FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319663010> ?p ?o ?g. }

• W4319663010 endingPage "22.2023" @default.
• W4319663010 startingPage "ENEURO.0340" @default.
• W4319663010 abstract "Abstract Hyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway is linked to more than a dozen neurologic diseases, causing a range of pathologies, including excess neuronal growth, disrupted neuronal migration, cortical dysplasia, epilepsy and autism. The mTOR pathway also regulates angiogenesis. For the present study, therefore, we queried whether loss of Pten or Tsc2 , both mTOR negative regulators, alters brain vasculature in three mouse models: one with Pten loss restricted to hippocampal dentate granule cells [DGC- Pten knock-outs (KOs)], a second with widespread Pten loss from excitatory forebrain neurons (FB- Pten KOs) and a third with focal loss of Tsc2 from cortical excitatory neurons (f- Tsc2 KOs). Total hippocampal vessel length and volume per dentate gyrus were dramatically increased in DGC- Pten knock-outs. DGC- Pten knock-outs had larger dentate gyri overall, however, and when normalized to these larger structures, vessel density was preserved. In addition, tests of blood-brain barrier integrity did not reveal increased permeability. FB- Pten KOs recapitulated the findings in the more restricted DGC- Pten KOs, with increased vessel area, but preserved vessel density. FB- Pten KOs did, however, exhibit elevated levels of the angiogenic factor VegfA. In contrast to findings with Pten , focal loss of Tsc2 from cortical excitatory neurons produced a localized increase in vessel density. Together, these studies demonstrate that hypervascularization is not a consistent feature of mTOR hyperactivation models and suggest that loss of different mTOR pathway regulatory genes exert distinct effects on angiogenesis." @default.
• W4319663010 created "2023-02-10" @default.
• W4319663010 creator A5017042606 @default.
• W4319663010 creator A5048531890 @default.
• W4319663010 creator A5049122946 @default.
• W4319663010 creator A5059697093 @default.
• W4319663010 creator A5077984768 @default.
• W4319663010 creator A5080334771 @default.
• W4319663010 date "2023-02-01" @default.
• W4319663010 modified "2023-10-16" @default.
• W4319663010 title "Neurovascular Development in<i>Pten</i>and<i>Tsc2</i>Mouse Mutants" @default.
• W4319663010 cites W1501060173 @default.
• W4319663010 cites W1832832250 @default.
• W4319663010 cites W1971291493 @default.
• W4319663010 cites W1976748435 @default.
• W4319663010 cites W1985950007 @default.
• W4319663010 cites W1986442348 @default.
• W4319663010 cites W1997531724 @default.
• W4319663010 cites W2012083949 @default.
• W4319663010 cites W2014087704 @default.
• W4319663010 cites W2023134133 @default.
• W4319663010 cites W2033027320 @default.
• W4319663010 cites W2036811411 @default.
• W4319663010 cites W2040675974 @default.
• W4319663010 cites W2049069390 @default.
• W4319663010 cites W2051096912 @default.
• W4319663010 cites W2058386552 @default.
• W4319663010 cites W2062997257 @default.
• W4319663010 cites W2067874044 @default.
• W4319663010 cites W2098216863 @default.
• W4319663010 cites W2102024140 @default.
• W4319663010 cites W2109854832 @default.
• W4319663010 cites W2117544077 @default.
• W4319663010 cites W2132482143 @default.
• W4319663010 cites W2133659563 @default.
• W4319663010 cites W2137384928 @default.
• W4319663010 cites W2143654068 @default.
• W4319663010 cites W2202300859 @default.
• W4319663010 cites W2221760487 @default.
• W4319663010 cites W2297117323 @default.
• W4319663010 cites W2347029403 @default.
• W4319663010 cites W2438878101 @default.
• W4319663010 cites W2516739123 @default.
• W4319663010 cites W2553119477 @default.
• W4319663010 cites W2593110709 @default.
• W4319663010 cites W2626329567 @default.
• W4319663010 cites W2740567517 @default.
• W4319663010 cites W2753003866 @default.
• W4319663010 cites W2767699453 @default.
• W4319663010 cites W2793783592 @default.
• W4319663010 cites W2802067943 @default.
• W4319663010 cites W2809715497 @default.
• W4319663010 cites W2883345188 @default.
• W4319663010 cites W2892748605 @default.
• W4319663010 cites W2938330154 @default.
• W4319663010 cites W2944147603 @default.
• W4319663010 cites W2944922556 @default.
• W4319663010 cites W2945799337 @default.
• W4319663010 cites W2951509735 @default.
• W4319663010 cites W2966359129 @default.
• W4319663010 cites W2978572671 @default.
• W4319663010 cites W2980725598 @default.
• W4319663010 cites W2992458349 @default.
• W4319663010 cites W2997317037 @default.
• W4319663010 cites W3001854505 @default.
• W4319663010 cites W3007248878 @default.
• W4319663010 cites W3016837853 @default.
• W4319663010 cites W3045348625 @default.
• W4319663010 cites W3048771804 @default.
• W4319663010 cites W3092931556 @default.
• W4319663010 cites W3112056080 @default.
• W4319663010 cites W3137713058 @default.
• W4319663010 cites W3156227077 @default.
• W4319663010 cites W3190768045 @default.
• W4319663010 cites W4283751491 @default.
• W4319663010 cites W4296816736 @default.
• W4319663010 doi "https://doi.org/10.1523/eneuro.0340-22.2023" @default.
• W4319663010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36759189" @default.
• W4319663010 hasPublicationYear "2023" @default.
• W4319663010 type Work @default.
• W4319663010 citedByCount "1" @default.
• W4319663010 countsByYear W43196630102023 @default.
• W4319663010 crossrefType "journal-article" @default.
• W4319663010 hasAuthorship W4319663010A5017042606 @default.
• W4319663010 hasAuthorship W4319663010A5048531890 @default.
• W4319663010 hasAuthorship W4319663010A5049122946 @default.
• W4319663010 hasAuthorship W4319663010A5059697093 @default.
• W4319663010 hasAuthorship W4319663010A5077984768 @default.
• W4319663010 hasAuthorship W4319663010A5080334771 @default.
• W4319663010 hasBestOaLocation W43196630101 @default.
• W4319663010 hasConcept C148762608 @default.
• W4319663010 hasConcept C169760540 @default.
• W4319663010 hasConcept C2776464000 @default.
• W4319663010 hasConcept C2777609662 @default.
• W4319663010 hasConcept C2779422105 @default.
• W4319663010 hasConcept C2780394083 @default.
• W4319663010 hasConcept C502942594 @default.
• W4319663010 hasConcept C62478195 @default.

• next