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• W4319603025 abstract "Genome-scale analyses have revealed many transcription factor binding sites within, rather than upstream of genes, raising questions as to the function of these binding sites. Here, we use complementary approaches to map the regulon of the Escherichia coli transcription factor PhoB, a response regulator that controls transcription of genes involved in phosphate homeostasis. Strikingly, the majority of PhoB binding sites are located within genes, but these intragenic sites are not associated with detectable transcription regulation and are not evolutionarily conserved. Many intragenic PhoB sites are located in regions bound by H-NS, likely due to shared sequence preferences of PhoB and H-NS. However, these PhoB binding sites are not associated with transcription regulation even in the absence of H-NS. We propose that for many transcription factors, including PhoB, binding sites not associated with promoter sequences are transcriptionally inert, and hence are tolerated as genomic noise.Recent studies have revealed large numbers of transcription factor binding sites within the genes of bacteria. The function, if any, of the vast majority of these binding sites has not been investigated. Here, we map the binding of the transcription factor PhoB across the Escherichia coli genome, revealing that the majority of PhoB binding sites are within genes. We show that PhoB binding sites within genes are not associated with regulation of the overlapping genes. Indeed, our data suggest that bacteria tolerate the presence of large numbers of non-regulatory, intragenic binding sites for transcription factors, and that these binding sites are not under selective pressure." @default.
• W4319603025 created "2023-02-09" @default.
• W4319603025 creator A5002410339 @default.
• W4319603025 creator A5006491506 @default.
• W4319603025 creator A5013318672 @default.
• W4319603025 creator A5027071969 @default.
• W4319603025 creator A5057105462 @default.
• W4319603025 date "2023-02-07" @default.
• W4319603025 modified "2023-09-26" @default.
• W4319603025 title "Genome-wide mapping of the<i>Escherichia coli</i>PhoB regulon reveals many transcriptionally inert, intragenic binding sites" @default.
• W4319603025 cites W1552545164 @default.
• W4319603025 cites W1561074056 @default.
• W4319603025 cites W1580258518 @default.
• W4319603025 cites W1592870802 @default.
• W4319603025 cites W1610001324 @default.
• W4319603025 cites W1627927614 @default.
• W4319603025 cites W1665603416 @default.
• W4319603025 cites W1781531090 @default.
• W4319603025 cites W1786268878 @default.
• W4319603025 cites W1789315565 @default.
• W4319603025 cites W1964366295 @default.
• W4319603025 cites W1971023242 @default.
• W4319603025 cites W1975415672 @default.
• W4319603025 cites W1976522578 @default.
• W4319603025 cites W1976558921 @default.
• W4319603025 cites W1985932393 @default.
• W4319603025 cites W1986917466 @default.
• W4319603025 cites W1991640026 @default.
• W4319603025 cites W1995018310 @default.
• W4319603025 cites W2003014014 @default.
• W4319603025 cites W2005685856 @default.
• W4319603025 cites W2006113918 @default.
• W4319603025 cites W2006616848 @default.
• W4319603025 cites W2017140888 @default.
• W4319603025 cites W2021541861 @default.
• W4319603025 cites W2029104000 @default.
• W4319603025 cites W2031502293 @default.
• W4319603025 cites W2031859095 @default.
• W4319603025 cites W2039920423 @default.
• W4319603025 cites W2040694642 @default.
• W4319603025 cites W2043373917 @default.
• W4319603025 cites W2053712365 @default.
• W4319603025 cites W2060095084 @default.
• W4319603025 cites W2061120858 @default.
• W4319603025 cites W2062640511 @default.
• W4319603025 cites W2063570170 @default.
• W4319603025 cites W2066267034 @default.
• W4319603025 cites W2075709402 @default.
• W4319603025 cites W2079585735 @default.
• W4319603025 cites W2084026584 @default.
• W4319603025 cites W2090672353 @default.
• W4319603025 cites W2096047458 @default.
• W4319603025 cites W2097026233 @default.
• W4319603025 cites W2103441770 @default.
• W4319603025 cites W2111967267 @default.
• W4319603025 cites W2113843263 @default.
• W4319603025 cites W2116137883 @default.
• W4319603025 cites W2122126036 @default.
• W4319603025 cites W2124080033 @default.
• W4319603025 cites W2129149800 @default.
• W4319603025 cites W2130854451 @default.
• W4319603025 cites W2131478115 @default.
• W4319603025 cites W2132829654 @default.
• W4319603025 cites W2133276616 @default.
• W4319603025 cites W2134153749 @default.
• W4319603025 cites W2137390416 @default.
• W4319603025 cites W2138922826 @default.
• W4319603025 cites W2140952049 @default.
• W4319603025 cites W2148749184 @default.
• W4319603025 cites W2153695031 @default.
• W4319603025 cites W2157009395 @default.
• W4319603025 cites W2157952888 @default.
• W4319603025 cites W2159177223 @default.
• W4319603025 cites W2160084442 @default.
• W4319603025 cites W2162171603 @default.
• W4319603025 cites W2167788763 @default.
• W4319603025 cites W2168215521 @default.
• W4319603025 cites W2179438025 @default.
• W4319603025 cites W2189955651 @default.
• W4319603025 cites W2252781147 @default.
• W4319603025 cites W2414288394 @default.
• W4319603025 cites W2470098202 @default.
• W4319603025 cites W2515068008 @default.
• W4319603025 cites W2516060948 @default.
• W4319603025 cites W2523015162 @default.
• W4319603025 cites W2552984535 @default.
• W4319603025 cites W2558879079 @default.
• W4319603025 cites W2568345024 @default.
• W4319603025 cites W2765289022 @default.
• W4319603025 cites W2890535935 @default.
• W4319603025 cites W2892173484 @default.
• W4319603025 cites W2917207851 @default.
• W4319603025 cites W2923454569 @default.
• W4319603025 cites W2936521062 @default.
• W4319603025 cites W2949344431 @default.
• W4319603025 cites W2952217624 @default.
• W4319603025 cites W2972428201 @default.
• W4319603025 cites W4229769694 @default.
• W4319603025 cites W4315489568 @default.
• W4319603025 cites W77167132 @default.

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