Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319593251> ?p ?o ?g. }
- W4319593251 abstract "Abstract Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2 infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant IFN-I/λ source following their sensing of SARS-CoV-2-infected cells. Mechanistically, this short-range sensing by pDCs requires sustained integrin-mediated cell adhesion with infected cells. In turn, pDCs restrict viral spread by an IFN-I/λ response directed toward SARS-CoV-2-infected cells. This specialized function enables pDCs to efficiently turn-off viral replication, likely via a local response at the contact site with infected cells. By exploring the pDC response in SARS-CoV-2 patients, we further demonstrate that pDC responsiveness inversely correlates with the severity of the disease. The pDC response is particularly impaired in severe COVID-19 patients. Overall, we propose that pDC activation is essential to control SARS-CoV-2-infection. Failure to develop this response could be important to understand severe cases of COVID-19." @default.
- W4319593251 created "2023-02-09" @default.
- W4319593251 creator A5012448742 @default.
- W4319593251 creator A5015662381 @default.
- W4319593251 creator A5020888771 @default.
- W4319593251 creator A5023348421 @default.
- W4319593251 creator A5024860407 @default.
- W4319593251 creator A5025261146 @default.
- W4319593251 creator A5027228833 @default.
- W4319593251 creator A5043853010 @default.
- W4319593251 creator A5045691072 @default.
- W4319593251 creator A5055609461 @default.
- W4319593251 creator A5060157202 @default.
- W4319593251 creator A5060477972 @default.
- W4319593251 creator A5063454345 @default.
- W4319593251 creator A5066148128 @default.
- W4319593251 creator A5074367743 @default.
- W4319593251 creator A5078453674 @default.
- W4319593251 creator A5085289068 @default.
- W4319593251 date "2023-02-08" @default.
- W4319593251 modified "2023-10-18" @default.
- W4319593251 title "Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2" @default.
- W4319593251 cites W1678356000 @default.
- W4319593251 cites W1855946711 @default.
- W4319593251 cites W1967538535 @default.
- W4319593251 cites W1977728069 @default.
- W4319593251 cites W1987313116 @default.
- W4319593251 cites W1997977259 @default.
- W4319593251 cites W2016749309 @default.
- W4319593251 cites W2020172485 @default.
- W4319593251 cites W2049762266 @default.
- W4319593251 cites W2053295791 @default.
- W4319593251 cites W2064959743 @default.
- W4319593251 cites W2066167790 @default.
- W4319593251 cites W2070493638 @default.
- W4319593251 cites W2071189249 @default.
- W4319593251 cites W2072109464 @default.
- W4319593251 cites W2076123445 @default.
- W4319593251 cites W2091064323 @default.
- W4319593251 cites W2091790511 @default.
- W4319593251 cites W2094781325 @default.
- W4319593251 cites W2099158550 @default.
- W4319593251 cites W2111334411 @default.
- W4319593251 cites W2115536654 @default.
- W4319593251 cites W2128440643 @default.
- W4319593251 cites W2140952049 @default.
- W4319593251 cites W2156661861 @default.
- W4319593251 cites W2161092473 @default.
- W4319593251 cites W2162614357 @default.
- W4319593251 cites W2166221102 @default.
- W4319593251 cites W2168028214 @default.
- W4319593251 cites W2267315119 @default.
- W4319593251 cites W2326721495 @default.
- W4319593251 cites W2338447065 @default.
- W4319593251 cites W2543632691 @default.
- W4319593251 cites W2555213202 @default.
- W4319593251 cites W2587291131 @default.
- W4319593251 cites W2591587054 @default.
- W4319593251 cites W2605810679 @default.
- W4319593251 cites W2763770180 @default.
- W4319593251 cites W2769592732 @default.
- W4319593251 cites W2775143705 @default.
- W4319593251 cites W2802753517 @default.
- W4319593251 cites W2808775113 @default.
- W4319593251 cites W2899944908 @default.
- W4319593251 cites W2908943028 @default.
- W4319593251 cites W2911964244 @default.
- W4319593251 cites W2936471740 @default.
- W4319593251 cites W2936804536 @default.
- W4319593251 cites W2945529854 @default.
- W4319593251 cites W2971798665 @default.
- W4319593251 cites W3003464757 @default.
- W4319593251 cites W3014663601 @default.
- W4319593251 cites W3015751519 @default.
- W4319593251 cites W3016489853 @default.
- W4319593251 cites W3020655115 @default.
- W4319593251 cites W3021565497 @default.
- W4319593251 cites W3030537287 @default.
- W4319593251 cites W3036190795 @default.
- W4319593251 cites W3041960835 @default.
- W4319593251 cites W3042511456 @default.
- W4319593251 cites W3043831218 @default.
- W4319593251 cites W3044711307 @default.
- W4319593251 cites W3044799813 @default.
- W4319593251 cites W3045552416 @default.
- W4319593251 cites W3045802278 @default.
- W4319593251 cites W3047202996 @default.
- W4319593251 cites W3047880178 @default.
- W4319593251 cites W3087744389 @default.
- W4319593251 cites W3087862874 @default.
- W4319593251 cites W3088256443 @default.
- W4319593251 cites W3091384134 @default.
- W4319593251 cites W3094558943 @default.
- W4319593251 cites W3107596380 @default.
- W4319593251 cites W3108832674 @default.
- W4319593251 cites W3112300343 @default.
- W4319593251 cites W3122869867 @default.
- W4319593251 cites W3124454689 @default.
- W4319593251 cites W3131568121 @default.
- W4319593251 cites W3132139105 @default.