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• W4319599916 abstract "Sociocultural attitudes towards cannabis legalization contribute to the common misconception that it is a relatively safe drug and its use during pregnancy poses no risk to the fetus. However, longitudinal studies demonstrate that maternal cannabis exposure results in adverse outcomes in the offspring, with a heightened risk for developing psychopathology. One of the most reported psychiatric outcomes is the proneness to psychotic-like experiences during childhood. How exposure to cannabis during gestation increases psychosis susceptibility in children and adolescents remains elusive. Preclinical research has indicated that in utero exposure to the major psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), deranges brain developmental trajectories towards vulnerable psychotic-like endophenotypes later in life. Here, we present how prenatal THC exposure (PCE) deregulates mesolimbic dopamine development predisposing the offspring to schizophrenia-relevant phenotypes, exclusively when exposed to environmental challenges, such as stress or THC. Detrimental effects of PCE are sex-specific because female offspring do not display psychotic-like outcomes upon exposure to these challenges. Moreover, we present how pregnenolone, a neurosteroid that showed beneficial properties on the effects elicited by cannabis intoxication, normalizes mesolimbic dopamine function and rescues psychotic-like phenotypes. We, therefore, suggest this neurosteroid as a safe disease-modifying aid to prevent the onset of psychoses in vulnerable individuals. Our findings corroborate clinical evidence and highlight the relevance of early diagnostic screening and preventative strategies for young individuals at risk for mental diseases, such as male PCE offspring." @default.
• W4319599916 created "2023-02-09" @default.
• W4319599916 creator A5031087600 @default.
• W4319599916 creator A5045189209 @default.
• W4319599916 date "2023-02-01" @default.
• W4319599916 modified "2023-09-25" @default.
• W4319599916 title "Sex‐specific susceptibility to psychotic‐like states provoked by prenatal <scp>THC</scp> exposure: Reversal by pregnenolone" @default.
• W4319599916 cites W1271082088 @default.
• W4319599916 cites W129069614 @default.
• W4319599916 cites W1550399699 @default.
• W4319599916 cites W1571533074 @default.
• W4319599916 cites W1581688434 @default.
• W4319599916 cites W1606456241 @default.
• W4319599916 cites W1877398506 @default.
• W4319599916 cites W1886084954 @default.
• W4319599916 cites W1934223132 @default.
• W4319599916 cites W1966052367 @default.
• W4319599916 cites W1966135255 @default.
• W4319599916 cites W1968524760 @default.
• W4319599916 cites W1971126815 @default.
• W4319599916 cites W1972048366 @default.
• W4319599916 cites W1973000601 @default.
• W4319599916 cites W1973947372 @default.
• W4319599916 cites W1975682905 @default.
• W4319599916 cites W1985057601 @default.
• W4319599916 cites W1985710182 @default.
• W4319599916 cites W1987034948 @default.
• W4319599916 cites W1987492515 @default.
• W4319599916 cites W1990267093 @default.
• W4319599916 cites W1990352228 @default.
• W4319599916 cites W1991374521 @default.
• W4319599916 cites W1993606937 @default.
• W4319599916 cites W1994072573 @default.
• W4319599916 cites W1995015234 @default.
• W4319599916 cites W1995629458 @default.
• W4319599916 cites W1998685086 @default.
• W4319599916 cites W1999328412 @default.
• W4319599916 cites W2001113734 @default.
• W4319599916 cites W2014736791 @default.
• W4319599916 cites W2015034605 @default.
• W4319599916 cites W2018616074 @default.
• W4319599916 cites W2020787068 @default.
• W4319599916 cites W2022258955 @default.
• W4319599916 cites W2025899299 @default.
• W4319599916 cites W2026301590 @default.
• W4319599916 cites W2026617358 @default.
• W4319599916 cites W2027461043 @default.
• W4319599916 cites W2032359153 @default.
• W4319599916 cites W2038900203 @default.
• W4319599916 cites W2040397135 @default.
• W4319599916 cites W2042676846 @default.
• W4319599916 cites W2042789109 @default.
• W4319599916 cites W2045841512 @default.
• W4319599916 cites W2046020706 @default.
• W4319599916 cites W2046384909 @default.
• W4319599916 cites W2048034622 @default.
• W4319599916 cites W2048397554 @default.
• W4319599916 cites W2051746299 @default.
• W4319599916 cites W2052578687 @default.
• W4319599916 cites W2060647422 @default.
• W4319599916 cites W2062472783 @default.
• W4319599916 cites W2063802361 @default.
• W4319599916 cites W2065339664 @default.
• W4319599916 cites W2066589616 @default.
• W4319599916 cites W2071227017 @default.
• W4319599916 cites W2075526804 @default.
• W4319599916 cites W2077822166 @default.
• W4319599916 cites W2079274472 @default.
• W4319599916 cites W2080194097 @default.
• W4319599916 cites W2082722104 @default.
• W4319599916 cites W2083446020 @default.
• W4319599916 cites W2083562313 @default.
• W4319599916 cites W2084248175 @default.
• W4319599916 cites W2086061356 @default.
• W4319599916 cites W2086884830 @default.
• W4319599916 cites W2087495709 @default.
• W4319599916 cites W2089108699 @default.
• W4319599916 cites W2089114713 @default.
• W4319599916 cites W2090979638 @default.
• W4319599916 cites W2092035803 @default.
• W4319599916 cites W2093339161 @default.
• W4319599916 cites W2093733740 @default.
• W4319599916 cites W2095549609 @default.
• W4319599916 cites W2097759310 @default.
• W4319599916 cites W2100751263 @default.
• W4319599916 cites W2115537559 @default.
• W4319599916 cites W2119181160 @default.
• W4319599916 cites W2127993528 @default.
• W4319599916 cites W2133067994 @default.
• W4319599916 cites W2134882014 @default.
• W4319599916 cites W2140123938 @default.
• W4319599916 cites W2142087193 @default.
• W4319599916 cites W2144471602 @default.
• W4319599916 cites W2145602532 @default.
• W4319599916 cites W2155117030 @default.
• W4319599916 cites W2155899403 @default.
• W4319599916 cites W2161482219 @default.
• W4319599916 cites W2162105640 @default.
• W4319599916 cites W2168201535 @default.
• W4319599916 cites W2170219130 @default.

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