FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319461805> ?p ?o ?g. }

• W4319461805 abstract "Some microorganisms, i.e., Candida albicans, have been associated with cancer onset and development, although whether the fungus promotes cancer or whether cancer facilitates the growth of C. albicans is unclear. In this context, microbial-derived molecules can modulate the growth and resistance of cancer cells. This study isolated extracellular lipids (ECL) from a 36-h Candida albicans biofilm incubated with oral dysplastic (DOK) and neoplastic (SCC 25) cells, which were further challenged with the topoisomerase I inhibitor camptothecin (CPT), a lipophilic anti-tumoral molecule.ECL were extracted from a 36-h Candida albicans biofilm with the methanol/chloroform precipitation method and identified with Nuclear Magnetic Resonance (1H-NMR). The MTT tetrazolium assay measured ECL cytotoxicity in DOK and SCC 25 cells, alamarBlue™ assessed cell metabolism, flow cytometry measured cell cycle, and confocal microscopy determined intracellular features.Three major classes of ECL of C. albicans biofilm were found: phosphatidylinositol (PI), phosphatidylcholine (PC), and phosphatidylglycerol (PG). The ECL of C. albicans biofilm had no cytotoxic effect on neither cell after 24 hours, with a tendency to disturb the SCC 25 cell cycle profile (without statistical significance). The ECL-induced intracellular lipid droplet (LD) formation on both cell lines after 72 hours. In this context, ECL enhanced cell metabolism, decreased the response to CPT, and modified intracellular drug distribution.The ECL (PI, PC, and PG) of 36-h Candida albicans biofilm directly interacts with dysplastic and neoplastic oral cells, highlighting the relevance of better understanding C. albicans biofilm signaling in the microenvironment of tumor cells." @default.
• W4319461805 created "2023-02-09" @default.
• W4319461805 creator A5023956780 @default.
• W4319461805 creator A5029634012 @default.
• W4319461805 creator A5043245640 @default.
• W4319461805 creator A5056166000 @default.
• W4319461805 creator A5067917704 @default.
• W4319461805 creator A5069754869 @default.
• W4319461805 date "2022-01-01" @default.
• W4319461805 modified "2023-09-30" @default.
• W4319461805 title "Extracellular lipids of Candida albicans biofilm induce lipid droplet formation and decreased response to a topoisomerase I inhibitor in dysplastic and neoplastic oral cells" @default.
• W4319461805 cites W1503057784 @default.
• W4319461805 cites W1844107241 @default.
• W4319461805 cites W1966150667 @default.
• W4319461805 cites W1975065411 @default.
• W4319461805 cites W1980207927 @default.
• W4319461805 cites W1991275052 @default.
• W4319461805 cites W1993952805 @default.
• W4319461805 cites W2020681708 @default.
• W4319461805 cites W2024559844 @default.
• W4319461805 cites W2089526905 @default.
• W4319461805 cites W2149297795 @default.
• W4319461805 cites W2260815707 @default.
• W4319461805 cites W2320043029 @default.
• W4319461805 cites W2480418585 @default.
• W4319461805 cites W2767837179 @default.
• W4319461805 cites W2768799378 @default.
• W4319461805 cites W2769911208 @default.
• W4319461805 cites W2775715535 @default.
• W4319461805 cites W2786541232 @default.
• W4319461805 cites W2801054474 @default.
• W4319461805 cites W2816954247 @default.
• W4319461805 cites W2894968361 @default.
• W4319461805 cites W2904988746 @default.
• W4319461805 cites W3001738994 @default.
• W4319461805 cites W3006662803 @default.
• W4319461805 cites W3038920130 @default.
• W4319461805 cites W3044908880 @default.
• W4319461805 cites W3094268377 @default.
• W4319461805 cites W3131603248 @default.
• W4319461805 cites W3134281012 @default.
• W4319461805 cites W4206433499 @default.
• W4319461805 cites W4210803397 @default.
• W4319461805 cites W4297069849 @default.
• W4319461805 cites W4298008684 @default.
• W4319461805 cites W4298008749 @default.
• W4319461805 doi "https://doi.org/10.1590/1678-7757-2022-0319" @default.
• W4319461805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36753070" @default.
• W4319461805 hasPublicationYear "2022" @default.
• W4319461805 type Work @default.
• W4319461805 citedByCount "1" @default.
• W4319461805 countsByYear W43194618052023 @default.
• W4319461805 crossrefType "journal-article" @default.
• W4319461805 hasAuthorship W4319461805A5023956780 @default.
• W4319461805 hasAuthorship W4319461805A5029634012 @default.
• W4319461805 hasAuthorship W4319461805A5043245640 @default.
• W4319461805 hasAuthorship W4319461805A5056166000 @default.
• W4319461805 hasAuthorship W4319461805A5067917704 @default.
• W4319461805 hasAuthorship W4319461805A5069754869 @default.
• W4319461805 hasBestOaLocation W43194618051 @default.
• W4319461805 hasConcept C121608353 @default.
• W4319461805 hasConcept C145081991 @default.
• W4319461805 hasConcept C1491633281 @default.
• W4319461805 hasConcept C151730666 @default.
• W4319461805 hasConcept C153911025 @default.
• W4319461805 hasConcept C185592680 @default.
• W4319461805 hasConcept C2779343474 @default.
• W4319461805 hasConcept C2779682216 @default.
• W4319461805 hasConcept C2780917455 @default.
• W4319461805 hasConcept C28406088 @default.
• W4319461805 hasConcept C29537977 @default.
• W4319461805 hasConcept C523546767 @default.
• W4319461805 hasConcept C54355233 @default.
• W4319461805 hasConcept C553184892 @default.
• W4319461805 hasConcept C55493867 @default.
• W4319461805 hasConcept C58123911 @default.
• W4319461805 hasConcept C62112901 @default.
• W4319461805 hasConcept C79879829 @default.
• W4319461805 hasConcept C86803240 @default.
• W4319461805 hasConcept C89423630 @default.
• W4319461805 hasConcept C96232424 @default.
• W4319461805 hasConceptScore W4319461805C121608353 @default.
• W4319461805 hasConceptScore W4319461805C145081991 @default.
• W4319461805 hasConceptScore W4319461805C1491633281 @default.
• W4319461805 hasConceptScore W4319461805C151730666 @default.
• W4319461805 hasConceptScore W4319461805C153911025 @default.
• W4319461805 hasConceptScore W4319461805C185592680 @default.
• W4319461805 hasConceptScore W4319461805C2779343474 @default.
• W4319461805 hasConceptScore W4319461805C2779682216 @default.
• W4319461805 hasConceptScore W4319461805C2780917455 @default.
• W4319461805 hasConceptScore W4319461805C28406088 @default.
• W4319461805 hasConceptScore W4319461805C29537977 @default.
• W4319461805 hasConceptScore W4319461805C523546767 @default.
• W4319461805 hasConceptScore W4319461805C54355233 @default.
• W4319461805 hasConceptScore W4319461805C553184892 @default.
• W4319461805 hasConceptScore W4319461805C55493867 @default.
• W4319461805 hasConceptScore W4319461805C58123911 @default.
• W4319461805 hasConceptScore W4319461805C62112901 @default.
• W4319461805 hasConceptScore W4319461805C79879829 @default.
• W4319461805 hasConceptScore W4319461805C86803240 @default.

• next