FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319598766> ?p ?o ?g. }

• W4319598766 endingPage "1343" @default.
• W4319598766 startingPage "1343" @default.
• W4319598766 abstract "To date, the combined effect of polygenic risk score (PRS) and prostate health index (phi) on PCa diagnosis in men undergoing prostate biopsy has never been investigated. A total of 3166 patients who underwent initial prostate biopsy in three tertiary medical centers from August 2013 to March 2019 were included. PRS was calculated on the basis of the genotype of 102 reported East-Asian-specific risk variants. It was then evaluated in the univariable or multivariable logistic regression models that were internally validated using repeated 10-fold cross-validation. Discriminative performance was assessed by area under the receiver operating curve (AUC) and net reclassification improvement (NRI) index. Compared with men in the first quintile of age and family history adjusted PRS, those in the second, third, fourth, and fifth quintiles were 1.86 (odds ratio, 95% confidence interval (CI): 1.34-2.56), 2.07 (95%CI: 1.50-2.84), 3.26 (95%CI: 2.36-4.48), and 5.06 (95%CI: 3.68-6.97) times as likely to develop PCa (all p < 0.001). Adjustment for other clinical parameters yielded similar results. Among patients with prostate-specific antigen (PSA) at 2-10 ng/mL or 2-20 ng/mL, PRS still had an observable ability to differentiate PCa in the group of prostate health index (phi) at 27-36 (Ptrend < 0.05) or >36 (Ptrend ≤ 0.001). Notably, men with moderate phi (27-36) but highest PRS (top 20% percentile) would have a comparable risk of PCa (positive rate: 26.7% or 31.3%) than men with high phi (>36) but lowest PRS (bottom 20% percentile positive rate: 27.4% or 34.2%). The combined model of PRS, phi, and other clinical risk factors provided significantly better performance (AUC: 0.904, 95%CI: 0.887-0.921) than models without PRS. Adding PRS to clinical risk models could provide significant net benefit (NRI, from 8.6% to 27.6%), especially in those early onset patients (NRI, from 29.2% to 44.9%). PRS may provide additional predictive value over phi for PCa. The combination of PRS and phi that effectively captured both clinical and genetic PCa risk is clinically practical, even in patients with gray-zone PSA." @default.
• W4319598766 created "2023-02-09" @default.
• W4319598766 creator A5004304551 @default.
• W4319598766 creator A5005460814 @default.
• W4319598766 creator A5007778668 @default.
• W4319598766 creator A5010238073 @default.
• W4319598766 creator A5024208145 @default.
• W4319598766 creator A5026213634 @default.
• W4319598766 creator A5039786650 @default.
• W4319598766 creator A5063965056 @default.
• W4319598766 creator A5075256301 @default.
• W4319598766 creator A5077353181 @default.
• W4319598766 creator A5077703699 @default.
• W4319598766 date "2023-02-08" @default.
• W4319598766 modified "2023-09-30" @default.
• W4319598766 title "The Combined Effect of Polygenic Risk Score and Prostate Health Index in Chinese Men Undergoing Prostate Biopsy" @default.
• W4319598766 cites W1638938968 @default.
• W4319598766 cites W1683403935 @default.
• W4319598766 cites W1951305990 @default.
• W4319598766 cites W1970876554 @default.
• W4319598766 cites W2045030989 @default.
• W4319598766 cites W2148934838 @default.
• W4319598766 cites W2159803932 @default.
• W4319598766 cites W2168138611 @default.
• W4319598766 cites W2284253967 @default.
• W4319598766 cites W2412700507 @default.
• W4319598766 cites W2510973425 @default.
• W4319598766 cites W2731682278 @default.
• W4319598766 cites W2783014571 @default.
• W4319598766 cites W2896441111 @default.
• W4319598766 cites W2956705941 @default.
• W4319598766 cites W3092454105 @default.
• W4319598766 cites W3134889720 @default.
• W4319598766 cites W3158059286 @default.
• W4319598766 cites W3168595909 @default.
• W4319598766 cites W3181832309 @default.
• W4319598766 cites W4205318283 @default.
• W4319598766 cites W4226157785 @default.
• W4319598766 cites W4292833925 @default.
• W4319598766 doi "https://doi.org/10.3390/jcm12041343" @default.
• W4319598766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36835879" @default.
• W4319598766 hasPublicationYear "2023" @default.
• W4319598766 type Work @default.
• W4319598766 citedByCount "0" @default.
• W4319598766 crossrefType "journal-article" @default.
• W4319598766 hasAuthorship W4319598766A5004304551 @default.
• W4319598766 hasAuthorship W4319598766A5005460814 @default.
• W4319598766 hasAuthorship W4319598766A5007778668 @default.
• W4319598766 hasAuthorship W4319598766A5010238073 @default.
• W4319598766 hasAuthorship W4319598766A5024208145 @default.
• W4319598766 hasAuthorship W4319598766A5026213634 @default.
• W4319598766 hasAuthorship W4319598766A5039786650 @default.
• W4319598766 hasAuthorship W4319598766A5063965056 @default.
• W4319598766 hasAuthorship W4319598766A5075256301 @default.
• W4319598766 hasAuthorship W4319598766A5077353181 @default.
• W4319598766 hasAuthorship W4319598766A5077703699 @default.
• W4319598766 hasBestOaLocation W43195987661 @default.
• W4319598766 hasConcept C105795698 @default.
• W4319598766 hasConcept C121608353 @default.
• W4319598766 hasConcept C122048520 @default.
• W4319598766 hasConcept C126322002 @default.
• W4319598766 hasConcept C126894567 @default.
• W4319598766 hasConcept C151956035 @default.
• W4319598766 hasConcept C156957248 @default.
• W4319598766 hasConcept C2776235491 @default.
• W4319598766 hasConcept C2776547966 @default.
• W4319598766 hasConcept C2779478474 @default.
• W4319598766 hasConcept C2780192828 @default.
• W4319598766 hasConcept C2780221984 @default.
• W4319598766 hasConcept C2781217009 @default.
• W4319598766 hasConcept C29456083 @default.
• W4319598766 hasConcept C33923547 @default.
• W4319598766 hasConcept C44249647 @default.
• W4319598766 hasConcept C58471807 @default.
• W4319598766 hasConcept C71924100 @default.
• W4319598766 hasConceptScore W4319598766C105795698 @default.
• W4319598766 hasConceptScore W4319598766C121608353 @default.
• W4319598766 hasConceptScore W4319598766C122048520 @default.
• W4319598766 hasConceptScore W4319598766C126322002 @default.
• W4319598766 hasConceptScore W4319598766C126894567 @default.
• W4319598766 hasConceptScore W4319598766C151956035 @default.
• W4319598766 hasConceptScore W4319598766C156957248 @default.
• W4319598766 hasConceptScore W4319598766C2776235491 @default.
• W4319598766 hasConceptScore W4319598766C2776547966 @default.
• W4319598766 hasConceptScore W4319598766C2779478474 @default.
• W4319598766 hasConceptScore W4319598766C2780192828 @default.
• W4319598766 hasConceptScore W4319598766C2780221984 @default.
• W4319598766 hasConceptScore W4319598766C2781217009 @default.
• W4319598766 hasConceptScore W4319598766C29456083 @default.
• W4319598766 hasConceptScore W4319598766C33923547 @default.
• W4319598766 hasConceptScore W4319598766C44249647 @default.
• W4319598766 hasConceptScore W4319598766C58471807 @default.
• W4319598766 hasConceptScore W4319598766C71924100 @default.
• W4319598766 hasFunder F4320321001 @default.
• W4319598766 hasIssue "4" @default.
• W4319598766 hasLocation W43195987661 @default.
• W4319598766 hasLocation W43195987662 @default.
• W4319598766 hasLocation W43195987663 @default.

• next