FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319656512> ?p ?o ?g. }

• W4319656512 endingPage "511" @default.
• W4319656512 startingPage "511" @default.
• W4319656512 abstract "Hypofractionated radiation therapy (RT) for prostate cancer has been associated with greater acute grade 2 gastrointestinal (GI) toxic effects compared with conventionally fractionated RT.To evaluate whether a hyaluronic acid rectal spacer could (1) improve rectal dosimetry and (2) affect acute grade 2 or higher GI toxic effects for hypofractionated RT.This randomized clinical trial was conducted from March 2020 to June 2021 among 12 centers within the US, Australia, and Spain, with a 6-month follow-up. Adult patients with biopsy-proven, T1 to T2 prostate cancer with a Gleason score 7 or less and prostate-specific antigen level of 20 ng/mL or less (to convert to μg/L, multiply by 1) were blinded to the treatment arms. Of the 260 consented patients, 201 patients (77.3%) were randomized (2:1) to the presence or absence of the spacer. Patients were stratified by intended 4-month androgen deprivation therapy use and erectile quality.For the primary outcome, we hypothesized that more than 70% of patients in the spacer group would achieve a 25% or greater reduction in the rectal volume receiving 54 Gy (V54). For the secondary outcome, we hypothesized that the spacer group would have noninferior acute (within 3 months) grade 2 or higher GI toxic effects compared with the control group, with a margin of 10%.Of the 201 randomized patients, 8 (4.0%) were Asian, 26 (12.9%) Black, 42 (20.9%) Hispanic or Latino, and 153 (76.1%) White; the mean (SD) age for the spacer group was 68.6 (7.2) years and 68.4 (7.3) years for the control group. For the primary outcome, 131 of 133 (98.5%; 95% CI, 94.7%-99.8%) patients in the spacer group experienced a 25% or greater reduction in rectum V54, which was greater than the minimally acceptable 70% (P < .001). The mean (SD) reduction was 85.0% (20.9%). For the secondary outcome, 4 of 136 patients (2.9%) in the spacer group and 9 of 65 patients (13.8%) in the control group experienced acute grade 2 or higher GI toxic effects (difference, -10.9%; 95% 1-sided upper confidence limit, -3.5; P = .01).The trial results suggest that rectal spacing with hyaluronic acid improved rectal dosimetry and reduced acute grade 2 or higher GI toxic effects. Rectal spacing should potentially be considered for minimizing the risk of acute grade 2 or higher toxic effects for hypofractionated RT.ClinicalTrials.gov Identifier: NCT04189913." @default.
• W4319656512 created "2023-02-10" @default.
• W4319656512 creator A5009377030 @default.
• W4319656512 creator A5010924839 @default.
• W4319656512 creator A5017489747 @default.
• W4319656512 creator A5022572289 @default.
• W4319656512 creator A5026191288 @default.
• W4319656512 creator A5031167219 @default.
• W4319656512 creator A5034131964 @default.
• W4319656512 creator A5034760584 @default.
• W4319656512 creator A5040900375 @default.
• W4319656512 creator A5041615709 @default.
• W4319656512 creator A5044915469 @default.
• W4319656512 creator A5053960294 @default.
• W4319656512 creator A5058337410 @default.
• W4319656512 creator A5059255743 @default.
• W4319656512 creator A5067885700 @default.
• W4319656512 creator A5068657992 @default.
• W4319656512 creator A5071509379 @default.
• W4319656512 creator A5075740763 @default.
• W4319656512 creator A5082565755 @default.
• W4319656512 creator A5084699105 @default.
• W4319656512 creator A5084710848 @default.
• W4319656512 creator A5088518998 @default.
• W4319656512 creator A5091674984 @default.
• W4319656512 date "2023-04-01" @default.
• W4319656512 modified "2023-10-09" @default.
• W4319656512 title "Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy" @default.
• W4319656512 cites W1672942043 @default.
• W4319656512 cites W1965416391 @default.
• W4319656512 cites W1968864845 @default.
• W4319656512 cites W1974397085 @default.
• W4319656512 cites W2006344844 @default.
• W4319656512 cites W2017622807 @default.
• W4319656512 cites W2035429331 @default.
• W4319656512 cites W2037820102 @default.
• W4319656512 cites W2045136752 @default.
• W4319656512 cites W2060756054 @default.
• W4319656512 cites W2111180711 @default.
• W4319656512 cites W2216819529 @default.
• W4319656512 cites W2427000575 @default.
• W4319656512 cites W2465092116 @default.
• W4319656512 cites W2469323349 @default.
• W4319656512 cites W2528099959 @default.
• W4319656512 cites W2592338623 @default.
• W4319656512 cites W2601353955 @default.
• W4319656512 cites W2603384438 @default.
• W4319656512 cites W2736966846 @default.
• W4319656512 cites W2738966944 @default.
• W4319656512 cites W2883907672 @default.
• W4319656512 cites W3001817330 @default.
• W4319656512 cites W3093662369 @default.
• W4319656512 cites W3163179218 @default.
• W4319656512 cites W3185711521 @default.
• W4319656512 cites W3210368009 @default.
• W4319656512 cites W4283778929 @default.
• W4319656512 doi "https://doi.org/10.1001/jamaoncol.2022.7592" @default.
• W4319656512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36757690" @default.
• W4319656512 hasPublicationYear "2023" @default.
• W4319656512 type Work @default.
• W4319656512 citedByCount "10" @default.
• W4319656512 countsByYear W43196565122023 @default.
• W4319656512 crossrefType "journal-article" @default.
• W4319656512 hasAuthorship W4319656512A5009377030 @default.
• W4319656512 hasAuthorship W4319656512A5010924839 @default.
• W4319656512 hasAuthorship W4319656512A5017489747 @default.
• W4319656512 hasAuthorship W4319656512A5022572289 @default.
• W4319656512 hasAuthorship W4319656512A5026191288 @default.
• W4319656512 hasAuthorship W4319656512A5031167219 @default.
• W4319656512 hasAuthorship W4319656512A5034131964 @default.
• W4319656512 hasAuthorship W4319656512A5034760584 @default.
• W4319656512 hasAuthorship W4319656512A5040900375 @default.
• W4319656512 hasAuthorship W4319656512A5041615709 @default.
• W4319656512 hasAuthorship W4319656512A5044915469 @default.
• W4319656512 hasAuthorship W4319656512A5053960294 @default.
• W4319656512 hasAuthorship W4319656512A5058337410 @default.
• W4319656512 hasAuthorship W4319656512A5059255743 @default.
• W4319656512 hasAuthorship W4319656512A5067885700 @default.
• W4319656512 hasAuthorship W4319656512A5068657992 @default.
• W4319656512 hasAuthorship W4319656512A5071509379 @default.
• W4319656512 hasAuthorship W4319656512A5075740763 @default.
• W4319656512 hasAuthorship W4319656512A5082565755 @default.
• W4319656512 hasAuthorship W4319656512A5084699105 @default.
• W4319656512 hasAuthorship W4319656512A5084710848 @default.
• W4319656512 hasAuthorship W4319656512A5088518998 @default.
• W4319656512 hasAuthorship W4319656512A5091674984 @default.
• W4319656512 hasBestOaLocation W43196565121 @default.
• W4319656512 hasConcept C121608353 @default.
• W4319656512 hasConcept C126322002 @default.
• W4319656512 hasConcept C126894567 @default.
• W4319656512 hasConcept C141071460 @default.
• W4319656512 hasConcept C168563851 @default.
• W4319656512 hasConcept C2776235491 @default.
• W4319656512 hasConcept C2777899217 @default.
• W4319656512 hasConcept C2780192828 @default.
• W4319656512 hasConcept C509974204 @default.
• W4319656512 hasConcept C71924100 @default.
• W4319656512 hasConcept C90924648 @default.

• next