Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319705200> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4319705200 endingPage "355" @default.
- W4319705200 startingPage "347" @default.
- W4319705200 abstract "High concentrations (105 μequiv./ml) of potassium ions in the incubation medium bring about reduced uptakes of L-glutamate, L-aspartate, and glycine but not of L-glutamine into rat brain cortex slices incubated aerobically in a physiological saline – glucose medium. The reductions are suppressed by acetylcholine (20 μM – 2 mM) in presence of eserine (0.1 mM) and not by tetrodotoxin (3 μM). The effect of acetylcholine is calcium dependent. It is diminished by atropine but not by d-tubocurarine (1 mM). Protoveratrine (5 μM) inhibition of amino acid uptake is not affected by acetylcholine but it is suppressed by tetrodotoxin. Acetylcholine and tetrodotoxin act independently of each other. Acetylcholine suppresses the potassium-evoked release of endogenous glutamate, aspartate, or glycine from incubated rat brain cortex slices. Its action on release is calcium dependent. Acetylcholine also suppresses the potassium-induced release of amino acids from rat brain cortex slices that have been previously incubated with 2 mM sodium L-glutamate or 2 mM sodium L-aspartate.It is suggested that increased cell concentrations of calcium ions, owing to high concentrations of potassium ions in the incubation medium, cause an increased glial permeability to sodium ions, with a resultant diminution of the sodium gradient. This diminution is considered to be responsible for the diminished concentrative uptake of L-glutamate, L-aspartate, or glycine, and the increased release of these amino acids. Acetylcholine suppresses the permeability change due to high concentrations of potassium ions and reverses the changed sodium gradient and the consequent change in amino acid uptake and release. It would seem that accumulation of acetylcholine in the intracellular spaces may affect glia, as well as neurons, modifying permeability to sodium ions and to various amino acids now assuming importance as possible transmitters." @default.
- W4319705200 created "2023-02-10" @default.
- W4319705200 creator A5025447175 @default.
- W4319705200 creator A5027200654 @default.
- W4319705200 date "1977-06-01" @default.
- W4319705200 modified "2023-10-18" @default.
- W4319705200 title "Effects of acetylcholine on potassium-induced changes of some amino acid uptakes and release in cerebral cortex slices from the rat" @default.
- W4319705200 doi "https://doi.org/10.1139/y77-049" @default.
- W4319705200 hasPublicationYear "1977" @default.
- W4319705200 type Work @default.
- W4319705200 citedByCount "10" @default.
- W4319705200 crossrefType "journal-article" @default.
- W4319705200 hasAuthorship W4319705200A5025447175 @default.
- W4319705200 hasAuthorship W4319705200A5027200654 @default.
- W4319705200 hasConcept C126322002 @default.
- W4319705200 hasConcept C134018914 @default.
- W4319705200 hasConcept C170493617 @default.
- W4319705200 hasConcept C178790620 @default.
- W4319705200 hasConcept C185592680 @default.
- W4319705200 hasConcept C2775859210 @default.
- W4319705200 hasConcept C2775910092 @default.
- W4319705200 hasConcept C2776741303 @default.
- W4319705200 hasConcept C2777756961 @default.
- W4319705200 hasConcept C2779349466 @default.
- W4319705200 hasConcept C2781041448 @default.
- W4319705200 hasConcept C515207424 @default.
- W4319705200 hasConcept C517785266 @default.
- W4319705200 hasConcept C519063684 @default.
- W4319705200 hasConcept C537181965 @default.
- W4319705200 hasConcept C55493867 @default.
- W4319705200 hasConcept C61174792 @default.
- W4319705200 hasConcept C71924100 @default.
- W4319705200 hasConcept C86803240 @default.
- W4319705200 hasConceptScore W4319705200C126322002 @default.
- W4319705200 hasConceptScore W4319705200C134018914 @default.
- W4319705200 hasConceptScore W4319705200C170493617 @default.
- W4319705200 hasConceptScore W4319705200C178790620 @default.
- W4319705200 hasConceptScore W4319705200C185592680 @default.
- W4319705200 hasConceptScore W4319705200C2775859210 @default.
- W4319705200 hasConceptScore W4319705200C2775910092 @default.
- W4319705200 hasConceptScore W4319705200C2776741303 @default.
- W4319705200 hasConceptScore W4319705200C2777756961 @default.
- W4319705200 hasConceptScore W4319705200C2779349466 @default.
- W4319705200 hasConceptScore W4319705200C2781041448 @default.
- W4319705200 hasConceptScore W4319705200C515207424 @default.
- W4319705200 hasConceptScore W4319705200C517785266 @default.
- W4319705200 hasConceptScore W4319705200C519063684 @default.
- W4319705200 hasConceptScore W4319705200C537181965 @default.
- W4319705200 hasConceptScore W4319705200C55493867 @default.
- W4319705200 hasConceptScore W4319705200C61174792 @default.
- W4319705200 hasConceptScore W4319705200C71924100 @default.
- W4319705200 hasConceptScore W4319705200C86803240 @default.
- W4319705200 hasIssue "3" @default.
- W4319705200 hasLocation W43197052001 @default.
- W4319705200 hasOpenAccess W4319705200 @default.
- W4319705200 hasPrimaryLocation W43197052001 @default.
- W4319705200 hasRelatedWork W1563860881 @default.
- W4319705200 hasRelatedWork W1576478358 @default.
- W4319705200 hasRelatedWork W2049748437 @default.
- W4319705200 hasRelatedWork W2052762080 @default.
- W4319705200 hasRelatedWork W2056793944 @default.
- W4319705200 hasRelatedWork W2061769920 @default.
- W4319705200 hasRelatedWork W2068660968 @default.
- W4319705200 hasRelatedWork W2093198910 @default.
- W4319705200 hasRelatedWork W2345051906 @default.
- W4319705200 hasRelatedWork W3196326223 @default.
- W4319705200 hasVolume "55" @default.
- W4319705200 isParatext "false" @default.
- W4319705200 isRetracted "false" @default.
- W4319705200 workType "article" @default.