Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319659088> ?p ?o ?g. }
- W4319659088 abstract "In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in only a small percentage of patients in solid cancer. How to improve the efficiency of cancer immunotherapy is an urgent problem to be solved. As we all know, the state of the tumor microenvironment (TME) is an essential factor affecting the effectiveness of tumor immunotherapy, and the cancer-associated fibroblasts (CAFs) in TME have attracted much attention in recent years. As one of the main components of TME, CAFs interact with cancer cells and immune cells by secreting cytokines and vesicles, participating in ECM remodeling, and finally affecting the immune response process. With the in-depth study of CAFs heterogeneity, new strategies are provided for finding targets of combination immunotherapy and predicting immune efficacy. In this review, we focus on the role of CAFs in the solid cancer immune microenvironment, and then further elaborate on the potential mechanisms and pathways of CAFs influencing anti-PD-1/PD-L1 immunotherapy. In addition, we summarize the potential clinical application value of CAFs-related targets and markers in solid cancers." @default.
- W4319659088 created "2023-02-10" @default.
- W4319659088 creator A5023363049 @default.
- W4319659088 creator A5031801155 @default.
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- W4319659088 creator A5043090462 @default.
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- W4319659088 creator A5067053098 @default.
- W4319659088 creator A5079041846 @default.
- W4319659088 creator A5086664284 @default.
- W4319659088 date "2023-02-10" @default.
- W4319659088 modified "2023-10-16" @default.
- W4319659088 title "Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers" @default.
- W4319659088 cites W1480038018 @default.
- W4319659088 cites W1640854798 @default.
- W4319659088 cites W1915112013 @default.
- W4319659088 cites W1979111436 @default.
- W4319659088 cites W1983874247 @default.
- W4319659088 cites W1997944395 @default.
- W4319659088 cites W1999178796 @default.
- W4319659088 cites W2002157461 @default.
- W4319659088 cites W2002879831 @default.
- W4319659088 cites W2007606465 @default.
- W4319659088 cites W2015616022 @default.
- W4319659088 cites W2025796876 @default.
- W4319659088 cites W2041433337 @default.
- W4319659088 cites W2042699075 @default.
- W4319659088 cites W2043503111 @default.
- W4319659088 cites W2053353274 @default.
- W4319659088 cites W2059716736 @default.
- W4319659088 cites W2063310959 @default.
- W4319659088 cites W2085963386 @default.
- W4319659088 cites W2088110734 @default.
- W4319659088 cites W2093705034 @default.
- W4319659088 cites W2095695756 @default.
- W4319659088 cites W2101037339 @default.
- W4319659088 cites W2101682111 @default.
- W4319659088 cites W2102251969 @default.
- W4319659088 cites W2102498455 @default.
- W4319659088 cites W2120010406 @default.
- W4319659088 cites W2124846832 @default.
- W4319659088 cites W2131845821 @default.
- W4319659088 cites W2136280424 @default.
- W4319659088 cites W2154061152 @default.
- W4319659088 cites W2155360682 @default.
- W4319659088 cites W2160615924 @default.
- W4319659088 cites W2162204705 @default.
- W4319659088 cites W2162647235 @default.
- W4319659088 cites W2166662937 @default.
- W4319659088 cites W2169281418 @default.
- W4319659088 cites W2169491358 @default.
- W4319659088 cites W2170872089 @default.
- W4319659088 cites W2262673463 @default.
- W4319659088 cites W2277748889 @default.
- W4319659088 cites W2343063345 @default.
- W4319659088 cites W2411767313 @default.
- W4319659088 cites W2462485532 @default.
- W4319659088 cites W2572174216 @default.
- W4319659088 cites W2582671354 @default.
- W4319659088 cites W2590497374 @default.
- W4319659088 cites W2592666036 @default.
- W4319659088 cites W2594100081 @default.
- W4319659088 cites W2594615455 @default.
- W4319659088 cites W2607411382 @default.
- W4319659088 cites W2615301036 @default.
- W4319659088 cites W2617691667 @default.
- W4319659088 cites W2765354611 @default.
- W4319659088 cites W2769614741 @default.
- W4319659088 cites W2775714010 @default.
- W4319659088 cites W2783471328 @default.
- W4319659088 cites W2785803176 @default.
- W4319659088 cites W2786031287 @default.
- W4319659088 cites W2788975052 @default.
- W4319659088 cites W2789421415 @default.
- W4319659088 cites W2791017778 @default.
- W4319659088 cites W2791310865 @default.
- W4319659088 cites W2801303687 @default.
- W4319659088 cites W2802519389 @default.
- W4319659088 cites W2803210291 @default.
- W4319659088 cites W2810317548 @default.
- W4319659088 cites W2811458542 @default.
- W4319659088 cites W2887249435 @default.
- W4319659088 cites W2891041575 @default.
- W4319659088 cites W2891660187 @default.
- W4319659088 cites W2894451493 @default.
- W4319659088 cites W2899204048 @default.
- W4319659088 cites W2901515128 @default.
- W4319659088 cites W2902185751 @default.
- W4319659088 cites W2911671599 @default.
- W4319659088 cites W2911949455 @default.
- W4319659088 cites W2921032446 @default.
- W4319659088 cites W2921558231 @default.
- W4319659088 cites W2922696774 @default.
- W4319659088 cites W2929109925 @default.
- W4319659088 cites W2933419869 @default.
- W4319659088 cites W2939873510 @default.
- W4319659088 cites W2946188672 @default.
- W4319659088 cites W2947891482 @default.
- W4319659088 cites W2963568636 @default.