 hasConcept C71924100 @default.
- W4319461778 hasConcept C81885089 @default.
- W4319461778 hasConcept C86803240 @default.
- W4319461778 hasConcept C96232424 @default.
- W4319461778 hasConcept C98274493 @default.
- W4319461778 hasConceptScore W4319461778C109316439 @default.
- W4319461778 hasConceptScore W4319461778C121608353 @default.
- W4319461778 hasConceptScore W4319461778C126322002 @default.
- W4319461778 hasConceptScore W4319461778C153911025 @default.
- W4319461778 hasConceptScore W4319461778C154317977 @default.
- W4319461778 hasConceptScore W4319461778C17991360 @default.
- W4319461778 hasConceptScore W4319461778C185592680 @default.
- W4319461778 hasConceptScore W4319461778C190283241 @default.
- W4319461778 hasConceptScore W4319461778C202751555 @default.
- W4319461778 hasConceptScore W4319461778C203014093 @default.
- W4319461778 hasConceptScore W4319461778C2776438761 @default.
- W4319461778 hasConceptScore W4319461778C2779723316 @default.
- W4319461778 hasConceptScore W4319461778C2780192828 @default.
- W4319461778 hasConceptScore W4319461778C503630168 @default.
- W4319461778 hasConceptScore W4319461778C53227056 @default.
- W4319461778 hasConceptScore W4319461778C54355233 @default.
- W4319461778 hasConceptScore W4319461778C553184892 @default.
- W4319461778 hasConceptScore W4319461778C55493867 @default.
- W4319461778 hasConceptScore W4319461778C71924100 @default.
- W4319461778 hasConceptScore W4319461778C81885089 @default.
- W4319461778 hasConceptScore W4319461778C86803240 @default.
- W4319461778 hasConceptScore W4319461778C96232424 @default.
- W4319461778 hasConceptScore W4319461778C98274493 @default.
- W4319461778 hasFunder F4320320997 @default.
- W4319461778 hasFunder F4320322025 @default.
- W4319461778 hasIssue "6" @default.
- W4319461778 hasLocation W43194617781 @default.
- W4319461778 hasLocation W43194617782 @default.
- W4319461778 hasOpenAccess W4319461778 @default.
- W4319461778 hasPrimaryLocation W43194617781 @default.