Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319662242> ?p ?o ?g. }
- W4319662242 endingPage "123606" @default.
- W4319662242 startingPage "123606" @default.
- W4319662242 abstract "In this work we will discuss the antiproliferative evaluation and the possible mechanisms of action of indole-thiosemicarbazone compounds LTs with anti-inflammatory activity, previously described in the literature. In this perspective, some analyzes were carried out, such as the study of binding to human serum albumin (HSA) and to biological targets: DNA and human topoisomerase IIα (topo). Antiproliferative study was performed with DU-145, Jukart, MCF-7 and T-47D tumor lines and J774A.1, besides HepG2 macrophages and hemolytic activity. In the HSA interaction tests, the highest binding constant was 3.70 × 106 M-1, referring to LT89 and in the fluorescence, most compounds, except for LT76 and LT87, promoted fluorescent suppression with the largest Stern-Volmer constant for the LT88 3.55 × 104. In the antiproliferative assay with DU-145 and Jurkat strains, compounds LT76 (0.98 ± 0.10/1.23 ± 0.32 μM), LT77 (0.94 ± 0.05/1.18 ± 0.08 μM) and LT87 (0.94 ± 0.12/0.84 ± 0.09 μM) stood out, due to their IC50 values mentioned above. With the MCF-7 and T-47D cell lines, the lowest IC50 was presented by LT81 with values of 0.74 ± 0.12 μM and 0.68 ± 0.10 μM, respectively, followed by the compounds LT76 and LT87. As well as the positive control amsacrine, the compounds LT76, LT81 and LT87 were able to inhibit the enzymatic action of human Topoisomerase IIα." @default.
- W4319662242 created "2023-02-10" @default.
- W4319662242 creator A5000664783 @default.
- W4319662242 creator A5003939036 @default.
- W4319662242 creator A5016832592 @default.
- W4319662242 creator A5019225382 @default.
- W4319662242 creator A5034276018 @default.
- W4319662242 creator A5055966074 @default.
- W4319662242 creator A5058281576 @default.
- W4319662242 creator A5066444259 @default.
- W4319662242 creator A5068204160 @default.
- W4319662242 creator A5071408494 @default.
- W4319662242 creator A5077542541 @default.
- W4319662242 creator A5079556443 @default.
- W4319662242 creator A5087822310 @default.
- W4319662242 date "2023-04-01" @default.
- W4319662242 modified "2023-10-16" @default.
- W4319662242 title "Interaction study with DNA/HSA, anti-topoisomerase IIα, cytotoxicity and in vitro antiproliferative evaluations and molecular docking of indole-thiosemicarbazone compounds" @default.
- W4319662242 cites W1598392272 @default.
- W4319662242 cites W1975192341 @default.
- W4319662242 cites W1984811585 @default.
- W4319662242 cites W1988636074 @default.
- W4319662242 cites W2004859816 @default.
- W4319662242 cites W2008324827 @default.
- W4319662242 cites W2009867031 @default.
- W4319662242 cites W2017100580 @default.
- W4319662242 cites W2017137665 @default.
- W4319662242 cites W2024310820 @default.
- W4319662242 cites W2036159218 @default.
- W4319662242 cites W2044851985 @default.
- W4319662242 cites W2051644638 @default.
- W4319662242 cites W2058293146 @default.
- W4319662242 cites W2063038129 @default.
- W4319662242 cites W2072272688 @default.
- W4319662242 cites W2075387097 @default.
- W4319662242 cites W2093084777 @default.
- W4319662242 cites W2094156804 @default.
- W4319662242 cites W2100592123 @default.
- W4319662242 cites W2101962857 @default.
- W4319662242 cites W2105668062 @default.
- W4319662242 cites W2117692326 @default.
- W4319662242 cites W2141603634 @default.
- W4319662242 cites W2142522826 @default.
- W4319662242 cites W2165200432 @default.
- W4319662242 cites W2254474217 @default.
- W4319662242 cites W2320529499 @default.
- W4319662242 cites W2414844657 @default.
- W4319662242 cites W2504508783 @default.
- W4319662242 cites W2593436234 @default.
- W4319662242 cites W2604402103 @default.
- W4319662242 cites W2611661726 @default.
- W4319662242 cites W2613728768 @default.
- W4319662242 cites W2805389689 @default.
- W4319662242 cites W2810664437 @default.
- W4319662242 cites W2911707917 @default.
- W4319662242 cites W2944455666 @default.
- W4319662242 cites W2946151277 @default.
- W4319662242 cites W2949269479 @default.
- W4319662242 cites W2961030705 @default.
- W4319662242 cites W2965478636 @default.
- W4319662242 cites W2970819265 @default.
- W4319662242 cites W2980164919 @default.
- W4319662242 cites W2986391790 @default.
- W4319662242 cites W2988773550 @default.
- W4319662242 cites W3008729631 @default.
- W4319662242 cites W3041426930 @default.
- W4319662242 cites W3085027205 @default.
- W4319662242 cites W3086022627 @default.
- W4319662242 cites W3094295250 @default.
- W4319662242 cites W3113535539 @default.
- W4319662242 cites W3117408774 @default.
- W4319662242 cites W3131594033 @default.
- W4319662242 cites W3153142623 @default.
- W4319662242 cites W3163597205 @default.
- W4319662242 cites W3183151101 @default.
- W4319662242 cites W3183633035 @default.
- W4319662242 cites W3196478142 @default.
- W4319662242 cites W3199577367 @default.
- W4319662242 cites W3204987862 @default.
- W4319662242 cites W3213777820 @default.
- W4319662242 cites W3215686817 @default.
- W4319662242 cites W4200368518 @default.
- W4319662242 cites W4206533354 @default.
- W4319662242 cites W4220674899 @default.
- W4319662242 cites W4224941059 @default.
- W4319662242 cites W4225529913 @default.
- W4319662242 cites W4226442636 @default.
- W4319662242 cites W4247088117 @default.
- W4319662242 cites W4280629397 @default.
- W4319662242 cites W4296425583 @default.
- W4319662242 cites W869793459 @default.
- W4319662242 doi "https://doi.org/10.1016/j.ijbiomac.2023.123606" @default.
- W4319662242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36773880" @default.
- W4319662242 hasPublicationYear "2023" @default.
- W4319662242 type Work @default.
- W4319662242 citedByCount "0" @default.
- W4319662242 crossrefType "journal-article" @default.
- W4319662242 hasAuthorship W4319662242A5000664783 @default.