Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319655802> ?p ?o ?g. }
- W4319655802 endingPage "844" @default.
- W4319655802 startingPage "832" @default.
- W4319655802 abstract "Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are mainly composed of alpha-synuclein fibrils. Alpha-synuclein plays a vital role in the neuroinflammation mediated by the nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome in PD. A better understanding of the NLRP3 inflammasome-mediated neuroinflammation and the related mitochondrial impairment during PD progression may facilitate the development of promising therapies for PD. This review focuses on the molecular mechanisms underlying NLRP3 inflammasome activation, comprising priming and protein complex assembly, as well as the role of mitochondrial impairment and its subsequent inflammatory effects on the progression of neurodegeneration in PD. In addition, the therapeutic strategies targeting the NLRP3 inflammasome for PD treatment are discussed, including the inhibitors of NLRP3 inflammatory pathways, mitochondria-focused treatments, microRNAs, and other therapeutic compounds." @default.
- W4319655802 created "2023-02-10" @default.
- W4319655802 creator A5007172109 @default.
- W4319655802 creator A5020478356 @default.
- W4319655802 date "2023-02-09" @default.
- W4319655802 modified "2023-09-26" @default.
- W4319655802 title "NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson’s Disease" @default.
- W4319655802 cites W1232419225 @default.
- W4319655802 cites W1520955829 @default.
- W4319655802 cites W1563590122 @default.
- W4319655802 cites W1574200406 @default.
- W4319655802 cites W1861790843 @default.
- W4319655802 cites W1980792888 @default.
- W4319655802 cites W1984520240 @default.
- W4319655802 cites W1985538633 @default.
- W4319655802 cites W2006696253 @default.
- W4319655802 cites W2015283405 @default.
- W4319655802 cites W2039276913 @default.
- W4319655802 cites W2062646625 @default.
- W4319655802 cites W2070300008 @default.
- W4319655802 cites W2079882002 @default.
- W4319655802 cites W2084158898 @default.
- W4319655802 cites W2089503694 @default.
- W4319655802 cites W2108527091 @default.
- W4319655802 cites W2110374590 @default.
- W4319655802 cites W2117175402 @default.
- W4319655802 cites W2119765154 @default.
- W4319655802 cites W2130696471 @default.
- W4319655802 cites W2131415852 @default.
- W4319655802 cites W2140637559 @default.
- W4319655802 cites W2141976392 @default.
- W4319655802 cites W2158472906 @default.
- W4319655802 cites W2159754384 @default.
- W4319655802 cites W2170936782 @default.
- W4319655802 cites W2254807163 @default.
- W4319655802 cites W2260110125 @default.
- W4319655802 cites W2289901196 @default.
- W4319655802 cites W2313775426 @default.
- W4319655802 cites W2319054200 @default.
- W4319655802 cites W2340005882 @default.
- W4319655802 cites W2340990989 @default.
- W4319655802 cites W2419297424 @default.
- W4319655802 cites W2464176930 @default.
- W4319655802 cites W2469470316 @default.
- W4319655802 cites W2482486185 @default.
- W4319655802 cites W2487889682 @default.
- W4319655802 cites W2503377259 @default.
- W4319655802 cites W2510071623 @default.
- W4319655802 cites W2564122215 @default.
- W4319655802 cites W2566687904 @default.
- W4319655802 cites W2592822773 @default.
- W4319655802 cites W2608687752 @default.
- W4319655802 cites W2627048017 @default.
- W4319655802 cites W2738996050 @default.
- W4319655802 cites W2751735330 @default.
- W4319655802 cites W2758797028 @default.
- W4319655802 cites W2761027295 @default.
- W4319655802 cites W2776048975 @default.
- W4319655802 cites W2782357499 @default.
- W4319655802 cites W2804970493 @default.
- W4319655802 cites W2806727408 @default.
- W4319655802 cites W2884212992 @default.
- W4319655802 cites W2890204725 @default.
- W4319655802 cites W2890670389 @default.
- W4319655802 cites W2896513955 @default.
- W4319655802 cites W2907424910 @default.
- W4319655802 cites W2909369603 @default.
- W4319655802 cites W2941630117 @default.
- W4319655802 cites W2941649336 @default.
- W4319655802 cites W2942726688 @default.
- W4319655802 cites W2943293743 @default.
- W4319655802 cites W2953518553 @default.
- W4319655802 cites W2954319214 @default.
- W4319655802 cites W2954782052 @default.
- W4319655802 cites W2966760137 @default.
- W4319655802 cites W2979201720 @default.
- W4319655802 cites W2982503871 @default.
- W4319655802 cites W2990948783 @default.
- W4319655802 cites W2991193771 @default.
- W4319655802 cites W2993255052 @default.
- W4319655802 cites W2993839097 @default.
- W4319655802 cites W2999498841 @default.
- W4319655802 cites W3000746362 @default.
- W4319655802 cites W3007065131 @default.
- W4319655802 cites W3007109891 @default.
- W4319655802 cites W3012129826 @default.
- W4319655802 cites W3015393370 @default.
- W4319655802 cites W3015776834 @default.
- W4319655802 cites W3016614566 @default.
- W4319655802 cites W3018180730 @default.
- W4319655802 cites W3020906235 @default.
- W4319655802 cites W3040503808 @default.
- W4319655802 cites W3042580583 @default.
- W4319655802 cites W3044456561 @default.
- W4319655802 cites W3044492976 @default.
- W4319655802 cites W3047400254 @default.
- W4319655802 cites W3086700629 @default.
- W4319655802 cites W3087243951 @default.