Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319656491> ?p ?o ?g. }
- W4319656491 abstract "Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury. Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes. Here, we found that more macrophages were activated toward the M2 subtype in keloid dermis when compared with normal dermis. Western blotting revealed that the level of phosphorylated STAT6 (p-STAT6), a known inducer of M2 polarization, was higher in keloid fibroblasts as opposed to fibroblasts from normal dermis. Moreover, keloid fibrosis was shown to be positively correlated with the level of p-STAT6. Further, we identified downregulation of IL-13RA2, a decoy receptor for IL-13, in keloid fibroblasts compared with fibroblasts from normal dermis. Ectopic expression of IL-13RA2 in keloid fibroblasts resulted in inhibition of STAT6 phosphorylation, cell proliferation, migration, invasion, extracellular matrix secretion, and myofibroblast marker expression, as well as an increase in apoptosis. Consistently, knockdown of IL-13RA2 in normal fibroblasts induced a keloidal status. Furthermore, both in vitro application and intratumoral injection of p-STAT6 inhibitor AS1517499 in a patient-derived xenograft keloid-implantation mouse model resulted in proliferation inhibition and tissue necrosis, apoptosis, and myofibroblast marker reduction. Collectively, this study elucidates the key role of IL-13RA2 in keloid pathology and inspires further translational research of keloid treatment concerning JAK/STAT6 inhibition." @default.
- W4319656491 created "2023-02-10" @default.
- W4319656491 creator A5008592425 @default.
- W4319656491 creator A5023737646 @default.
- W4319656491 creator A5036358906 @default.
- W4319656491 creator A5047358306 @default.
- W4319656491 creator A5047886846 @default.
- W4319656491 creator A5048419560 @default.
- W4319656491 creator A5049387665 @default.
- W4319656491 creator A5051758870 @default.
- W4319656491 creator A5053348661 @default.
- W4319656491 creator A5058733242 @default.
- W4319656491 creator A5075278320 @default.
- W4319656491 date "2023-03-22" @default.
- W4319656491 modified "2023-10-16" @default.
- W4319656491 title "IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation" @default.
- W4319656491 cites W1983357763 @default.
- W4319656491 cites W1989676489 @default.
- W4319656491 cites W2026813843 @default.
- W4319656491 cites W2028937551 @default.
- W4319656491 cites W2043449217 @default.
- W4319656491 cites W2045142779 @default.
- W4319656491 cites W2085293124 @default.
- W4319656491 cites W2118654016 @default.
- W4319656491 cites W2125268957 @default.
- W4319656491 cites W2333068168 @default.
- W4319656491 cites W2336980926 @default.
- W4319656491 cites W2527289641 @default.
- W4319656491 cites W2568092366 @default.
- W4319656491 cites W2582273325 @default.
- W4319656491 cites W2593918601 @default.
- W4319656491 cites W2734365706 @default.
- W4319656491 cites W2767884418 @default.
- W4319656491 cites W2774171294 @default.
- W4319656491 cites W2833527792 @default.
- W4319656491 cites W2900976549 @default.
- W4319656491 cites W2902282736 @default.
- W4319656491 cites W2971635939 @default.
- W4319656491 cites W2989620718 @default.
- W4319656491 cites W2990290007 @default.
- W4319656491 cites W3008604700 @default.
- W4319656491 cites W3015143081 @default.
- W4319656491 cites W3109793392 @default.
- W4319656491 cites W3165135090 @default.
- W4319656491 cites W3170991445 @default.
- W4319656491 cites W3181626849 @default.
- W4319656491 doi "https://doi.org/10.1172/jci.insight.157091" @default.
- W4319656491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36757802" @default.
- W4319656491 hasPublicationYear "2023" @default.
- W4319656491 type Work @default.
- W4319656491 citedByCount "3" @default.
- W4319656491 countsByYear W43196564912023 @default.
- W4319656491 crossrefType "journal-article" @default.
- W4319656491 hasAuthorship W4319656491A5008592425 @default.
- W4319656491 hasAuthorship W4319656491A5023737646 @default.
- W4319656491 hasAuthorship W4319656491A5036358906 @default.
- W4319656491 hasAuthorship W4319656491A5047358306 @default.
- W4319656491 hasAuthorship W4319656491A5047886846 @default.
- W4319656491 hasAuthorship W4319656491A5048419560 @default.
- W4319656491 hasAuthorship W4319656491A5049387665 @default.
- W4319656491 hasAuthorship W4319656491A5051758870 @default.
- W4319656491 hasAuthorship W4319656491A5053348661 @default.
- W4319656491 hasAuthorship W4319656491A5058733242 @default.
- W4319656491 hasAuthorship W4319656491A5075278320 @default.
- W4319656491 hasBestOaLocation W43196564911 @default.
- W4319656491 hasConcept C104317684 @default.
- W4319656491 hasConcept C127561419 @default.
- W4319656491 hasConcept C142724271 @default.
- W4319656491 hasConcept C145430368 @default.
- W4319656491 hasConcept C185592680 @default.
- W4319656491 hasConcept C189165786 @default.
- W4319656491 hasConcept C191732599 @default.
- W4319656491 hasConcept C202751555 @default.
- W4319656491 hasConcept C203014093 @default.
- W4319656491 hasConcept C207865475 @default.
- W4319656491 hasConcept C2777538232 @default.
- W4319656491 hasConcept C2777624698 @default.
- W4319656491 hasConcept C2778690821 @default.
- W4319656491 hasConcept C2780381497 @default.
- W4319656491 hasConcept C2780559512 @default.
- W4319656491 hasConcept C502942594 @default.
- W4319656491 hasConcept C55493867 @default.
- W4319656491 hasConcept C71924100 @default.
- W4319656491 hasConcept C86803240 @default.
- W4319656491 hasConcept C95444343 @default.
- W4319656491 hasConceptScore W4319656491C104317684 @default.
- W4319656491 hasConceptScore W4319656491C127561419 @default.
- W4319656491 hasConceptScore W4319656491C142724271 @default.
- W4319656491 hasConceptScore W4319656491C145430368 @default.
- W4319656491 hasConceptScore W4319656491C185592680 @default.
- W4319656491 hasConceptScore W4319656491C189165786 @default.
- W4319656491 hasConceptScore W4319656491C191732599 @default.
- W4319656491 hasConceptScore W4319656491C202751555 @default.
- W4319656491 hasConceptScore W4319656491C203014093 @default.
- W4319656491 hasConceptScore W4319656491C207865475 @default.
- W4319656491 hasConceptScore W4319656491C2777538232 @default.
- W4319656491 hasConceptScore W4319656491C2777624698 @default.
- W4319656491 hasConceptScore W4319656491C2778690821 @default.
- W4319656491 hasConceptScore W4319656491C2780381497 @default.
- W4319656491 hasConceptScore W4319656491C2780559512 @default.