Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319603169> ?p ?o ?g. }
- W4319603169 endingPage "135114" @default.
- W4319603169 startingPage "135114" @default.
- W4319603169 abstract "In order to develop drugs against cancer, which is one of the deadliest diseases in the world, hybridizing structures with known anticancer activity can provide a dual activity for the treatment of cancer cases. For this purpose, a series of novel hybrid compounds combining lonidamine and 7-hydroxy-4-methylcoumarin via different linker modifications have been synthesized in this study. The chemical structures of the novel compound were elucidated with 1H and 13C NMR and mass spectrometry (HRMS) methods. All the synthesized compounds were screened for anticancer activity against MCF-7 and A549 cells. Among them, compound 2 appeared to be the most potent compound on MCF-7 lines; and IC50 dose was determined as 33.12 µM. IC50 of Compound 6 was determined as 139.6 µM for A549 cells. Considering anticancer activity studies, compounds 2 and 6 have potential to lead to the development of novel hybrid compounds for cancer therapy. Further studies to identify mechanistic explanations of the bioactivity of these molecules are ongoing and will be reported in due course." @default.
- W4319603169 created "2023-02-09" @default.
- W4319603169 creator A5013905468 @default.
- W4319603169 creator A5013979957 @default.
- W4319603169 creator A5064041308 @default.
- W4319603169 creator A5065618675 @default.
- W4319603169 creator A5089434392 @default.
- W4319603169 date "2023-06-01" @default.
- W4319603169 modified "2023-10-11" @default.
- W4319603169 title "Synthesis of Novel Hybrid Lonidamine-Coumarin Derivatives and Their Anticancer Activities" @default.
- W4319603169 cites W1809052990 @default.
- W4319603169 cites W1972132259 @default.
- W4319603169 cites W1973345865 @default.
- W4319603169 cites W1993497779 @default.
- W4319603169 cites W2004256081 @default.
- W4319603169 cites W2007887352 @default.
- W4319603169 cites W2017139887 @default.
- W4319603169 cites W2020251956 @default.
- W4319603169 cites W2030023798 @default.
- W4319603169 cites W2036608921 @default.
- W4319603169 cites W2043612028 @default.
- W4319603169 cites W2045341540 @default.
- W4319603169 cites W2053452104 @default.
- W4319603169 cites W2056942164 @default.
- W4319603169 cites W2058384902 @default.
- W4319603169 cites W2093278528 @default.
- W4319603169 cites W2101680235 @default.
- W4319603169 cites W2105668062 @default.
- W4319603169 cites W2113712041 @default.
- W4319603169 cites W2113808782 @default.
- W4319603169 cites W2120773280 @default.
- W4319603169 cites W2150465569 @default.
- W4319603169 cites W2221923578 @default.
- W4319603169 cites W2251721496 @default.
- W4319603169 cites W2296500820 @default.
- W4319603169 cites W2379628571 @default.
- W4319603169 cites W2414384984 @default.
- W4319603169 cites W2483796603 @default.
- W4319603169 cites W2484368597 @default.
- W4319603169 cites W2513919024 @default.
- W4319603169 cites W2531607465 @default.
- W4319603169 cites W2562144074 @default.
- W4319603169 cites W2565269239 @default.
- W4319603169 cites W2593136999 @default.
- W4319603169 cites W2593436234 @default.
- W4319603169 cites W2730391841 @default.
- W4319603169 cites W2770021551 @default.
- W4319603169 cites W2774471029 @default.
- W4319603169 cites W2781767224 @default.
- W4319603169 cites W2900384163 @default.
- W4319603169 cites W2910550373 @default.
- W4319603169 cites W2945385843 @default.
- W4319603169 cites W2946532082 @default.
- W4319603169 cites W2994712462 @default.
- W4319603169 cites W3002674380 @default.
- W4319603169 cites W3086596505 @default.
- W4319603169 cites W3095128865 @default.
- W4319603169 cites W3105923034 @default.
- W4319603169 cites W3107668311 @default.
- W4319603169 cites W3153014866 @default.
- W4319603169 cites W3159751369 @default.
- W4319603169 cites W3201504425 @default.
- W4319603169 cites W4206508957 @default.
- W4319603169 cites W4213075752 @default.
- W4319603169 cites W594050491 @default.
- W4319603169 doi "https://doi.org/10.1016/j.molstruc.2023.135114" @default.
- W4319603169 hasPublicationYear "2023" @default.
- W4319603169 type Work @default.
- W4319603169 citedByCount "0" @default.
- W4319603169 crossrefType "journal-article" @default.
- W4319603169 hasAuthorship W4319603169A5013905468 @default.
- W4319603169 hasAuthorship W4319603169A5013979957 @default.
- W4319603169 hasAuthorship W4319603169A5064041308 @default.
- W4319603169 hasAuthorship W4319603169A5065618675 @default.
- W4319603169 hasAuthorship W4319603169A5089434392 @default.
- W4319603169 hasConcept C111919701 @default.
- W4319603169 hasConcept C178790620 @default.
- W4319603169 hasConcept C185592680 @default.
- W4319603169 hasConcept C202751555 @default.
- W4319603169 hasConcept C21951064 @default.
- W4319603169 hasConcept C2777752112 @default.
- W4319603169 hasConcept C2780557392 @default.
- W4319603169 hasConcept C2781338262 @default.
- W4319603169 hasConcept C41008148 @default.
- W4319603169 hasConcept C55493867 @default.
- W4319603169 hasConcept C71240020 @default.
- W4319603169 hasConceptScore W4319603169C111919701 @default.
- W4319603169 hasConceptScore W4319603169C178790620 @default.
- W4319603169 hasConceptScore W4319603169C185592680 @default.
- W4319603169 hasConceptScore W4319603169C202751555 @default.
- W4319603169 hasConceptScore W4319603169C21951064 @default.
- W4319603169 hasConceptScore W4319603169C2777752112 @default.
- W4319603169 hasConceptScore W4319603169C2780557392 @default.
- W4319603169 hasConceptScore W4319603169C2781338262 @default.
- W4319603169 hasConceptScore W4319603169C41008148 @default.
- W4319603169 hasConceptScore W4319603169C55493867 @default.
- W4319603169 hasConceptScore W4319603169C71240020 @default.
- W4319603169 hasLocation W43196031691 @default.