FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319661567> ?p ?o ?g. }

• W4319661567 abstract "Abstract Parkinson’s disease (PD) is a neurodegenerative disorder commonly accompanied by motor dysfunction. Electroacupuncture (EA) has shown anti-inflammatory and neuroprotective effects, although the potential mechanisms remain unclear. We speculated that EA could ameliorate the motor dysfunction of PD and that this would be associated with its regulatory impact on the intestinal microbiota. We applied 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to establish a PD mouse model. EA at the GV16, LR3, and ST36 acupoints was administrated for 12 consecutive days. The results of the open-field test indicated that EA alleviated depression and behavioral defects in PD mice. Further study showed that EA upregulated the expressions of tyrosine hydroxylase (TH) and brain-derived neurotrophic factor (BDNF), and blocked the accumulation of α-synuclein (α-syn) in the midbrain. Additionally, EA increased the mRNA levels of neurotrophic factors like BDNF and GDNF. Moreover, EA prevented the damage to intestinal tissues of PD mice, indicative of suppressed NLRP3 inflammasome activation and increased gut barrier integrity. Notably, the antibiotic-treated mouse experiment validated that the gut microbiota was critical in alleviating PD dyskinesia and intestinal inflammation by EA. In conclusion, our study demonstrated that EA intervention could improve PD by alleviating behavioral defects and gut barrier damage, which provides novel insights into the pathogenesis of PD and its therapy." @default.
• W4319661567 created "2023-02-10" @default.
• W4319661567 creator A5012271745 @default.
• W4319661567 creator A5033185934 @default.
• W4319661567 creator A5035495739 @default.
• W4319661567 creator A5067057402 @default.
• W4319661567 creator A5079518307 @default.
• W4319661567 creator A5080241467 @default.
• W4319661567 creator A5083102596 @default.
• W4319661567 date "2023-02-09" @default.
• W4319661567 modified "2023-10-18" @default.
• W4319661567 title "Electroacupuncture alleviates motor dysfunction and gut barrier damage by modulating intestinal NLRP3 inflammasome in MPTP-induced Parkinson's disease mice" @default.
• W4319661567 cites W1979237351 @default.
• W4319661567 cites W1981005146 @default.
• W4319661567 cites W2051525006 @default.
• W4319661567 cites W2057696047 @default.
• W4319661567 cites W2075745941 @default.
• W4319661567 cites W2106350754 @default.
• W4319661567 cites W2130457479 @default.
• W4319661567 cites W2152751399 @default.
• W4319661567 cites W2174227504 @default.
• W4319661567 cites W2225074001 @default.
• W4319661567 cites W2275617881 @default.
• W4319661567 cites W2328119063 @default.
• W4319661567 cites W2473231065 @default.
• W4319661567 cites W2558041282 @default.
• W4319661567 cites W2575605891 @default.
• W4319661567 cites W2582624056 @default.
• W4319661567 cites W2745732476 @default.
• W4319661567 cites W2769487763 @default.
• W4319661567 cites W2790100459 @default.
• W4319661567 cites W2804970493 @default.
• W4319661567 cites W2806361927 @default.
• W4319661567 cites W2888863770 @default.
• W4319661567 cites W2905177566 @default.
• W4319661567 cites W2950056411 @default.
• W4319661567 cites W2950809148 @default.
• W4319661567 cites W3008485740 @default.
• W4319661567 cites W3013580565 @default.
• W4319661567 cites W3043243591 @default.
• W4319661567 cites W3093661831 @default.
• W4319661567 cites W3093878129 @default.
• W4319661567 cites W3111504247 @default.
• W4319661567 cites W3127503198 @default.
• W4319661567 cites W3133822785 @default.
• W4319661567 cites W3153668192 @default.
• W4319661567 cites W3188306957 @default.
• W4319661567 cites W3196192820 @default.
• W4319661567 cites W3198153781 @default.
• W4319661567 cites W3205697444 @default.
• W4319661567 cites W3216805703 @default.
• W4319661567 cites W4206481149 @default.
• W4319661567 cites W934758482 @default.
• W4319661567 doi "https://doi.org/10.21203/rs.3.rs-2530018/v1" @default.
• W4319661567 hasPublicationYear "2023" @default.
• W4319661567 type Work @default.
• W4319661567 citedByCount "0" @default.
• W4319661567 crossrefType "posted-content" @default.
• W4319661567 hasAuthorship W4319661567A5012271745 @default.
• W4319661567 hasAuthorship W4319661567A5033185934 @default.
• W4319661567 hasAuthorship W4319661567A5035495739 @default.
• W4319661567 hasAuthorship W4319661567A5067057402 @default.
• W4319661567 hasAuthorship W4319661567A5079518307 @default.
• W4319661567 hasAuthorship W4319661567A5080241467 @default.
• W4319661567 hasAuthorship W4319661567A5083102596 @default.
• W4319661567 hasBestOaLocation W43196615671 @default.
• W4319661567 hasConcept C126322002 @default.
• W4319661567 hasConcept C134018914 @default.
• W4319661567 hasConcept C142724271 @default.
• W4319661567 hasConcept C159167319 @default.
• W4319661567 hasConcept C160539049 @default.
• W4319661567 hasConcept C170493617 @default.
• W4319661567 hasConcept C177857423 @default.
• W4319661567 hasConcept C185856081 @default.
• W4319661567 hasConcept C203014093 @default.
• W4319661567 hasConcept C204787440 @default.
• W4319661567 hasConcept C25498285 @default.
• W4319661567 hasConcept C2776202274 @default.
• W4319661567 hasConcept C2776914184 @default.
• W4319661567 hasConcept C2777209026 @default.
• W4319661567 hasConcept C2778674702 @default.
• W4319661567 hasConcept C2778790584 @default.
• W4319661567 hasConcept C2779085643 @default.
• W4319661567 hasConcept C2779134260 @default.
• W4319661567 hasConcept C2779734285 @default.
• W4319661567 hasConcept C2780942790 @default.
• W4319661567 hasConcept C513476851 @default.
• W4319661567 hasConcept C539455810 @default.
• W4319661567 hasConcept C56837625 @default.
• W4319661567 hasConcept C71924100 @default.
• W4319661567 hasConcept C98274493 @default.
• W4319661567 hasConceptScore W4319661567C126322002 @default.
• W4319661567 hasConceptScore W4319661567C134018914 @default.
• W4319661567 hasConceptScore W4319661567C142724271 @default.
• W4319661567 hasConceptScore W4319661567C159167319 @default.
• W4319661567 hasConceptScore W4319661567C160539049 @default.
• W4319661567 hasConceptScore W4319661567C170493617 @default.
• W4319661567 hasConceptScore W4319661567C177857423 @default.
• W4319661567 hasConceptScore W4319661567C185856081 @default.
• W4319661567 hasConceptScore W4319661567C203014093 @default.

• next