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• W4319461952 abstract "Abstract Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca 2+ uptake dynamics through the mitochondrial Ca 2+ uniporter (MCU) complex. In particular, Ca 2+ uptake regulates the mitochondrial ATP production, mitochondrial dynamics, oxidative stress, and cell death. Therefore, modulating the activity of the MCU complex to regulate Ca 2+ uptake, has been suggested as a potential therapeutic approach for the treatment of CVDs. Here, the role and implications of the MCU complex in CVDs are presented, followed by a review of the evidence for MCU complex modulation, genetically and pharmacologically. While most approaches have aimed within the MCU complex for the modulation of the Ca 2+ pore channel, the MCU subunit, its intra‐ and extra‐ mitochondrial implications, including Ca 2+ dynamics, oxidative stress, post‐translational modifications, and its repercussions in the cardiac function, highlight that targeting the MCU complex has the translational potential for novel CVDs therapeutics." @default.
• W4319461952 created "2023-02-09" @default.
• W4319461952 creator A5001937719 @default.
• W4319461952 creator A5016794330 @default.
• W4319461952 creator A5031093969 @default.
• W4319461952 creator A5033009245 @default.
• W4319461952 creator A5048145260 @default.
• W4319461952 creator A5053083115 @default.
• W4319461952 date "2023-02-24" @default.
• W4319461952 modified "2023-10-15" @default.
• W4319461952 title "Targeting the mitochondrial Ca²⁺ uniporter complex in cardiovascular disease" @default.
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