Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319598186> ?p ?o ?g. }
- W4319598186 endingPage "400" @default.
- W4319598186 startingPage "400" @default.
- W4319598186 abstract "Fractional exhaled nitric oxide (FeNO) is a biomarker of airway inflammation associated with airway hyper-responsiveness and type-2 inflammation. Its role in the management of severe asthmatic patients undergoing biologic treatment, as well as FeNO dynamics during biologic treatment, is largely unexplored.The aim was to evaluate published data contributing to the following areas: (1) FeNO as a predictive biomarker of response to biologic treatment; (2) the influence of biologic treatment in FeNO values; (3) FeNO as a biomarker for the prediction of exacerbations in patients treated with biologics.The systematic search was conducted on the Medline database through the Pubmed search engine, including all studies from 2009 to the present.Higher baseline values of FeNO are associated with better clinical control in patients treated with omalizumab, dupilumab, and tezepelumab. FeNO dynamics during biologic treatment highlights a clear reduction in FeNO values in patients treated with anti-IL4/13 and anti-IL13, as well as in patients treated with tezepelumab. During the treatment, FeNO may help to predict clinical worsening and to differentiate eosinophilic from non-eosinophilic exacerbations.Higher baseline FeNO levels appear to be associated with a greater benefit in terms of clinical control and reduction of exacerbation rate, while FeNO dynamics during biologic treatment remains a largely unexplored issue since few studies have investigated it as a primary outcome. FeNO remains detectable during biologic treatment, but its potential utility as a biomarker of clinical control is still unclear and represents an interesting research area to be developed." @default.
- W4319598186 created "2023-02-09" @default.
- W4319598186 creator A5001098559 @default.
- W4319598186 creator A5013985509 @default.
- W4319598186 creator A5021360738 @default.
- W4319598186 creator A5026219250 @default.
- W4319598186 creator A5027529004 @default.
- W4319598186 creator A5032858975 @default.
- W4319598186 creator A5033753974 @default.
- W4319598186 creator A5036300020 @default.
- W4319598186 creator A5045093097 @default.
- W4319598186 creator A5082781749 @default.
- W4319598186 creator A5062057053 @default.
- W4319598186 date "2023-02-07" @default.
- W4319598186 modified "2023-10-18" @default.
- W4319598186 title "Exploring the Interaction between Fractional Exhaled Nitric Oxide and Biologic Treatment in Severe Asthma: A Systematic Review" @default.
- W4319598186 cites W1971325026 @default.
- W4319598186 cites W1988758075 @default.
- W4319598186 cites W2015379751 @default.
- W4319598186 cites W2019456214 @default.
- W4319598186 cites W2025232743 @default.
- W4319598186 cites W2028161597 @default.
- W4319598186 cites W2073559918 @default.
- W4319598186 cites W2095754126 @default.
- W4319598186 cites W2098276532 @default.
- W4319598186 cites W2114436422 @default.
- W4319598186 cites W2121954044 @default.
- W4319598186 cites W2127482775 @default.
- W4319598186 cites W2138355864 @default.
- W4319598186 cites W2160134481 @default.
- W4319598186 cites W2472937739 @default.
- W4319598186 cites W2548196387 @default.
- W4319598186 cites W2581649500 @default.
- W4319598186 cites W2589337206 @default.
- W4319598186 cites W2735493776 @default.
- W4319598186 cites W2752584372 @default.
- W4319598186 cites W2753143024 @default.
- W4319598186 cites W2801148110 @default.
- W4319598186 cites W2803404900 @default.
- W4319598186 cites W2803625106 @default.
- W4319598186 cites W2803941918 @default.
- W4319598186 cites W2804085823 @default.
- W4319598186 cites W2805002966 @default.
- W4319598186 cites W2902083791 @default.
- W4319598186 cites W2914737408 @default.
- W4319598186 cites W2918458940 @default.
- W4319598186 cites W2936528939 @default.
- W4319598186 cites W2937418718 @default.
- W4319598186 cites W2959333994 @default.
- W4319598186 cites W2977065657 @default.
- W4319598186 cites W2979915544 @default.
- W4319598186 cites W2980189835 @default.
- W4319598186 cites W2990079710 @default.
- W4319598186 cites W3002274027 @default.
- W4319598186 cites W3014452632 @default.
- W4319598186 cites W3015403258 @default.
- W4319598186 cites W3022195529 @default.
- W4319598186 cites W3032990105 @default.
- W4319598186 cites W3037599763 @default.
- W4319598186 cites W3038486779 @default.
- W4319598186 cites W3046423181 @default.
- W4319598186 cites W3085221855 @default.
- W4319598186 cites W3091873182 @default.
- W4319598186 cites W3111857896 @default.
- W4319598186 cites W3124157949 @default.
- W4319598186 cites W3126913318 @default.
- W4319598186 cites W3130012184 @default.
- W4319598186 cites W3131813990 @default.
- W4319598186 cites W3133660184 @default.
- W4319598186 cites W3135683706 @default.
- W4319598186 cites W3157208610 @default.
- W4319598186 cites W3157365672 @default.
- W4319598186 cites W3162024685 @default.
- W4319598186 cites W3165365105 @default.
- W4319598186 cites W3168769441 @default.
- W4319598186 cites W3181891508 @default.
- W4319598186 cites W3185166584 @default.
- W4319598186 cites W3193018472 @default.
- W4319598186 cites W4200568464 @default.
- W4319598186 cites W4210680851 @default.
- W4319598186 cites W4226146559 @default.
- W4319598186 cites W4280648526 @default.
- W4319598186 cites W4283277641 @default.
- W4319598186 cites W4292737569 @default.
- W4319598186 doi "https://doi.org/10.3390/antiox12020400" @default.
- W4319598186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36829959" @default.
- W4319598186 hasPublicationYear "2023" @default.
- W4319598186 type Work @default.
- W4319598186 citedByCount "4" @default.
- W4319598186 countsByYear W43195981862023 @default.
- W4319598186 crossrefType "journal-article" @default.
- W4319598186 hasAuthorship W4319598186A5001098559 @default.
- W4319598186 hasAuthorship W4319598186A5013985509 @default.
- W4319598186 hasAuthorship W4319598186A5021360738 @default.
- W4319598186 hasAuthorship W4319598186A5026219250 @default.
- W4319598186 hasAuthorship W4319598186A5027529004 @default.
- W4319598186 hasAuthorship W4319598186A5032858975 @default.
- W4319598186 hasAuthorship W4319598186A5033753974 @default.