FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319656095> ?p ?o ?g. }

• W4319656095 endingPage "122422" @default.
• W4319656095 startingPage "122422" @default.
• W4319656095 abstract "Despite universal endoscopic screening, early detection of gastric cancer is challenging, led researchers to seek for a novel approach in detecting. Raman spectroscopy measurements as a fingerprint of biochemical structure, enable accurate prediction of gastric lesions non-destructively. This study aimed to evaluate the diagnostic power of Raman spectroscopy in early gastric cancer (EGC), and reveal dynamic biomolecular changes in vitro from normal to EGC. To clarify the biochemical alterations in Correa's cascade, Raman spectra of human normal gastric mucosa, intestinal metaplasia, dysplasia, and adenocarcinoma were compared at tissue and cellular levels based on a self-developed data processing program. For effectively identify EGC, Raman spectroscopy was used combined with multiple machine learning methods, including partial least-squares discriminant analysis (PLS-DA), support vector machine (SVM), and convolutional neural network (CNN) with leave-one-out (LOO) cross validation. A total of 450 Raman spectra were investigated in this study. The upregulation of νsym(O-P-O) backbone (p < 0.001) was identified as a favorable factor for the diagnosis of EGC, the area under the ROC curve (AUC) was up to 0.918. In addition, higher levels of lactic acid (p < 0.001), lipids (p < 0.001), phenylalanine (p = 0.002), and carotenoids (p < 0.001) were detected in EGC. Multivariate machine learning methods for diagnosis of EGC based on Raman spectroscopy, the sensitivity, specificity, accuracy, and AUC were 91.0%, 100%, 94.8%, and 95.8% for SVM, and 84.8%, 92.0%, 88.8%, and 95.5% for CNN, respectively. Raman spectroscopy can be used as a powerful tool for detecting EGC while elucidating biomolecular dynamics in tumorigenesis. (Chictr.org.cn, ChiCTR2200060720.)." @default.
• W4319656095 created "2023-02-10" @default.
• W4319656095 creator A5006822602 @default.
• W4319656095 creator A5008260782 @default.
• W4319656095 creator A5026232296 @default.
• W4319656095 creator A5034227844 @default.
• W4319656095 creator A5037814026 @default.
• W4319656095 creator A5050803462 @default.
• W4319656095 creator A5054097926 @default.
• W4319656095 creator A5063880073 @default.
• W4319656095 creator A5065753157 @default.
• W4319656095 creator A5069881431 @default.
• W4319656095 creator A5070046647 @default.
• W4319656095 creator A5080614500 @default.
• W4319656095 creator A5082549798 @default.
• W4319656095 creator A5082828861 @default.
• W4319656095 creator A5087528936 @default.
• W4319656095 creator A5091157253 @default.
• W4319656095 date "2023-05-01" @default.
• W4319656095 modified "2023-10-05" @default.
• W4319656095 title "A novel detection technology for early gastric cancer based on Raman spectroscopy" @default.
• W4319656095 cites W1978717121 @default.
• W4319656095 cites W1985513966 @default.
• W4319656095 cites W2004045970 @default.
• W4319656095 cites W2012531137 @default.
• W4319656095 cites W2028731754 @default.
• W4319656095 cites W2048854233 @default.
• W4319656095 cites W2060398669 @default.
• W4319656095 cites W2072443063 @default.
• W4319656095 cites W2072451938 @default.
• W4319656095 cites W2072974951 @default.
• W4319656095 cites W2076422780 @default.
• W4319656095 cites W2086728248 @default.
• W4319656095 cites W2090857330 @default.
• W4319656095 cites W2098108268 @default.
• W4319656095 cites W2104157882 @default.
• W4319656095 cites W2114747112 @default.
• W4319656095 cites W2118107482 @default.
• W4319656095 cites W2143363498 @default.
• W4319656095 cites W2145957203 @default.
• W4319656095 cites W2148051205 @default.
• W4319656095 cites W2162295781 @default.
• W4319656095 cites W2163503448 @default.
• W4319656095 cites W2167795547 @default.
• W4319656095 cites W2326263080 @default.
• W4319656095 cites W2548475758 @default.
• W4319656095 cites W2606140368 @default.
• W4319656095 cites W2613787918 @default.
• W4319656095 cites W2899853775 @default.
• W4319656095 cites W2942165081 @default.
• W4319656095 cites W3024932144 @default.
• W4319656095 cites W3080865242 @default.
• W4319656095 cites W3112561157 @default.
• W4319656095 cites W3124347854 @default.
• W4319656095 cites W3204070587 @default.
• W4319656095 cites W4210478337 @default.
• W4319656095 cites W4238768614 @default.
• W4319656095 cites W4285392824 @default.
• W4319656095 doi "https://doi.org/10.1016/j.saa.2023.122422" @default.
• W4319656095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36753864" @default.
• W4319656095 hasPublicationYear "2023" @default.
• W4319656095 type Work @default.
• W4319656095 citedByCount "0" @default.
• W4319656095 crossrefType "journal-article" @default.
• W4319656095 hasAuthorship W4319656095A5006822602 @default.
• W4319656095 hasAuthorship W4319656095A5008260782 @default.
• W4319656095 hasAuthorship W4319656095A5026232296 @default.
• W4319656095 hasAuthorship W4319656095A5034227844 @default.
• W4319656095 hasAuthorship W4319656095A5037814026 @default.
• W4319656095 hasAuthorship W4319656095A5050803462 @default.
• W4319656095 hasAuthorship W4319656095A5054097926 @default.
• W4319656095 hasAuthorship W4319656095A5063880073 @default.
• W4319656095 hasAuthorship W4319656095A5065753157 @default.
• W4319656095 hasAuthorship W4319656095A5069881431 @default.
• W4319656095 hasAuthorship W4319656095A5070046647 @default.
• W4319656095 hasAuthorship W4319656095A5080614500 @default.
• W4319656095 hasAuthorship W4319656095A5082549798 @default.
• W4319656095 hasAuthorship W4319656095A5082828861 @default.
• W4319656095 hasAuthorship W4319656095A5087528936 @default.
• W4319656095 hasAuthorship W4319656095A5091157253 @default.
• W4319656095 hasBestOaLocation W43196560951 @default.
• W4319656095 hasConcept C113196181 @default.
• W4319656095 hasConcept C120665830 @default.
• W4319656095 hasConcept C121332964 @default.
• W4319656095 hasConcept C121608353 @default.
• W4319656095 hasConcept C126322002 @default.
• W4319656095 hasConcept C151304367 @default.
• W4319656095 hasConcept C154945302 @default.
• W4319656095 hasConcept C185592680 @default.
• W4319656095 hasConcept C40003534 @default.
• W4319656095 hasConcept C41008148 @default.
• W4319656095 hasConcept C43617362 @default.
• W4319656095 hasConcept C71924100 @default.
• W4319656095 hasConcept C90924648 @default.
• W4319656095 hasConceptScore W4319656095C113196181 @default.
• W4319656095 hasConceptScore W4319656095C120665830 @default.
• W4319656095 hasConceptScore W4319656095C121332964 @default.
• W4319656095 hasConceptScore W4319656095C121608353 @default.

• next